Neurobiology of Stroke

Tissue Plasminogen Activator for Acute Ischemic Stroke

1995 • 10,997 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Beneficial Effect of Carotid Endarterectomy in Symptomatic Patients with High-Grade Carotid Stenosis

1991 • 8,040 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Reversible middle cerebral artery occlusion without craniectomy in rats.

1989 • 6,875 citations

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1984 • 2,884 citations

Thresholds in cerebral ischemia - the ischemic penumbra.

1981 • 2,780 citations

Temporal profile of neuronal damage in a model of transient forebrain ischemia

1982 • 2,695 citations

The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death

1990 • 2,204 citations

A new model of bilateral hemispheric ischemia in the unanesthetized rat.

1979 • 1,934 citations

Cell Damage in the Brain: A Speculative Synthesis

1981 • 1,827 citations

Small Differences in Intraischemic Brain Temperature Critically Determine the Extent of Ischemic Neuronal Injury

1987 • 1,821 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Fibrinogen as a Risk Factor for Stroke and Myocardial Infarction

1984 • 1,686 citations

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1994 • 1,578 citations

Stroke--1989. Recommendations on stroke prevention, diagnosis, and therapy. Report of the WHO Task Force on Stroke and other Cerebrovascular Disorders.

1989 • 1,433 citations

Focal Cerebral Ischaemia in the Rat: 1. Description of Technique and Early Neuropathological Consequences following Middle Cerebral Artery Occlusion

1981 • 1,420 citations

Regional ischemic 'preconditioning' protects remote virgin myocardium from subsequent sustained coronary occlusion.

1993 • 1,333 citations

Treatment of Traumatic Brain Injury with Moderate Hypothermia

1997 • 1,308 citations

Calcium Fluxes, Calcium Antagonists, and Calcium-Related Pathology in Brain Ischemia, Hypoglycemia, and Spreading Depression: A Unifying Hypothesis

1989 • 1,237 citations

A Randomized Trial Comparing Ticlopidine Hydrochloride with Aspirin for the Prevention of Stroke in High-Risk Patients

1989 • 1,209 citations

The Harvard Cooperative Stroke Registry

1978 • 1,180 citations

Thresholds of focal cerebral ischemia in awake monkeys

1981 • 1,144 citations

Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain.

1989 • 1,110 citations

‘Ischemic tolerance’ phenomenon found in the brain

1990 • 1,098 citations

Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia.

1977 • 1,093 citations

Induction of reproducible brain infarction by photochemically initiated thrombosis

1985 • 1,092 citations

Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb

1996 • 980 citations

The density and distribution of ischemic brain injury in the rat following 2?10 min of forebrain ischemia

1984 • 968 citations

Experimental studies of ischemic brain edema

1986 • 932 citations

THE CANADIAN AMERICAN TICLOPIDINE STUDY (CATS) IN THROMBOEMBOLIC STROKE

1989 • 912 citations

Middle Cerebral Artery Occlusion in the Rat by Intraluminal Suture

1996 • 772 citations

Experimental studies of ischemic brain edema : a new experimental study of ischemic brain edema : 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area

1986 • 770 citations

Stroke: Pathophysiology, Diagnosis, and Management.

1988 • 763 citations

Guidelines for Thrombolytic Therapy for Acute Stroke: A Supplement to the Guidelines for the Management of Patients With Acute Ischemic Stroke

1996 • 721 citations

Enlarged Infarcts in Endothelial Nitric Oxide Synthase Knockout Mice are Attenuated by Nitro-L-Arginine

1996 • 713 citations

Effect of Ischemia on the In Vivo Release of Striatal Dopamine, Glutamate, and γ‐Aminobutyric Acid Studied by Intracerebral Microdialysis

1988 • 704 citations

Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.

1993 • 703 citations

Pharmacology of Cerebral Ischemia

1989 • 675 citations

Rodent models of cerebral ischemia.

1989 • 663 citations

Oxygen radical mechanisms of brain injury following ischemia and reperfusion

1991 • 657 citations

Diaschisis.

1986 • 641 citations

Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke.

1992 • 617 citations

Very Delayed Infarction after Mild Focal Cerebral Ischemia: A Role for Apoptosis?

