MLL fusion genes in the 11q23 acute leukemias

DNA TOPOISOMERASES

1985 • 1,524 citations

Catalog of chromosome aberrations in cancer

1985 • 1,522 citations

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

1992 • 944 citations

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

1992 • 850 citations

Acute Myeloid Leukemia in Children Treated with Epipodophyllotoxins for Acute Lymphoblastic Leukemia

1991 • 723 citations

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.

1991 • 602 citations

Lineage promiscuity in hemopoietic differentiation and leukemia

1986 • 572 citations

Rearrangement of the MLL Gene in Acute Lymphoblastic and Acute Myeloid Leukemias with 11q23 Chromosomal Translocations

1993 • 523 citations

Secondary Acute Myeloid Leukemia in Children Treated for Acute Lymphoid Leukemia

1989 • 457 citations

In utero rearrangements in the trithorax-related oncogene in infant leukaemias

1993 • 450 citations

Human acute leukemia cell line with the t(4;11) chromosomal rearrangement exhibits B lineage and monocytic characteristics

1985 • 331 citations

Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA- topoisomerase II

1993 • 319 citations

Chromosomal abnormalities identify high-risk and low-risk patients with acute lymphoblastic leukemia

1986 • 308 citations

Clinical characteristics and treatment outcome of childhood acute lymphoblastic leukemia with the t(4;11)(q21;q23): a collaborative study of 40 cases [see comments]

1991 • 307 citations

Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.

1993 • 297 citations

Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome

1993 • 294 citations

Current status of cytogenetic research in childhood acute lymphoblastic leukemia

1993 • 284 citations

Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation.

1993 • 260 citations

Mapping chromosome band 11q23 in human acute leukemia with biotinylated probes: identification of 11q23 translocation breakpoints with a yeast artificial chromosome.

1990 • 247 citations

11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene.

1994 • 241 citations

Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome

1993 • 236 citations

The Drosophila Polycomb-group gene Enhancer of zeste contains a region with sequence similarity to trithorax.

1993 • 235 citations

Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product.

1993 • 231 citations

Current status of cytogenetic research in childhood acute lymphoblastic leukemia

1993 • 223 citations

Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia.

1994 • 223 citations

ALL-1 partial duplication in acute leukemia.

1994 • 219 citations

11q23/MLL rearrangement confers a poor prognosis in infants with acute lymphoblastic leukemia.

1994 • 212 citations

Dysfunction of chromosomal loop attachment sites: illegitimate recombination linked to matrix association regions and topoisomerase II.

1989 • 206 citations

Catalog of Chromosome Aberrations in Cancer

1996 • 204 citations

The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein with zinc-binding domains.

1990 • 196 citations

Cloning of ALL-1, the locus involved in leukemias with the t(4;11)(q21;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13) chromosome translocations.

1991 • 185 citations

Frequency and prognostic significance of HRX rearrangements in infant acute lymphoblastic leukemia: a Pediatric Oncology Group study

1994 • 183 citations

PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors.

1994 • 175 citations

Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation.

1993 • 174 citations

Acute leukemia associated with the t(4;11) chromosome rearrangement: ultrastructural and immunologic characteristics

1982 • 171 citations

A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia

1995 • 169 citations

Illegitimate recombination mediated by calf thymus DNA topoisomerase II in vitro.

1988 • 168 citations

Molecular rearrangements of the MLL gene are present in most cases of infant acute myeloid leukemia and are strongly correlated with monocytic or myelomonocytic phenotypes.

1994 • 168 citations

ALL-1 tandem duplication in acute myeloid leukemia with a normal karyotype involves homologous recombination between Alu elements.

1994 • 167 citations

HRX involvement in de novo and secondary leukemias with diverse chromosome 11q23 abnormalities [see comments]

1993 • 166 citations

Clinical and hematologic characteristics in acute leukemia with 11q23 translocations

1986 • 162 citations

Molecular rearrangement of the ALL-1 gene in acute myeloid leukemia without cytogenetic evidence of 11q23 chromosomal translocations.

1994 • 158 citations

Cytogenetic features of infants less than 12 months of age at diagnosis of acute lymphoblastic leukemia: impact of the 11q23 breakpoint on outcome: a report of the Childrens Cancer Group

1994 • 156 citations

Cloning and characterization of the t(X;II) breakpoint from a leukemic cell line identify a new member of the forkhead gene family

1994 • 155 citations

Translocation 4; 11 in acute lymphoblastic leukemia: clinical characteristics and prognostic significance

1982 • 152 citations

Six-year follow-up of the clinical significance of karyotype in acute lymphoblastic leukemia

1989 • 149 citations

Sequence analysis of the breakpoint cluster region in the ALL-1 gene involved in acute leukemia.

