Biotechnology of β-adrenergic receptors

A novel multigene family may encode odorant receptors: A molecular basis for odor recognition

1991 • 4,793 citations

Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy

1990 • 2,969 citations

A STUDY OF THE ADRENOTROPIC RECEPTORS

1948 • 2,856 citations

Three-dimensional model of purple membrane obtained by electron microscopy

1975 • 2,259 citations

Differentiation of Receptor Systems activated by Sympathomimetic Amines

1967 • 2,054 citations

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

1986 • 1,264 citations

Sequence and expression of a metabotropic glutamate receptor

1991 • 1,200 citations

β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function

1990 • 1,162 citations

Molecular Characterization of the Human β ₃ -Adrenergic Receptor

1989 • 1,071 citations

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments.

1986 • 781 citations

Chimeric α ₂ -,β ₂ -Adrenergic Receptors: Delineation of Domains Involved in Effector Coupling and Ligand Binding Specificity

1988 • 766 citations

Adenylyl Cyclase Amino Acid Sequence: Possible Channel- or Transporter-Like Structure

1989 • 745 citations

Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs

1984 • 724 citations

cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.

1987 • 687 citations

Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins).

1988 • 674 citations

Palmitoylation of the human β2-adrenergic receptor

1989 • 599 citations

The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptor

1988 • 594 citations

Cloning of the cDNA for the human beta 1-adrenergic receptor.

1987 • 577 citations

Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function.

1988 • 533 citations

Site of G Protein Binding to Rhodopsin Mapped with Synthetic Peptides from the α Subunit

1988 • 491 citations

Differentiation of receptors responsive to isoproterenol

1967 • 484 citations

β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family

1989 • 451 citations

Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization

1989 • 415 citations

Identification of residues required for ligand binding to the beta-adrenergic receptor.

1987 • 398 citations

Beta 1- and beta 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium.

1989 • 370 citations

Autoantibodies against beta-adrenoceptors in human idiopathic dilated cardiomyopathy.

1989 • 337 citations

Rapid β-Adrenergic Modulation of Cardiac Calcium Channel Currents by a Fast G Protein Pathway

1989 • 307 citations

Hormone-Sensitive Lipase: Sequence, Expression, and Chromosomal Localization to 19 cent-q13.3

1988 • 305 citations

Structure of the Adrenergic and Related Receptors

1989 • 300 citations

Role of phosphorylation in desensitization of the β-adrenoceptor

1990 • 300 citations

Reconstitutively active G protein-coupled receptors purified from baculovirus-infected insect cells.

1991 • 283 citations

The stimulatory G protein of adenylyl cyclase, Gs, also stimulates dihydropyridine-sensitive Ca2+ channels. Evidence for direct regulation independent of phosphorylation by cAMP-dependent protein kinase or stimulation by a dihydropyridine agonist.

1988 • 273 citations

Down-regulation of beta-adrenergic receptors: agonist-induced reduction in receptor mRNA levels.

1988 • 268 citations

Agonist-induced Destabilization of β-Adrenergic Receptor mRNA

1989 • 267 citations

Beta-adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids.

1988 • 261 citations

Mapping of a functional autoimmune epitope on the beta 1-adrenergic receptor in patients with idiopathic dilated cardiomyopathy.

1990 • 260 citations

Mutations that uncouple the beta-adrenergic receptor from Gs and increase agonist affinity.

1987 • 259 citations

From Epinephrine to Cyclic AMP

1988 • 255 citations

The avian beta-adrenergic receptor: primary structure and membrane topology.

1986 • 252 citations

Structure/function relationship of proteins belonging to the family of receptors coupled to GTP‐binding proteins

1991 • 241 citations

Purification and characterization of the beta-adrenergic receptor kinase.

1987 • 241 citations

CYCLIC AMP AND OTHER SIGNALS CONTROLLING CELL DEVELOPMENT AND DIFFERENTIATION IN DICTYOSTELIUM

1987 • 240 citations

Splice Variants of the α Subunit of the G Protein G _s Activate Both Adenylyl Cyclase and Calcium Channels

1989 • 225 citations

Control of Yeast Mating Signal Transduction by a Mammalian β ₂ -adrenergic Receptor and G _s α Subunit

1990 • 224 citations

Allele-specific activation of genetically engineered receptors.

1991 • 223 citations

Distinct sequence elements control the specificity of G protein activation by muscarinic acetylcholine receptor subtypes.

1990 • 192 citations

Autoantibodies to β₂-Adrenergic Receptors: a Possible Cause of Adrenergic Hyporesponsiveness in Allergic Rhinitis and Asthma

1980 • 190 citations

Structure of the gene for human beta 2-adrenergic receptor: expression and promoter characterization.