1996 • 613 citations

Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3.

1991 • 610 citations

Establishment of the strokeprone spontaneously hypertensive rat (SHR)

1972 • 606 citations

Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia

1990 • 589 citations

Induced Tolerance to Ischemia in Gerbil Hippocampal Neurons

1991 • 584 citations

Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia.

1994 • 571 citations

Race, sex and occlusive cerebrovascular disease: a review.

1986 • 551 citations

The glutamate antagonist MK‐801 reduces focal ischemic brain damage in the rat

1988 • 547 citations

A Phase II Study of Moderate Hypothermia in Severe Brain Injury

1993 • 546 citations

Urgent therapy for stroke. Part I. Pilot study of tissue plasminogen activator administered within 90 minutes.

1992 • 541 citations

Nitric oxide and the cerebral circulation.

1994 • 540 citations

Generalized Efficacy of t-PA for Acute Stroke

1997 • 540 citations

The use of moderate therapeutic hypothermia for patients with severe head injuries: a preliminary report

1993 • 534 citations

Free Radicals and Brain Damage

1993 • 527 citations

Apoptosis-the molecular basis of cell death

1992 • 517 citations

A cautionary note on the use of the TUNEL stain to determine apoptosis

1995 • 490 citations

Intraischemic but Not Postischemic Brain Hypothermia Protects Chronically following Global Forebrain Ischemia in Rats

1993 • 481 citations

Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain

1993 • 481 citations

Cigarette Smoking as a Risk Factor for Stroke

1988 • 477 citations

Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period.

1986 • 474 citations

Role of leukocytes in acute myocardial infarction in anesthetized dogs: relationship to myocardial salvage by anti-inflammatory drugs.

1984 • 468 citations

Postischemic moderate hypothermia inhibits CA1 hippocampal ischemic neuronal injury

1989 • 461 citations

Definition and incidence of apoptosis : an historical perspective

1991 • 458 citations

Neuroprotective Effects of Human Recombinant Interleukin-1 Receptor Antagonist in Focal Cerebral Ischaemia in the Rat

1996 • 456 citations

Morphologic, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia.

1992 • 445 citations

Fever in Acute Stroke Worsens Prognosis

1995 • 442 citations

Systolic blood pressure, arterial rigidity, and risk of stroke. The Framingham study

1981 • 431 citations

Cardiogenic brain embolism

1986 • 429 citations

Therapeutic modulation of brain temperature: relevance to ischemic brain injury.

1992 • 429 citations

Apoptosis: The Molecular Basis of Cell Death

1991 • 425 citations

A Controlled Trial of Nimodipine in Acute Ischemic Stroke

1988 • 423 citations

Vascular risks of asymptomatic carotid stenosis.

1991 • 422 citations

Cytokines, inflammation, and brain injury: role of tumor necrosis factor-alpha.

1994 • 421 citations

Delayed and prolonged post-ischemic hypothermia is neuroprotective in the gerbil

1994 • 418 citations

Detection of Free Radical Activity During Transient Global Ischemia and Recirculation: Effects of Intraischemic Brain Temperature Modulation

1995 • 388 citations

Brain injury, edema, and vascular permeability changes induced by oxygen‐derived free radicals

1984 • 387 citations

Cerebrovascular Disease: Pathophysiology, Diagnosis and Management

1998 • 386 citations

Cardiogenic Brain Embolism

1986 • 382 citations

Local intra-arterial fibrinolytic therapy in acute carotid territory stroke. A pilot study.

1988 • 381 citations

Inhibition of mononuclear phagocytes reduces ischemic injury in the spinal cord

1990 • 373 citations

Protective Effect of the Glutamate Antagonist, MK-801 in Focal Cerebral Ischemia in the Cat

1988 • 370 citations

Polyethylene glycol-conjugated superoxide dismutase and catalase reduce ischemic brain injury

1989 • 368 citations

Repeated Negative DC Deflections in Rat Cortex following Middle Cerebral Artery Occlusion are Abolished by MK-801: Effect on Volume of Ischemic Injury

1992 • 361 citations

Anti‐ICAM‐1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in the rat

1994 • 360 citations

Apoptosis and necrosis. Basic types and mechanisms of cell death.

