Methylation-Mediated Transcriptional Silencing in Euchromatin by Methyl-CpG Binding Protein MBD1 Isoforms

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

1996 • 5,667 citations

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1998 • 3,363 citations

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

1998 • 2,686 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 • 1,960 citations

Role for DNA methylation in genomic imprinting

1994 • 1,695 citations

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

1994 • 1,542 citations

Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif

1988 • 1,403 citations

Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA

1992 • 1,331 citations

Identification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins

1998 • 1,317 citations

MeCP2 Is a Transcriptional Repressor with Abundant Binding Sites in Genomic Chromatin

1997 • 1,258 citations

Number of CpG islands and genes in human and mouse.

1993 • 986 citations

Structure and Function in the Nucleus

1998 • 925 citations

E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas.

1995 • 803 citations

DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein

1991 • 722 citations

Autoantibody to centromere (kinetochore) in scleroderma sera.

1980 • 721 citations

Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs

1989 • 655 citations

GENOMIC IMPRINTING IN MAMMALS

1997 • 641 citations

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1996 • 614 citations

Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2

1993 • 584 citations

CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation.

1989 • 554 citations

How does DNA methylation repress transcription?

1997 • 532 citations

Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression.

1994 • 493 citations

Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl-CpG binding protein.

1992 • 472 citations

Gene number, noise reduction and biological complexity

1995 • 462 citations

Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain.

1992 • 454 citations

Deletions of a differentially methylated CpG island at the SNRPN gene define a putative imprinting control region

1994 • 430 citations

Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated.

1988 • 308 citations

An embryonic-like methylation pattern of classical satellite DNA is observed in ICF syndrome

1993 • 281 citations

The Human Polycomb Group Complex Associates with Pericentromeric Heterochromatin to Form a Novel Nuclear Domain

1998 • 279 citations

In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cells.

1982 • 271 citations

5-Methylcytosine localised in mammalian constitutive heterochromatin

1974 • 267 citations

A component of the transcriptional represser MeCP1 shares a motif with DNA methyltransferase and HRX proteins

1997 • 242 citations

Chromatin structure is required to block transcription of the methylated herpes simplex virus thymidine kinase gene.

1987 • 241 citations

DNA methyltransferases

1994 • 237 citations

Characterization of drosophila transcription factors that activate the tandem promoters of the alcohol dehydrogenase gene

1985 • 229 citations

The absence of detectable methylated bases in Drosophila melanogaster DNA

1982 • 211 citations

Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond.

1997 • 163 citations

Methyl-CpG-Binding Protein MeCP2 Represses Sp1-Activated Transcription of the Human Leukosialin Gene When the Promoter Is Methylated

1998 • 152 citations

Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond

1997 • 140 citations

Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases.

1993 • 139 citations

Chicken MAR-Binding Protein ARBP Is Homologous to Rat Methyl-CpG-Binding Protein MeCP2

1997 • 108 citations

The repressor MDBP-2 is a member of the histone H1 family that binds preferentially in vitro and in vivo to methylated nonspecific DNA sequences.

1992 • 79 citations

Mammalian X-chromosome inactivation and the XIST gene

1992 • 75 citations

Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein

1997 • 59 citations

Minireview

1998 • 58 citations

Genomic Imprinting, DNA Methylation, and Cancer

1994 • 53 citations

In vitrotranscription with extracts of nuclei ofDrosophilaembryos

1985 • 50 citations

Genomic Imprinting, DNA Methylation, and Cancer

1994 • 48 citations

Links between chromatin structure, DNA repair and chromosome fragility

1998 • 36 citations

In vivo estradiol-dependent dephosphorylation of the repressor MDBP-2-H1 correlates with the loss of in vitro preferential binding to methylated DNA.

1995 • 15 citations

Phosphorylation/dephosphorylation of the repressor MDBP-2-H1 selectively affects the level of transcription from a methylated promoter in vitro

1996 • 12 citations