1987 • 173 citations

Anti-alprenolol anti-idiotypic antibodies bind to beta-adrenergic receptors and modulate catecholamine-sensitive adenylate cyclase.

1980 • 173 citations

The rat lipolytic β-adrenoceptor: Studies using novel β-adrenoceptor agonists

1984 • 158 citations

Affinity chromatography of the beta-adrenergic receptor.

1979 • 156 citations

Internalization of beta-adrenergic receptor in A431 cells involves non-coated vesicles.

1989 • 155 citations

Protein transport to the vacuole and receptor-mediated endocytosis by clathrin heavy chain-deficient yeast.

1988 • 153 citations

Agonist and antagonist characterization of a putative adrenoceptor with distinct pharmacological properties from the α‐ and β‐subtypes

1988 • 152 citations

Is the adipocyte β-adrenoceptor a prototype for the recently cloned atypical ‘β3-adrenoceptor?’

1990 • 147 citations

Structure-Function Analysis of the -Adrenergic Receptor

1988 • 145 citations

The carboxyl terminus of the hamster β-adrenergic receptor expressed in mouse L cells is not required for receptor sequestration

1987 • 142 citations

A Single Amino Acid Substitution in the β-Adrenergic Receptor Promotes Partial Agonist Activity from Antagonists

1989 • 134 citations

Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process.

1991 • 131 citations

Site-directed mutagenesis of human beta-adrenergic receptors: substitution of aspartic acid-130 by asparagine produces a receptor with high-affinity agonist binding that is uncoupled from adenylate cyclase.

1988 • 131 citations

Hormones, thermogenesis, and obesity

1989 • 128 citations

Identification and sequence of a binding site peptide of the .beta.2-adrenergic receptor

1988 • 128 citations

Site-directed Anti-peptide Antibodies Define the Topography of the β-Adrenergic Receptor

1989 • 127 citations

Functional expression of the human serotonin 5-HT1A receptor in Escherichia coli. Ligand binding properties and interaction with recombinant G protein alpha-subunits.

1992 • 122 citations

The catecholamine binding site of the beta-adrenergic receptor is formed by juxtaposed membrane-spanning domains.

1988 • 121 citations

Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors.

1989 • 117 citations

Catalytic unit of adenlyate cyclase: purification and identification by affinity crosslinking.

1985 • 115 citations

Atypical beta-adrenergic receptor in 3T3-F442A adipocytes. Pharmacological and molecular relationship with the human beta 3-adrenergic receptor.

1991 • 115 citations

Mammalian beta-adrenergic receptors. Distinct glycoprotein populations containing high mannose or complex type carbohydrate chains.

1984 • 115 citations

Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor.

1990 • 109 citations

Isolation of adenylate cyclase-free, beta-adrenergic receptor from turkey erythrocyte membranes by affinity chromatography.

1977 • 104 citations

An antiidiotypic antibody that recognizes the beta-adrenergic receptor.

1982 • 104 citations

Neue broncholytisch hochwirksame Körper der Adrenalinreihe

1940 • 103 citations

Evidence for essential disulfide bonds in beta1-adrenergic receptors of turkey erythrocyte membranes. Inactivation by dithiothreitol.

1979 • 101 citations

Reconstitution of beta 1-adrenoceptor-dependent adenylate cyclase from purified components.

1986 • 97 citations

Inhibition of magnesium uptake by beta-adrenergic agonists and prostaglandin E1 is not mediated by cyclic AMP.

1980 • 94 citations

Differential regulation of beta 1- and beta 2-adrenergic receptor protein and mRNA levels by glucocorticoids during 3T3-F442A adipose differentiation.

1990 • 92 citations

Agonist Regulation of β-Adrenergic Receptor mRNA

1989 • 89 citations

An investigation of the β-adrenoceptor that mediates metabolic responses to the novel agonist BRL28410 in rat soleus muscle

1988 • 84 citations

Down-regulation of β-adrenergic receptor : agonist-induced reduction in mRNA levels

1988 • 82 citations

Receptor-regulated G proteins

1986 • 82 citations

Redistribution of muscarinic acetylcholine receptors on human fibroblasts induced by regulatory ligands

1987 • 81 citations

Monoclonal antibodies to beta-adrenergic receptors: use in purification and molecular characterization of beta receptors.

1980 • 77 citations

125I-labeled p-azidobenzylcarazolol, a photoaffinity label for the beta-adrenergic receptor. Characterization of the ligand and photoaffinity labeling of beta 1- and beta 2-adrenergic receptors.

1982 • 76 citations

Selective binding of ligands to beta 1, beta 2 or chimeric beta 1/beta 2-adrenergic receptors involves multiple subsites.