1993 • 353 citations

GLUTAMATE—INDUCED RETINAL DEGENERATION IN NEONATAL MICE. ELECTRON MICROSCOPY OF THE ACUTELY EVOLVING LESION

1969 • 352 citations

Postischemic administration of an anti-Mac-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in rats.

1994 • 347 citations

Guidelines for Thrombolytic Therapy for Acute Stroke: a Supplement to the Guidelines for the Management of Patients with Acute Ischemic Stroke. A statement for healthcare professionals from a Special Writing Group of the Stroke Council, American Heart Association.

1996 • 345 citations

Analysis of Risk Factors for Stroke in a Cohort of Men Born in 1913

1987 • 343 citations

The pilot Stroke Data Bank: definition, design, and data.

1984 • 334 citations

Amelioration of delayed neuronal death in the hippocampus by nerve growth factor

1991 • 333 citations

Systolic Blood Pressure, Arterial Rigidity, and Risk of Stroke

1981 • 332 citations

Effects of normothermic versus mild hyperthermic forebrain ischemia in rats.

1990 • 327 citations

Brain-Derived Neurotrophic Factor Protects against Ischemic Cell Damage in Rat Hippocampus

1994 • 326 citations

Background Review and Current Concepts of Reperfusion Injury

1990 • 323 citations

Prognosis of transient ischemic attacks in the Oxfordshire Community Stroke Project.

1990 • 323 citations

Regional Accumulation of Calcium in Postischemic Rat Brain

1984 • 320 citations

Postischemic Blockade of AMPA but Not NMDA Receptors Mitigates Neuronal Damage in the Rat Brain following Transient Severe Cerebral Ischemia

1992 • 315 citations

Endogenous Neuroprotection Factors and Traumatic Brain Injury: Mechanisms of Action and Implications for Therapy

1994 • 308 citations

Risk of Stroke in Male Cigarette Smokers

1986 • 306 citations

Stroke–Pathophysiology, Diagnosis, and Management

1993 • 304 citations

Temporal profile of the effects of pretreatment with brief cerebral ischemia on the neuronal damage following secondary ischemic insult in the gerbil: cumulative damage and protective effects

1991 • 303 citations

Fibroblast growth factors: activities and significance of non-neurotrophin neurotrophic growth factors

1994 • 298 citations

Epidemiology of Cerebrovascular Disease

1969 • 293 citations

Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation

1997 • 291 citations

Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction

1997 • 291 citations

The Effect of MK-801 on Cortical Spreading Depression in the Penumbral Zone following Focal Ischaemia in the Rat

1992 • 290 citations

Lipid Peroxidation In Vivo Induced by Reversible Global Ischemia in Rat Brain

1984 • 283 citations

MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period

1988 • 276 citations

Moderate alcohol consumption and stroke. The epidemiologic evidence.

1989 • 275 citations

Spreading Depression Induces Tolerance of Cortical Neurons to Ischemia in Rat Brain

1995 • 266 citations

Oxygen Radicals in Focal Cerebral Ischemia

1994 • 263 citations

Stroke: Pathophysiology, Diagnosis, and Management

1986 • 262 citations

Ultrastructural and light microscopic evidence of apoptosis after middle cerebral artery occlusion in the rat.

1995 • 258 citations

International trends in stroke mortality: 1970-1985.

1990 • 255 citations

Critical levels of extracellular glutamate mediating gerbil hippocampal delayed neuronal death during hypothermia: Brain microdialysis study

1991 • 251 citations

Induction of Spreading Depression in the Ischemic Hemisphere following Experimental Middle Cerebral Artery Occlusion: Effect on Infarct Morphology

1996 • 251 citations

Apolipoprotein E and alzheimer's disease: Ethnic variation in genotypic risks

1995 • 247 citations

The N-methyl-d-aspartate antagonists CGS 19755 and CPP reduce ischemic brain damage in gerbils

1988 • 246 citations

Attenuation of Stroke Size in Rats Using an Adenoviral Vector to Induce Overexpression of Interleukin-1 Receptor Antagonist in Brain

