DNA methyltransferases

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

1992 • 1,027 citations

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

1992 • 944 citations

Hhal methyltransferase flips its target base out of the DNA helix

1994 • 936 citations

Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells

1988 • 891 citations

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

1992 • 850 citations

Arabidopsis thaliana DNA Methylation Mutants

1993 • 674 citations

Macromolecular Domains within the Cell Nucleus

1993 • 611 citations

Predictive motifs derived from cytosine methyltransferases

1989 • 505 citations

Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain.

1992 • 454 citations

Kinetic and catalytic mechanism of HhaI methyltransferase.

1987 • 416 citations

Nopp 140 shuttles on tracks between nucleolus and cytoplasm

1992 • 409 citations

On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs

1983 • 404 citations

A single mode of DNA base-pair opening drives imino proton exchange

1987 • 380 citations

Mapping polycomb-repressed domains in the bithorax complex using in vivo formaldehyde cross-linked chromatin

1993 • 360 citations

Crystal structure of the Hhal DNA methyltransferase complexed with S-adenosyl-l-methionine

1993 • 357 citations

Isolation and identification by sequence homology of a putative cytosine methyltransferase fromArabidopsis thaliana

1993 • 253 citations

Direct identification of the active-site nucleophile in a DNA (cytosine-5)-methyltransferase

1991 • 246 citations

Cytosine-specific type II DNA methyltransferases

1989 • 230 citations

DNA methylation: evolution of a bacterial immune function into a regulator of gene expression and genome structure in higher eukaryotes

1990 • 227 citations

Arginine/serine-rich domains of the su(wa) and tra RNA processing regulators target proteins to a subnuclear compartment implicated in splicing

1991 • 224 citations

Characterization of base-pair opening in deoxynucleotide duplexes using catalyzed exchange of the imino proton

1988 • 210 citations

Parental imprinting of autosomal mammalian genes

1994 • 208 citations

Understanding enzyme-catalyzed proton abstraction from carbon acids: details of stepwise mechanisms for .beta.-elimination reactions

1992 • 177 citations

Mechanism of human methyl-directed DNA methyltransferase and the fidelity of cytosine methylation.

1992 • 143 citations

Sequential order of target-recognizing domains in multispecific DNA-methyltransferases.

1988 • 116 citations

Mechanisms of heritable gene repression during development of Drosophila

1993 • 113 citations

The sequence specificity domain of cytosine-C5 methylases

1991 • 108 citations

5-Fluorocytosine in DNA is a mechanism-based inhibitor of HhaI methylase

1988 • 106 citations

Recognition of unusual DNA structures by human DNA(cytosine-5)methyltransferase

1991 • 100 citations

Transcriptional repression by methylation of CpG

1992 • 93 citations

DNA methylation through a locally unpaired intermediate

1993 • 83 citations

Cytosine methylation The pros and cons of DNA methylation

1993 • 83 citations

The cysteine conserved among DNA cytosine methylasesis required for methyl transfer, but not for specific DNA binding

1993 • 76 citations

Chimeric multispecific DNA methyltransferases with novel combinations of target recognition

1988 • 72 citations

The flip side of DNA methylation

1994 • 62 citations

Sequence-specific DNA binding by theMspl DNA methyltransferase

1992 • 56 citations

The irreversible binding of azacytosine-containing DNA fragments to bacterial DNA(cytosine-5)methyltransferases.

1985 • 56 citations

Mutational separation of DNA binding from catalysis in a DNA cytosine methyltransferase

1993 • 55 citations

The DNA binding affinity ofHhalmethylase is increased by a single amino acid substitution in the catalytic center

1993 • 55 citations

Sequence-specific and mechanism-based crosslinking of Dcm DNA cytosine-C⁵methyltransferase ofE.coliK-12 to synthetic oligonucleotides containing 5-fluoro-2'-deoxycytidine

1993 • 42 citations

Binding of the EcoRII methyltransferase to 5-fluorocytosine-containing DNA. Isolation of a bound peptide

1992 • 41 citations

Chemical synthesis of 2′-deoxyoligonucleotides containing 5-fluoro-2′-deoxycytidine

1992 • 25 citations

Synthesis of an oligonucleotide suicide substrate for DNA methyltransferases

1992 • 22 citations

Crystallization and Preliminary Crystallographic Analysis of a DNA (Cytosine-5)-Methyltransferase from Haemophilus aegyptius Bound Covalently to DNA

1994 • 7 citations