Apoptotic pathway activation from mitochondria and death receptors without caspase-3 cleavage in failing human myocardium

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

IAP family proteins---suppressors of apoptosis

1999 • 2,570 citations

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

1997 • 1,851 citations

Endonuclease G is an apoptotic DNase when released from mitochondria

2001 • 1,725 citations

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

2001 • 1,327 citations

Caspase-3-Generated Fragment of Gelsolin: Effector of Morphological Change in Apoptosis

1997 • 1,233 citations

Pathophysiologically Relevant Concentrations of Tumor Necrosis Factor-α Promote Progressive Left Ventricular Dysfunction and Remodeling in Rats

1998 • 810 citations

Apoptosis in heart failure: Release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy

1999 • 573 citations

Apoptosis and Heart Failure

2000 • 512 citations

Direct Evidence for Increased Hydroxyl Radicals Originating From Superoxide in the Failing Myocardium

2000 • 423 citations

Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction

2000 • 423 citations

Myocyte Death in the Failing Human Heart Is Gender Dependent

1999 • 404 citations

Mitochondrial Nitric-oxide Synthase Stimulation Causes Cytochrome c Release from Isolated Mitochondria

1999 • 333 citations

Significance of Myocytes With Positive DNA In Situ Nick End-Labeling (TUNEL) in Hearts With Dilated Cardiomyopathy

1999 • 321 citations

Mitochondrial role in life and death of the cell

2000 • 304 citations

A Caspase-9 Variant Missing the Catalytic Site Is an Endogenous Inhibitor of Apoptosis

1999 • 179 citations

Myocardial Gene Expression of Regulators of Myocyte Apoptosis and Myocyte Calcium Homeostasis During Hemodynamic Unloading by Ventricular Assist Devices in Patients With End-Stage Heart Failure

1999 • 155 citations

Apoptosis in heart failure

1998 • 132 citations

Human myocardial ATP content and in vivo contractile function

1998 • 122 citations

Tumor Necrosis Factor-α (TNF-α) Plays a Protective Role in Acute Viral Myocarditis in Mice

2001 • 119 citations

Gelsolin in Complex with Phosphatidylinositol 4,5-Bisphosphate Inhibits Caspase-3 and -9 to Retard Apoptotic Progression

2000 • 111 citations

Untitled

1998 • 104 citations

An overview of tumor necrosis factor α and the failing human heart

1999 • 95 citations

Response of hypertrophied myocardium to ischemia

1981 • 94 citations

Transforming Growth Factor β Induces Caspase 3-independent Cleavage of αII-Spectrin (α-Fodrin) Coincident with Apoptosis

1999 • 74 citations

Additional use of immunostaining for active caspase 3 and cleaved actin and PARP fragments to detect apoptosis in patients with chronic heart failure

2000 • 65 citations

Myocardial Gene Expression of Regulators of Myocyte Apoptosis and Myocyte Calcium Homeostasis During Hemodynamic Unloading by Ventricular Assist Devices in Patients With End-Stage Heart Failure

1999 • 43 citations

Left Ventricular Assist System Support Is Associated With Persistent Inflammation and Temporary Immunosuppression

1999 • 40 citations

FP‐receptor mediated trophic effects of prostanoids in rat ventricular cardiomyocytes

2000 • 31 citations

Untitled

1999 • 23 citations

Age-Dependent Myocardial Reinduction of Apoptosis Inhibitors under VAD in Heart Failure*

2001 • 3 citations