1995 • 245 citations

Outcome Model of Asphyxial Cardiac Arrest in Rats

1995 • 245 citations

Epidemiology of Stroke

2004 • 241 citations

Inhibition of Nitric Oxide Synthesis Increases Focal Ischemic Infarction in Rat

1992 • 239 citations

Rapid Communication: Regional Variability in DNA Fragmentation After Global Ischemia Evidenced by Combined Histological and Gel Electrophoresis Observations in the Rat Brain

1993 • 235 citations

Improving the outcome of severe head injury with the oxygen radical scavenger polyethylene glycol-conjugated superoxide dismutase: a Phase II trial

1993 • 234 citations

Clinical trial of nimodipine in acute ischemic stroke. The American Nimodipine Study Group.

1992 • 233 citations

Delayed Postischemic Hyperthermia in Awake Rats Worsens the Histopathological Outcome of Transient Focal Cerebral Ischemia

1996 • 233 citations

Anti‐CD11b monoclonal antibody reduces ischemic cell damage after transient focal cerebral ischemia in rat

1994 • 231 citations

Oxygen radicals in CNS damage

1989 • 226 citations

Rapid Preconditioning Protects Rats against Ischemic Neuronal Damage after 3 but Not 7 Days of Reperfusion following Global Cerebral Ischemia

1997 • 225 citations

Induction of Ischemic Tolerance following Brief Focal Ischemia in Rat Brain

1994 • 223 citations

Brain edema during ischemia and after restoration of blood flow. Measurement of water, sodium, potassium content and plasma protein permeability.

1979 • 222 citations

Changes in Amino Acid Neurotransmitters and Cerebral Blood Flow in the Ischemic Penumbral Region following Middle Cerebral Artery Occlusion in the Rat: Correlation with Histopathology

1993 • 220 citations

Basic Fibroblast Growth Factor Protects against Hypoxia-Ischemia and NMDA Neurotoxicity in Neonatal Rats

1993 • 218 citations

Therapeutic Potential of the Lazaroids (21-Aminosteroids) in Acute Central Nervous System Trauma, Ischemia and Subarachnoid Hemorrhage

1994 • 217 citations

Endonuclease activation following focal ischemic injury in the rat brain

1993 • 211 citations

Ischemia triggers NMDA receptor-linked cytoskeletal proteolysis in hippocampus

1989 • 209 citations

Nitric Oxide Donors Increase Blood Flow and Reduce Brain Damage in Focal Ischemia: Evidence That Nitric Oxide is Beneficial in the Early Stages of Cerebral Ischemia

1994 • 206 citations

MK-801 reduced cerebral ischemic injury by inducing hypothermia

1990 • 205 citations

The excitotoxin hypothesis in relation to cerebral ischemia.

1991 • 204 citations

Neurotrophic Factors in Central Nervous System Trauma

1995 • 204 citations

Monoclonal Antibody to the ICAM-1 Adhesion Site Reduces Neurological Damage in a Rabbit Cerebral Embolism Stroke Model

1993 • 202 citations

Photochemically induced cerebral infarction

1987 • 202 citations

Lubeluzole Treatment of Acute Ischemic Stroke

1997 • 197 citations

Apolipoprotein E ϵ4 and the Risk of Dementia With Stroke<subtitle>A Population-Based Investigation</subtitle>

1997 • 195 citations

Brain temperature monitoring and modulation in patients with severe MCA infarction

1997 • 195 citations

A New Rat Model of Thrombotic Focal Cerebral Ischemia

1997 • 184 citations

Hyperthermia delayed by 24 hours aggravates neuronal damage in rat hippocampus following global ischemia

1997 • 184 citations

Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia.

1994 • 183 citations

BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage.

1993 • 180 citations

Delayed Treatment with Intravenous Basic Fibroblast Growth Factor Reduces Infarct Size following Permanent Focal Cerebral Ischemia in Rats

1995 • 180 citations

Duration of Glutamate Release After Acute Ischemic Stroke

1997 • 179 citations

Effect of pretreatment with the calcium antagonist nimodipine on local cerebral blood flow and histopathology after middle cerebral artery occlusion

1985 • 173 citations

Postischemic Administration of AK275, a Calpain Inhibitor, Provides Substantial Protection against Focal Ischemic Brain Damage

1994 • 173 citations

Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo

1993 • 170 citations

Pharmacology of cerebral ischemia

1995 • 163 citations

Hypothermia prevents ischemia-induced increases in hippocampal glycine concentrations in rabbits.

