APOPTOSIS AND THE SYSTOLIC DYSFUNCTION IN CONGESTIVE HEART FAILURE

Effect of Enalapril on Survival in Patients with Reduced Left Ventricular Ejection Fractions and Congestive Heart Failure

1991 • 8,296 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications.

1990 • 2,864 citations

The epidemiology of heart failure: The Framingham Study

1993 • 2,278 citations

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

1997 • 1,851 citations

Apoptosis in the Failing Human Heart

1997 • 1,690 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

Apoptosis in Myocytes in End-Stage Heart Failure

1996 • 1,446 citations

Intracellular ATP levels determine cell death fate by apoptosis or necrosis.

1997 • 1,218 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group.

1990 • 1,151 citations

Effects of the Early Administration of Enalapril on Mortality in Patients with Acute Myocardial Infarction

1992 • 968 citations

Catecholamine cardiotoxicity

1985 • 692 citations

Progressive left ventricular dysfunction and remodeling after myocardial infarction. Potential mechanisms and early predictors.

1993 • 692 citations

Stretch-induced programmed myocyte cell death.

1995 • 647 citations

Afterload mismatch and preload reserve: A conceptual framework for the analysis of ventricular function

1976 • 634 citations

Effects of the angiotensin converting enzyme inhibitor enalapril on the long-term progression of left ventricular dysfunction in patients with heart failure. SOLVD Investigators.

1992 • 608 citations

Structural basis of end-stage failure in ischemic cardiomyopathy in humans.

1994 • 583 citations

Prognosis after initial myocardial infarction: The Framingham study

1979 • 580 citations

Apoptosis in heart failure: Release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy

1999 • 573 citations

Enhanced Gαq signaling: A common pathway mediates cardiac hypertrophy and apoptotic heart failure

1998 • 528 citations

Apoptosis and Heart Failure

2000 • 512 citations

Cytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced Apoptosis

2000 • 501 citations

Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy.

1997 • 496 citations

Apoptosis in pressure overload-induced heart hypertrophy in the rat.

1996 • 416 citations

Cardiac myocyte necrosis induced by angiotensin II.

1991 • 383 citations

Expression of bcl-2 Protein, an Inhibitor of Apoptosis, and Bax, an Accelerator of Apoptosis, in Ventricular Myocytes of Human Hearts With Myocardial Infarction

1996 • 367 citations

Programmed Myocyte Cell Death Affects the Viable Myocardium after Infarction in Rats

1996 • 340 citations

Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure.

1996 • 335 citations

Significance of Myocytes With Positive DNA In Situ Nick End-Labeling (TUNEL) in Hearts With Dilated Cardiomyopathy

1999 • 321 citations

Early prevention of left ventricular dysfunction after myocardial infarction with angiotensin-converting-enzyme inhibition

1991 • 307 citations

Increased cardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive rat

1997 • 304 citations

A canine model of chronic heart failure produced by multiple sequential coronary microembolizations

1991 • 291 citations

The cellular basis of dilated cardiomyopathy in humans

1995 • 261 citations

Calcineurin-Mediated Hypertrophy Protects Cardiomyocytes From Apoptosis In Vitro and In Vivo

2000 • 228 citations

The Cardiomyopathy of Overload: An Unnatural Growth Response in the Hypertrophied Heart

1994 • 218 citations

Structural remodeling and mechanical dysfunction of cardiac myocytes in heart failure

1995 • 218 citations

Myocyte nuclear mitotic division and programmed myocyte cell death characterize the cardiac myopathy induced by rapid ventricular pacing in dogs.

1995 • 209 citations

Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo.

1997 • 207 citations

Effects of long-term monotherapy with enalapril, metoprolol, and digoxin on the progression of left ventricular dysfunction and dilation in dogs with reduced ejection fraction.

1994 • 207 citations

The Cellular Basis of Pacing-Induced Dilated Cardiomyopathy

1995 • 198 citations

Apoptosis of Cardiac Myocytes in Gsα Transgenic Mice

1999 • 168 citations

Heart failure in the 1990s: Evolutions of a major public health problem in cardiovascular medicine

1993 • 163 citations

Plasma Fas Ligand, an Inducer of Apoptosis, and Plasma Soluble Fas, an Inhibitor of Apoptosis, in Patients With Chronic Congestive Heart Failure

1997 • 158 citations

Myocardial Gene Expression of Regulators of Myocyte Apoptosis and Myocyte Calcium Homeostasis During Hemodynamic Unloading by Ventricular Assist Devices in Patients With End-Stage Heart Failure

1999 • 155 citations

Ventricular enlargement and reduced survival after myocardial infarction.

1987 • 145 citations

Fas-ligand: Privilege and peril

1997 • 142 citations

Unresolved Issues Regarding the Role of Apoptosis in the Pathogenesis of Ischemic Injury and Heart Failure

2000 • 139 citations

Survival of patients with congestive heart failure: past, present, and future prospects.

1987 • 138 citations

Isolated Myocyte Contractile Function Is Normal in Postinfarct Remodeled Rat Heart With Systolic Dysfunction

1997 • 125 citations

Effects of ACE inhibition on cardiomyocyte apoptosis in dogs with heart failure

1998 • 121 citations

β-Adrenergic receptor blockade arrests myocyte damage and preserves cardiac function in the transgenic Gsα mouse

1999 • 120 citations

Postmitochondrial regulation of apoptosis during heart failure

1999 • 113 citations

Myocardial Cell Death and Apoptosis in Hibernating Myocardium

1997 • 106 citations

Apoptosis and cardiomyopathy

2000 • 105 citations

Chronic therapy with metoprolol attenuates cardiomyocyte apoptosis in dogs with heart failure

2000 • 104 citations

Effect of prolonged nitrate therapy on left ventricular remodeling after canine acute myocardial infarction.

1994 • 87 citations

From coronary artery disease to heart failure: Role of the hibernating myocardium

1995 • 83 citations

Relation between beta-adrenergic blocker use, various correlates of left ventricular function and the chance of developing congestive heart failure

1990 • 75 citations

Hemodynamic, left ventricular structural and hormonal changes after discrete myocardial damage in the dog

1992 • 66 citations

Changes in ventricular volume, wall thickness and wall stress during progression of left ventricular dysfunction

1993 • 47 citations

The cardiomyopathy of overload: An unnatural growth response

1995 • 47 citations

Angiotensin converting enzyme inhibitors and cardiovascular remodelling

1994 • 44 citations

Left ventricular hypertrophy: An initial response to myocardial injury

1992 • 44 citations

[Ca2+]i transients in hypertensive and postinfarction myocytes

1995 • 42 citations

Alternative Splicing of the Primary Fas Transcript Generating Soluble Fas Antagonists Is Suppressed in the Failing Human Ventricular Myocardium

1997 • 41 citations

Altered Levels of mRNA of Apoptosis-Mediating Genes After Mid-Term Mechanical Ventricular Support in Dilative Cardiomyopathy - First Results of the Halle Assist Induced Recovery Study (HAIR)

1999 • 38 citations

Hypothetical pathways of cardiac myocyte hypertrophy: response to myocardial injury.

1993 • 20 citations