Mitochondrial plasticity in classical ischemic preconditioning—moving beyond the mitochondrial KATP channel

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.

1986 • 7,740 citations

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

Cardioprotective Effect of Diazoxide and Its Interaction With Mitochondrial ATP-Sensitive K ⁺ Channels

1997 • 1,032 citations

Mitochondrial ATP-Dependent Potassium Channels

1998 • 825 citations

Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode.

1990 • 777 citations

Oxidant Signaling in Vascular Cell Growth, Death, and Survival

2000 • 742 citations

Reactive Oxygen Species Released from Mitochondria during Brief Hypoxia Induce Preconditioning in Cardiomyocytes

1998 • 715 citations

The Mitochondrial Production of Reactive Oxygen Species: Mechanisms and Implications in Human Pathology

2001 • 584 citations

Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?

2002 • 579 citations

Cytoprotective Role of Ca ²⁺ - Activated K ⁺ Channels in the Cardiac Inner Mitochondrial Membrane

2002 • 478 citations

Modulation of Mitochondrial ATP-Dependent K ⁺ Channels by Protein Kinase C

1998 • 368 citations

Mitochondrial ATP-Sensitive Potassium Channels Attenuate Matrix Ca ²⁺ Overload During Simulated Ischemia and Reperfusion

2001 • 362 citations

Bioenergetic consequences of opening the ATP-sensitive K⁺channel of heart mitochondria

2001 • 355 citations

ATP‐sensitive K⁺ channel openers prevent Ca²⁺ overload in rat cardiac mitochondria

1999 • 353 citations

K_ATP channel‐independent targets of diazoxide and 5‐hydroxydecanoate in the heart

2002 • 323 citations

Mitochondrial ATP-sensitive K⁺channels modulate cardiac mitochondrial function

1998 • 313 citations

Developmental changes in energy substrate use by the heart

1992 • 298 citations

Mitochondrial ATP-Sensitive Potassium Channels Inhibit Apoptosis Induced by Oxidative Stress in Cardiac Cells

2001 • 281 citations

Mechanisms by which opening the mitochondrial ATP- sensitive K⁺channel protects the ischemic heart

2002 • 220 citations

Mitochondrial KATP channels: role in cardioprotection

2002 • 208 citations

Characteristics and Superoxide-Induced Activation of Reconstituted Myocardial Mitochondrial ATP-Sensitive Potassium Channels

2001 • 204 citations

Potassium channel openers protect cardiac mitochondria by attenuating oxidant stress at reoxygenation

2002 • 202 citations

Protection of cardiac mitochondria by diazoxide and protein kinase C: Implications for ischemic preconditioning

2002 • 182 citations

Relation of mitochondrial and cytosolic free calcium to cardiac myocyte recovery after exposure to anoxia.

1992 • 177 citations

Dinitrophenol, cyclosporin A, and trimetazidine modulate preconditioning in the isolated rat heart: support for a mitochondrial role in cardioprotection

2000 • 163 citations

Cardioprotection by Ischemic Preconditioning Preserves Mitochondrial Function and Functional Coupling Between Adenine Nucleotide Translocase and Creatine Kinase

2001 • 113 citations

Metabolic Plasticity and the Promotion of Cardiac Protection in Ischemia and Ischemic Preconditioning

2002 • 110 citations

Ischemic and Pharmacological Preconditioning in Girardi Cells and C2C12 Myotubes Induce Mitochondrial Uncoupling

2001 • 90 citations

Rapid stimulation of glucose transport by mitochondrial uncoupling depends in part on cytosolic Ca²⁺ and cPKC

1998 • 87 citations

Opening of Mitochondrial K _ATP Channels Attenuates the Ouabain-Induced Calcium Overload in Mitochondria

2001 • 86 citations

Diazoxide, an inhibitor of succinate oxidation

1969 • 86 citations

Diazoxide protects mitochondria from anoxic injury: Implications for myopreservation

2001 • 83 citations

Diazoxide Opens the Mitochondrial Permeability Transition Pore and Alters Ca ²⁺ Transients in Rat Ventricular Myocytes

2002 • 76 citations

Chemical preconditioning with 3-nitropropionic acid in hearts: role of mitochondrial K_ATPchannel

2001 • 73 citations

Do Modulators of the Mitochondrial KATP Channel Change the Function of Mitochondria in Situ?

2000 • 63 citations

Dinitrophenol Pretreatment of Rat Ventricular Myocytes Protects Against Damage by Metabolic Inhibition and Reperfusion

2002 • 57 citations

Regulation of the mitochondrial permeability transition by matrix Ca²⁺ and voltage during anoxia/reoxygenation

2001 • 51 citations

Close Association Between the Reduction in Myocardial Energy Metabolism and Infarct Size: Dose-Response Assessment of Cyclosporine

2002 • 41 citations