1991 • 162 citations

Prevalence of apolipoprotein E phenotypes in ischemic cerebrovascular disease. A case-control study.

1993 • 162 citations

Meta-Analysis of Oral Nimodipine Trials in Acute Ischemic Stroke

1994 • 160 citations

Experimental Antileukocyte Interventions in Cerebral Ischemia

1996 • 158 citations

Lubeluzole in Acute Ischemic Stroke

1996 • 157 citations

Global Cerebral Ischemia Associated with Cardiac Arrest in the Rat: I. Dynamics of Early Neuronal Changes

1992 • 156 citations

Brain cell death following ischemia and reperfusion

1988 • 156 citations

N‐Methyl‐D‐Aspartate antagonist reduces stroke size and regional glucose metabolism

1990 • 155 citations

Effect of mild hyperthermia on the ischemic infarct volume after middle cerebral artery occlusion in the rat

1991 • 155 citations

Do NMDA antagonists protect against cerebral ischemia: are clinical trials warranted?

1990 • 154 citations

Pretreatment with intraventricular basic fibroblast growth factor decreases infarct size following focal cerebral ischemia in rats

1994 • 153 citations

Massive Persistent Release of Excitatory Amino Acids Following Human Occlusive Stroke

1995 • 151 citations

Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion‐weighted MRI

1993 • 150 citations

A Randomized Trial of Tirilazad Mesylate in Patients With Acute Stroke (RANTTAS)

1996 • 149 citations

Nimodipine and the Haemodynamic and Histopathological Consequences of Middle Cerebral Artery Occlusion in the Rat

1986 • 147 citations

Tirilazad reduces cortical infarction after transient but not permanent focal cerebral ischemia in rats.

1992 • 146 citations

“Brain Attack”: The Rationale for Treating Stroke as a Medical Emergency

1994 • 141 citations

GM1 ganglioside therapy in acute ischemic stroke. Italian Acute Stroke Study--Hemodilution + Drug.

1989 • 140 citations

Recirculation model following MCA occlusion in rats

1985 • 137 citations

Photochemically induced cerebral infarction

1987 • 136 citations

THE PROGNOSTIC SIGNIFICANCE of SUBFEBRILITY and FEVER IN ISCHAEMIC CEREBRAL INFARCTION

1976 • 134 citations

Brain damage and temperature: cellular and molecular mechanisms.

1996 • 133 citations

Assessment of cerebral haemodynamic reserve: correlation between PET parameters and CO2 reactivity measured by the intravenous 133 xenon injection technique.

1988 • 130 citations

Moderate hypothermia after cardiac arrest of 17 minutes in dogs. Effect on cerebral and cardiac outcome.

1990 • 122 citations

Nitric Oxide in Cells

1992 • 121 citations

p53 Expression in brain after middle cerebral artery occlusion in the rat

1992 • 120 citations

Different susceptibilities to cerebral infarction in spontaneously hypertensive (SHR) and normotensive Sprague-Dawley rats.

1986 • 120 citations

Nimodipine attenuates both increase in cytosolic free calcium and histologic damage following focal cerebral ischemia and reperfusion in cats.

1989 • 120 citations

Apolipoprotein E4 Phenotype Is Not an Important Risk Factor for Coronary Heart Disease or Stroke in Elderly Subjects

1995 • 117 citations

Differences in DNA Fragmentation following Transient Cerebral or Decapitation Ischemia in Rats

1995 • 116 citations

The Role of Brain-derived Neurotrophic Factor in Transient Forebrain Ischemia in the Rat Brain

1994 • 115 citations

The Heat Shock/Stress Response in Focal Cerebral Ischemia

1994 • 114 citations

Effect of Delayed MK-801 (Dizocilpine) Treatment with or without Immediate Postischemic Hypothermia on Chronic Neuronal Survival after Global Forebrain Ischemia in Rats

1995 • 114 citations

The effect of nitric oxide synthase inhibition on infarct volume after reversible focal cerebral ischemia in conscious rats.

