Involvement of proteasomes in migration and matrix metalloproteinase-9 production of oral squamous cell carcinoma

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells.

1993 • 704 citations

Proteolytic degradation of extracellular matrix in tumor invasion

1987 • 484 citations

Mechanistic aspects of NF-κB regulation: The emerging role of phosphorylation and proteolysis

1995 • 392 citations

The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression

1995 • 354 citations

Localization of messenger RNA for Mr 72,000 and 92,000 type IV collagenases in human skin cancers by in situ hybridization.

1992 • 331 citations

Antisense inhibition of the p65 subunit of NF-kappa B blocks tumorigenicity and causes tumor regression.

1993 • 268 citations

Growth-inhibitory effects of epidermal growth factor and overexpression of its receptors on human squamous cell carcinomas in culture.

1986 • 252 citations

Ablation of transplanted HTLV-I tax-transformed tumors in mice by antisense inhibition of NF-kappa B

1993 • 249 citations

Ablation of Transplanted HTLV-I Tax-Transformed Tumors in Mice by Antisense Inhibition of NF-κB

1992 • 207 citations

Mr 92,000 gelatinase release correlates with the metastatic phenotype in transformed rat embryo cells.

1990 • 202 citations

Cytokine messenger rna expression in the labial salivary glands of patients with Sjögren's syndrome

1996 • 170 citations

Changes in expressions of proteasome and ubiquitin genes in human renal cancer cells.

1991 • 168 citations

Misregulation of Stromelysin-1 Expression in Mouse Mammary Tumor Cells Accompanies Acquisition of Stromelysin-1-dependent Invasive Properties

1997 • 153 citations

Role and regulation of expression of 92‐kDa type‐IV collagenase (MMP‐9) in 2 invasive squamous‐cell‐carcinoma cell lines of the oral cavity

1993 • 123 citations

The Antitumor Drug Aclacinomycin A, Which Inhibits the Degradation of Ubiquitinated Proteins, Shows Selectivity for the Chymotrypsin-like Activity of the Bovine Pituitary 20 S Proteasome

1996 • 70 citations

Disruption of I kappa B alpha regulation by antisense RNA expression leads to malignant transformation.

1994 • 60 citations

Establishment of high- and low-invasion clones derived for a human tongue squamous-cell carcinoma cell line SAS

1996 • 58 citations

Interleukin 1-induced phosphorylation of MAD3, the major inhibitor of nuclear factor κB of HeLa cells. Interference in signalling by the proteinase inhibitors 2,4-dichloroisocoumarin and tosylphenylalanyl chloromethylketone

1995 • 27 citations

Effects of human fibroblasts on invasiveness of oral cancer cells in vitro: Isolation of a chemotactic factor from human fibroblasts

1996 • 20 citations

Expression of matrix metalloproteinases 1 and 2 genes in a possible association with metastatic abilities of human pancreatic cancer cells

1997 • 5 citations