Inhibition of ErbB2 causes mitochondrial dysfunction in cardiomyocytes

Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2

2001 • 11,070 citations

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

2002 • 1,617 citations

BAX and BAK Regulation of Endoplasmic Reticulum Ca ²⁺ : A Control Point for Apoptosis

2003 • 1,363 citations

ErbB2 is essential in the prevention of dilated cardiomyopathy

2002 • 875 citations

A mechanistic role for cardiac myocyte apoptosis in heart failure

2003 • 718 citations

Modulation of cell death by Bcl-x _L through caspase interaction

1998 • 505 citations

Bcl-xL Prevents Cell Death following Growth Factor Withdrawal by Facilitating Mitochondrial ATP/ADP Exchange

1999 • 496 citations

Neuregulins Promote Survival and Growth of Cardiac Myocytes

1998 • 493 citations

Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy

2002 • 461 citations

Adenoviral Gene Transfer of Activated Phosphatidylinositol 3′-Kinase and Akt Inhibits Apoptosis of Hypoxic Cardiomyocytes In Vitro

1999 • 381 citations

Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex

1997 • 366 citations

Bcl-x Promotes the Open Configuration of the Voltage-dependent Anion Channel and Metabolite Passage through the Outer Mitochondrial Membrane

2001 • 356 citations

Trastuzumab‐associated cardiotoxicity

2002 • 346 citations

Akt and Bcl-xL Promote Growth Factor-independent Survival through Distinct Effects on Mitochondrial Physiology

2001 • 309 citations

Energy metabolism in the normal and failing heart: potential for therapeutic interventions.

2002 • 271 citations

Cardiac reperfusion injury: Aging, lipid peroxidation, and mitochondrial dysfunction

1998 • 260 citations

Mitochondria: a target for myocardial protection

2001 • 244 citations

Energy Metabolism during Apoptosis

1997 • 206 citations

Biological rationale for HER2/neu (c-erbB2) as a target for monoclonal antibody therapy.

2000 • 147 citations

Reversal of permeability transition during recovery of hearts from ischemia and its enhancement by pyruvate

1999 • 140 citations

High extracellular glucose impairs cardiac E-C coupling in a glycosylation-dependent manner

1997 • 114 citations

BH4-domain peptide from Bcl-xL exerts anti-apoptotic activity in vivo

2003 • 103 citations

The role of apoptosis in myocardial ischemia: a critical appraisal

2001 • 97 citations

NH2-terminal BH4 Domain of Bcl-2 Is Functional for Heterodimerization with Bax and Inhibition of Apoptosis

1999 • 93 citations

Apoptotic pathway activation from mitochondria and death receptors without caspase-3 cleavage in failing human myocardium

2002 • 88 citations

APOPTOSIS AND THE SYSTOLIC DYSFUNCTION IN CONGESTIVE HEART FAILURE

2001 • 81 citations

Gα _i2 but Not Gα _i3 Is Required for Muscarinic Inhibition of Contractility and Calcium Currents in Adult Cardiomyocytes

2000 • 69 citations

Involvement of the neuregulins and their receptors in cardiac and neural development

1996 • 39 citations

Apoptosis of Cardiomyocytes in Explanted and Transplanted Hearts

2004 • 30 citations

Mitochondrial plasticity in classical ischemic preconditioning—moving beyond the mitochondrial KATP channel

2003 • 29 citations

Mutation of the human neu protein facilitates down-modulation by monoclonal antibodies.

1990 • 25 citations

Absence of autophosphorylation site Y882 in the p185neu oncogene product correlates with a reduction of transforming potential

1998 • 23 citations

Cytochrome c Depletion upon Expression of Bcl-XS

2001 • 19 citations

Mitochondrial NAD(P)H, ADP, oxidative phosphorylation, and contraction in isolated heart cells

2000 • 17 citations