1993 • 112 citations

Photothrombotic Infarction Triggers Multiple Episodes of Cortical Spreading Depression in Distant Brain Regions

1994 • 111 citations

Fatal ischaemic brain oedema after early thrombolysis with tissue plasminogen activator in acute stroke.

1988 • 109 citations

Possible involvement of interleukin-1 in ischemic brain edema formation

1992 • 108 citations

Reduction of glutamate release and protection against ischemic brain damage by BW 1003C87

1992 • 107 citations

Gene Expression from Recombinant Viral Vectors in the Central Nervous System after Blood-Brain Barrier Disruption

1995 • 107 citations

Changes in Extracellular Amino Acids and Spontaneous Neuronal Activity During Ischemia and Extended Reflow in the CA1 of the Rat Hippocampus

1991 • 104 citations

Clinical trial of nimodipine in acute ischemic stroke

1992 • 104 citations

Ischemia-induced slowly progressive neuronal damage in the rat brain

1990 • 102 citations

The status of alcohol as a risk factor for stroke.

1989 • 101 citations

Gene Therapy for Cerebral Vascular Disease

1996 • 101 citations

The Pathogenesis of Transient Focal Cerebral Ischemia

1965 • 97 citations

The neural cell spectrin skeleton: a review

1986 • 95 citations

Photochemically Induced Cortical Infarction in the Rat. 1. Time Course of Hemodynamic Consequences

1986 • 94 citations

Neocortical localization of tactile/proprioceptive limb placing reactions in the rat

1992 • 93 citations

Argon laser-induced arterial photothrombosis

1987 • 90 citations

Early treatment of stroke with monosialoganglioside GM-1. Efficacy and safety results of the Early Stroke Trial.

1994 • 87 citations

Lubeluzole protects sensorimotor function and reduces infarct size in a photochemical stroke model in rats.

1996 • 86 citations

Animal stroke models. They are relevant to human disease.

1990 • 83 citations

Asphyxia, cardiac arrest and resuscitation in rats. I. Short term recovery

1984 • 83 citations

The role of nitric oxide in the pathophysiology of thromboembolic stroke in the rat

1997 • 79 citations

REVIEW ■ : Neuroprotection in Brain Ischemia: An Update (Part I

1995 • 77 citations

Hyperthermia enhances spectrin breakdown in transient focal cerebral ischemia

1997 • 77 citations

Fever and cerebral vasospasm in ruptured intracranial aneurysms.

1980 • 76 citations

The Role of Neurotransmitters in Brain Injury

1992 • 74 citations

Flunarizine reduces cerebral infarct size after photochemically induced thrombosis in spontaneously hypertensive rats.

1987 • 71 citations

Preventing stroke by the modification of risk factors.

1990 • 71 citations

Photothrombotic Occlusion of Rat Middle Cerebral Artery: Histopathological and Hemodynamic Sequelae of Acute Recanalization

1988 • 68 citations

Transient Blood-Brain Barrier Permeability following Profound Temporary Global Ischaemia: An Experimental Study Using ¹⁴C-AIB

1989 • 67 citations

Histopathological and Hemodynamic Consequences of Complete versus Incomplete Ischemia in the Rat

1987 • 67 citations

Photochemically Induced Cortical Infarction in the Rat. 2. Acute and Subacute Alterations in Local Glucose Utilization

1986 • 65 citations

Distribution of atherosclerotic cerebrovascular lesions. Effects of age, race, and sex.

1993 • 64 citations

Embolic stroke from a carotid arterial source in the rat

1989 • 62 citations

Double‐blind evaluation of monosialoganglioside (GM₁) therapy in stroke

1984 • 60 citations

The Evolution of Brain Infarcts. A Review

1992 • 60 citations

Effects of Nitric Oxide Synthase Inhibition on Cerebral Blood Flow following Bilateral Carotid Artery Occlusion and Recirculation in the Rat

1993 • 59 citations

Safety study of tirilazad mesylate in patients with acute ischemic stroke (STIPAS).