1990 • 76 citations

Human beta 2-adrenergic receptors expressed in Escherichia coli membranes retain their pharmacological properties.

1988 • 69 citations

Expression of two human beta-adrenergic receptors in Escherichia coli: functional interaction with two forms of the stimulatory G protein.

1991 • 69 citations

Photoaffinity labeling of the beta-adrenergic receptor with azide derivatives of iodoccyanopindolol.

1982 • 68 citations

Atypical characteristics of the beta-adrenoceptor mediating cyclic AMP generation and lipolysis in the rat adipocyte.

1985 • 65 citations

Structural basis for functional diversity of β1-, β2- and β3-adrenergic receptors

1991 • 62 citations

High-efficiency expression of mammalian β-adrenergic receptors in baculovirus-infected insect cells

1989 • 62 citations

Biophysical and genetic analysis of the ligand-binding site of the β-adrenoceptor

1991 • 60 citations

Expression of Human β1 and β2 Adrenergic Receptors in E. Coli As a New Tool for Ligand Screening

1989 • 58 citations

β-adrenoceptor studies. 6. Further investigations on the hybrid nature of the rat adipocyte β-adrenoceptor

1980 • 55 citations

beta-Adrenergic agonist activity of a monoclonal anti-idiotypic antibody.

1985 • 53 citations

Localization and characterization of three different β‐adrenergic receptors expressed in Escherichia coli

1990 • 48 citations

The alpha-2 Adrenergic Receptors

1988 • 47 citations

Antigenic analysis of the second extra-cellular loop of the human beta-adrenergic receptors.

1989 • 47 citations

Inactivation of beta-adrenergic receptors by N-ethylmaleimide: permissive role of beta-adrenergic agents in relation to adenylate cyclase activation.

1980 • 46 citations

Antibodies raised against β-adrenergic receptors stimulate adenylate cyclase

1981 • 44 citations

The alpha-1 Adrenergic Receptors

1987 • 42 citations

Affinity Chromatography of the β‐Adrenergic Receptor from Turkey Erythrocytes

1979 • 40 citations

Mutational analysis of ligand binding activity of beta 2 adrenergic receptor expressed in Escherichia coli.

1990 • 40 citations

A response to isoprenaline unrelated to α‐and β‐adrenoceptor agonism

1987 • 39 citations

The oligosaccharide moiety of the .beta.1-adrenergic receptor from turkey erythrocytes has a biantennary, N-acetyllactosamine-containing structure

1985 • 38 citations

Cyclical antiidiotypic response to anti-hormone antibodies due to neutralization by autologous anti-antiidiotype antibodies that bind hormone.

1983 • 37 citations

Sodium regulation of agonist and antagonist binding to ?-adrenoceptors in intact and Ns-deficient membranes

1986 • 32 citations

The β2-adrenergic receptors of human epidermoid carcinoma cells bear two different types of oligosaccharides which influence expression on the cell surface

1988 • 31 citations

Monoclonal antibodies directed against the human A431 β‐adrenergic receptor recognize two major polypeptide chains

1987 • 29 citations

Responses to norepinephrine resistant to inhibition by alpha and beta adrenoceptor antagonists.

1986 • 28 citations

Interaction between beta-adrenergic receptors and guanine nucleotide sites in turkey erythrocyte membranes.

1980 • 28 citations

Antipeptide antibodies directed against cytoplasmic rhodopsin sequences recognize the beta-adrenergic receptor.

1987 • 26 citations

Continuous high density expression of human beta 2-adrenergic receptors in a mouse cell line previously lacking beta-receptors.

1987 • 26 citations

Alloimmune IgG binds and modulates cardiac beta-adrenoceptor activity.

1984 • 19 citations

[13] Interaction of anti-idiotypic antibodies with membrane receptors: Practical considerations

1989 • 18 citations

G protein diversity and the regulation of signaling pathways.

1990 • 12 citations

Functional Domains in the -Adrenergic Receptor

1988 • 10 citations

[18] Anti-idiotypic antibodies that interact with β-adrenergic catecholamine receptor

1989 • 10 citations

Anti-idiotypic antibodies against hormone and neurotransmitter receptors

1991 • 9 citations

A Monoclonal Antibody Directed Against the β₁-Adrenergic Receptor from Turkey Erythrocyte Membranes

1989 • 8 citations

Receptor-based assays

1991 • 8 citations

Antireceptor Antibodies

1985 • 5 citations

Structure et fonction des recepteurs beta-adrenergiques humains

1990 • 1 citations

Purification of β-Adrenergic Receptors

1990 • 1 citations

Deleted Work

1955 • 0 citations