Phosphorylation of p105 PEST Sequences via a Redox-insensitive Pathway Up-regulates Processing to p50 NF-κB

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1987 • 11,491 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

Activation in vitro of NF-κB" by phosphorylation of its inhibitor IκB"

1990 • 1,202 citations

NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway

1993 • 1,141 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity

1991 • 746 citations

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.

1994 • 723 citations

Coupling of a Signal Response Domain in IκBα to Multiple Pathways for NF-κB Activation

1995 • 706 citations

Autoregulation of I kappa B alpha activity.

1994 • 419 citations

NF-κB and related proteins: Rel/dorsal homologies meet ankyrin-like repeats

1992 • 415 citations

The precursor of NF-κB p50 has IκB-like functions

1992 • 409 citations

Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway.

1994 • 389 citations

Activation of NF-kappa B in vivo is regulated by multiple phosphorylations.

1994 • 362 citations

Phosphorylation of IκBα Precedes but Is Not Sufficient for Its Dissociation from NF-κB

1995 • 351 citations

Cytokine-inducible expression in endothelial cells of an I kappa B alpha-like gene is regulated by NF kappa B.

1993 • 338 citations

Promoter analysis of the gene encoding the I kappa B-alpha/MAD3 inhibitor of NF-kappa B: positive regulation by members of the rel/NF-kappa B family.

1993 • 331 citations

Generation of p50 subunit of NF-kB by processing of p105 through an ATP-dependent pathway

1991 • 316 citations

Inducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitors.

1994 • 302 citations

p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction.

1993 • 291 citations

IκBγ, a 70 kd protein identical to the C-terminal half of p110 NF-κB: A new member of the IκB family

1992 • 274 citations

The characterization of the promoter of the gene encoding the p50 subunit of NF-kappa B indicates that it participates in its own regulation.

1992 • 258 citations

Rel-Associated pp40: an Inhibitor of the Rel Family of Transcription Factors

1991 • 255 citations

Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa B.

1995 • 243 citations

Redox status of cells influences constitutive or induced NF-kappa B translocation and HIV long terminal repeat activity in human T and monocytic cell lines.

1992 • 242 citations

N- and C-Terminal Sequences Control Degradation of MAD3/IκBα in Response to Inducers of NF-κB Activity

1995 • 227 citations

Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B.

1994 • 209 citations

RelA/p65 is a molecular target for the immunosuppressive action of protein kinase A.

1995 • 198 citations

Proteolytic degradation of MAD3 (IϰBα) and enhanced processing of the NF-ϰB precursor p105 are obligatory steps in the activation of NF-ϰB

1993 • 194 citations

Autoregulation of the NF-kappa B transactivator RelA(p65) by multiple cytoplasmic inhibitors containing ankyrinmotifs.

1994 • 187 citations

The inhibitory ankyrin and activator Rel proteins

1992 • 185 citations

Cytoplasmic retention, DNA binding and processing of the NF-kappa B p50 precursor are controlled by a small region in its C-terminus.

1991 • 182 citations

In Vivo Stimulation of IκB Phosphorylation Is Not Sufficient To Activate NF-κB

1995 • 164 citations

Constitutive phosphorylation of I kappa B alpha by casein kinase II.

1995 • 160 citations

Signal transduction for nuclear factor-kappa B activation. Proposed location of antioxidant-inhibitable step.

1994 • 158 citations

Phosphorylation of transcriptional factors and cell-cycle-dependent proteins by casein kinase II

1991 • 116 citations

Promoter of the human NF-kappa B p50/p105 gene. Regulation by NF-kappa B subunits and by c-REL.

1993 • 104 citations

Inducible Degradation of IκBα In Vitro and In Vivo Requires the Acidic C-Terminal Domain of the Protein

1995 • 103 citations

Regulated expression of an immunoglobulin kappa gene introduced into a mouse lymphoid cell line.

1982 • 100 citations

Activation of NF-κB by Phosphatase Inhibitors Involves the Phosphorylation of IκBα at Phosphatase 2A-sensitive Sites

1995 • 96 citations

Proteolytic Processing of NF- κB/I κB in Human Monocytes

1995 • 88 citations

Phosphorylation of NF-KB1-p50 is involved in NF-kappa B activation and stable DNA binding.

1994 • 66 citations

NF-kappa B-dependent induction of the NF-kappa B p50 subunit gene promoter underlies self-perpetuation of human immunodeficiency virus transcription in monocytic cells.

1992 • 60 citations

Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimers

1994 • 58 citations

Identification of complex formation between two intracellular tyrosine kinase substrates: human c-Rel and the p105 precursor of p50 NF-kappa B.

1992 • 47 citations

NF-κB/Rel family members are physically associated phosphoproteins

1994 • 46 citations

Alternative splicing of RNA transcripts encoded by the murine p105 NF-kappa B gene generates I kappa B gamma isoforms with different inhibitory activities.

1994 • 40 citations

The activity of a 70 kilodalton I kappa B molecule identical to the carboxyl terminus of the p105 NF-kappa B precursor is modulated by protein kinase A.

1993 • 30 citations

Alternate RNA splicing of murine nfkb1 generates a nuclear isoform of the p50 precursor NF-kappa B1 that can function as a transactivator of NF-kappa B-regulated transcription.

1994 • 24 citations