1994 • 58 citations

Lack of Protection by the N-Methyl-D-aspartate Receptor Blocker Dizocilpine (MK-801) after Transient Severe Cerebral Ischemia in the Rat

1991 • 55 citations

Review : Neuroprotection in Brain Ischemia: An Update (Part II

1995 • 54 citations

A simple and reproducible cerebral thrombosis model in rats induced by a photochemical reaction and the effect of a plasminogen-plasminogen activator chimera in this model

1993 • 53 citations

Effects of GM<sub>1</sub> Ganglioside in Cerebrovascular Diseases: A Double-Blind Trial in 40 Cases

1985 • 51 citations

Bilateral ischemic tolerance of rat hippocampus induced by prior unilateral transient focal ischemia

1996 • 51 citations

The Validity of Rodent Brain-Ischemia Models Is Self-evident

1996 • 49 citations

Microvascular and Neuronal Consequences of Common Carotid Artery Thrombosis and Platelet Embolization in Rats

1993 • 48 citations

Combination therapy with nimodipine and dizocilpine in a rat model of transient forebrain ischemia.

1992 • 48 citations

Morphological consequences of early reperfusion following thrombotic or mechanical occlusion of the rat middle cerebral artery

1989 • 48 citations

Modulation of Ornithine Decarboxylase mRNA following Transient Ischemia in the Gerbil Brain

1991 • 48 citations

Transient platelet accumulation in the rat brain after common carotid artery thrombosis. An 111In-labeled platelet study.

1993 • 45 citations

Nonocclusive Common Carotid Artery Thrombosis in the Rat Results in Reversible Sensorimotor and Cognitive Behavioral Deficits

1995 • 44 citations

Cellular and molecular mechanisms of ischemic brain damage

1996 • 41 citations

Delayed Treatment with a Noncompetitive NMDA Antagonist, CNS-1102, Reduces Infarct Size in Rats

1993 • 40 citations

Sensory-motor deficit and recovery from thrombotic infarction of the vibrissal barrel-field cortex

1990 • 40 citations

Calcium antagonists in the management of subarachnoid haemorrhage.

1990 • 39 citations

Postresuscitation disease

1984 • 38 citations

Oral contraceptives and stroke.

1984 • 35 citations

Monosialoganglioside GM1 in cerebral ischemia.

1991 • 34 citations

An overview of stroke rehabilitation.

1990 • 34 citations

Postischemic (S)-emopamil therapy ameliorates focal ischemic brain injury in rats.

1991 • 33 citations

Effect of the Serotonin Antagonist Ketanserin on the Hemodynamic and Morphological Consequences of Thrombotic Infarction

1989 • 32 citations

A comparison of trends in mortality from stroke in the United States and Rochester, Minnesota.

1982 • 31 citations

L-Arginine Does Not Improve Cortical Perfusion or Histopathological Outcome in Spontaneously Hypertensive Rats Subjected to Distal Middle Cerebral Artery Photothrombotic Occlusion

1996 • 30 citations

Brain enzyme changes as markers of brain damage in rat cardiac arrest model. Effects of corticosteroid therapy

1989 • 30 citations

Reduction of Cerebral Blood Flow and Oxygen Consumption with a Combination of Barbiturate Anaesthesia and Induced Hypothermia in the Rat

1978 • 29 citations

Intravenous Nimodipine in Acute Ischaemic Stroke

1994 • 28 citations

Inflammatory Cytokines and Stroke: Emerging New Strategies for Stroke Therapeutics

1995 • 21 citations

Mitigation of evolving cortical infarction in rats by recombinant tissue plasminogen activator following photochemically induced thrombosis

1987 • 19 citations

Induction of Early-Response Genes after Focal Ischemia

1993 • 14 citations

The Blood-Brain Barrier in Brain Injury: An Overview

1992 • 13 citations

Recovery of vibrissae-dependent behavioral responses following barrelfield damage is not dependent upon the remaining somatosensory cortical tissue

1995 • 11 citations

Central Nervous System Trauma

1996 • 10 citations

Changing incidence and mortality rates for stroke

1992 • 7 citations

Epidemiology and Trials

1995 • 3 citations

Deleted Work

1955 • 0 citations