1994 • 149 citations

Clinical and laboratory characteristics of acute leukemia with the 4;11 translocation

1986 • 140 citations

Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases.

1993 • 139 citations

Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia.

1994 • 137 citations

A novel gene, AF1q, fused to MLL in t(1;11) (q21;q23), is specifically expressed in leukemic and immature hematopoietic cells

1995 • 136 citations

ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells

1994 • 132 citations

A serine/proline-rich protein is fused to HRX in t(4;11) acute leukemias

1993 • 122 citations

Cytogenetics of childhood acute nonlymphocytic leukemia

1989 • 120 citations

Translocation 4; 11 in acute lymphoblastic leukemia: clinical characteristics and prognostic significance

1982 • 118 citations

Four cases of t(4;11) acute leukemia and its myelomonocytic nature in infants

1983 • 117 citations

Cloning of cDNAs of the MLL gene that detect DNA rearrangements and altered RNA transcripts in human leukemic cells with 11q23 translocations.

1992 • 110 citations

The (4;11)(q21;q23) chromosome translocations in acute leukemias involve the VDJ recombinase.

1992 • 109 citations

Detection of ALL-1/AF4 fusion transcript by reverse transcription- polymerase chain reaction for diagnosis and monitoring of acute leukemias with the t(4;11) translocation

1993 • 108 citations

Childhood acute lymphoblastic leukemia with chromosomal breakpoints at 11q23

1989 • 107 citations

Clonal, nonconstitutional rearrangements of the MLL gene in infant twins with acute lymphoblastic leukemia: in utero chromosome rearrangement of 11q23

1994 • 106 citations

Interferon and c- ets -1 Genes in the Translocation (9;11)(p22;q23) in Human Acute Monocytic Leukemia

1986 • 103 citations

Potential topoisomerase II DNA-binding sites at the breakpoints of a t(9;11) chromosome translocation in acute myeloid leukemia.

1993 • 101 citations

Chromosome pattern in childhood acute nonlymphocytic leukemia (ANLL)

1982 • 101 citations

MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13.

1993 • 96 citations

Therapy-Related Acute Nonlymphocytic Leukemia with Monocytic Features and Rearrangement of Chromosome 11q

1989 • 93 citations

Detection of four different 11q23 chromosomal abnormalities by multiplex-PCR and fluorescence-based automatic DNA-fragment analysis.

1995 • 85 citations

The der(11)-encoded MLL/AF-4 fusion transcript is consistently detected in t(4;11)(q21;q23)-containing acute lymphoblastic leukemia

1994 • 84 citations

Chromosome pattern in childhood acute nonlymphocytic leukemia (ANLL)

1982 • 83 citations

Prevalence and clinical correlations of MLL gene rearrangements in AML- M4/5

1994 • 78 citations

The RCK gene associated with t(11;14) translocation is distinct from the MLL/ALL-1 gene with t(4;11) and t(11;19) translocations.

1992 • 75 citations

Acute lymphoblastic leukemias with deletion of 11q23 or a novel inversion (11)(p13q23) lack MLL gene rearrangements and have favorable clinical features

1995 • 74 citations

Acute leukemias associated with the 4;11 chromosome translocation have rearranged immunoglobulin heavy chain genes

1985 • 74 citations

The der(II) chromosome contains the critical breakpoint junction in the 4;11, 9;11, and 11;19 translocations in acute leukemia

1992 • 57 citations

Genetic Control of the Spatial Pattern of Selector Gene Expression in Drosophila

1985 • 54 citations

The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute leukemia

1993 • 49 citations

Structure and expression of the human trithorax-like gene 1 involved in acute leukemias.

1993 • 45 citations

Breakpoint clustering in t(4;11)(q21;q23) acute leukemia

1991 • 43 citations

Heterogeneity in MLL/AF-4 fusion messenger RNA detected by the polymerase chain reaction in t(4;11) acute leukemia.

1993 • 38 citations

The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute leukemia

1993 • 36 citations

Molecular analysis of MLL-1/AF4 recombination in infant acute lymphoblastic leukemia.

1994 • 34 citations

Southern blot analysis of ALL-1 rearrangements at chromosome 11q23 in acute leukemia.

1993 • 31 citations

Childhood acute leukemia with t(11;19) (q23;p13).

1991 • 25 citations

Detection of MLL gene rearrangements in adult acute lymphoblastic leukemia. A Cancer and Leukemia Group B study.

1994 • 19 citations

DNA rearrangements and altered transcripts of the MLL gene in a human T‐all cell line karpas 45 with a t(X;II) (q13;q23) translocation

1994 • 16 citations