The role of apoptosis in myocardial ischemia: a critical appraisal

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

The mitochondrial permeability transition pore and its role in cell death

1999 • 2,326 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

Mitochondria as the central control point of apoptosis

2000 • 1,875 citations

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.

1994 • 1,431 citations

Mechanisms of Apoptosis

2000 • 1,249 citations

Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats.

1996 • 1,045 citations

Apoptosis in Human Acute Myocardial Infarction

1997 • 825 citations

Apoptosis in heart failure: Release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy

1999 • 573 citations

Acute Myocardial Infarction in Humans is Associated with Activation of Programmed Myocyte Cell Death in the Surviving Portion of the Heart

1996 • 515 citations

Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell.

1998 • 460 citations

Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction

2000 • 423 citations

Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines.

1992 • 401 citations

Hibernating Myocardium

1997 • 367 citations

Programmed Myocyte Cell Death Affects the Viable Myocardium after Infarction in Rats

1996 • 340 citations

“Apoptotic” Myocytes in Infarct Area in Rabbit Hearts May Be Oncotic Myocytes With DNA Fragmentation

1998 • 316 citations

The Mitochondrial Apoptotic Pathway Is Activated by Serum and Glucose Deprivation in Cardiac Myocytes

1999 • 271 citations

Ultrastructural morphometric analysis of myocardium from dogs, rats, hamsters, mice, and from human hearts.

1985 • 264 citations

The bcl-2 Gene Product Prevents Programmed Cell Death of Ventricular Myocytes

1997 • 225 citations

Presence of double-strand breaks with single-base 3' overhangs in cells undergoing apoptosis but not necrosis.

1996 • 193 citations

Effect of caspase inhibitors on myocardial infarct size and myocyte DNA fragmentation in the ischemia–reperfused rat heart

2000 • 142 citations

Unresolved Issues Regarding the Role of Apoptosis in the Pathogenesis of Ischemic Injury and Heart Failure

2000 • 139 citations

Postmitochondrial regulation of apoptosis during heart failure

1999 • 113 citations

Inhibition of the ER-Kinase Cascade by PD98059 and UO126 Counteracts Ischemic Preconditioning in Pig Myocardium

2000 • 110 citations

Time Course of the Apoptotic Cascade and Effects of Caspase Inhibitors in Adult Rat Ventricular Cardiomyocytes

2001 • 100 citations

c-Jun Triggers Apoptosis in Human Vascular Endothelial Cells

1999 • 92 citations

Coronary artery constriction in rats: necrotic and apoptotic myocyte death

1998 • 43 citations

[Ischemic heart disease and apoptosis].

1997 • 10 citations