Expression of two human beta-adrenergic receptors in Escherichia coli: functional interaction with two forms of the stimulatory G protein.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid, sensitive, and specific method for the determination of protein in dilute solution

1973 • 2,518 citations

Diversity of G Proteins in Signal Transduction

1991 • 1,990 citations

Molecular Characterization of the Human β ₃ -Adrenergic Receptor

1989 • 1,071 citations

Biochemical Properties of Hormone-Sensitive Adenylate Cyclase

1980 • 1,016 citations

cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.

1987 • 687 citations

Cloning of the cDNA for the human beta 1-adrenergic receptor.

1987 • 577 citations

G proteins control diverse pathways of transmembrane signaling ¹

1989 • 399 citations

Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins.

1986 • 380 citations

Signal sorting and amplification through G protein-coupled receptors

1989 • 338 citations

Resolution of some components of adenylate cyclase necessary for catalytic activity.

1977 • 283 citations

Expression of Gsα in Escherichia coli

1989 • 262 citations

Splice Variants of the α Subunit of the G Protein G _s Activate Both Adenylyl Cyclase and Calcium Channels

1989 • 225 citations

Purification and characterization of Go alpha and three types of Gi alpha after expression in Escherichia coli.

1990 • 208 citations

Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles.

1986 • 199 citations

Mutations of Gs α Designed to Alter the Reactivity of the Protein with Bacterial Toxins

1989 • 177 citations

Structure of the gene for human beta 2-adrenergic receptor: expression and promoter characterization.

1987 • 173 citations

Specificity of receptor-G protein interactions. Discrimination of Gi subtypes by the D2 dopamine receptor in a reconstituted system.

1990 • 173 citations

Reconstitution of catecholamine-sensitive adenylate cyclase. Reconstitution of the uncoupled variant of the S40 lymphoma cell.

1979 • 171 citations

Reciprocal modulation of agonist and antagonist binding to muscarinic cholinergic receptor by guanine nucleotide.

1982 • 132 citations

Expression of three human β‐adrenergic‐receptor subtypes in transfected chinese hamster ovary cells

1991 • 117 citations

Quantitative analysis of the selectivity of radioligands for subtypes of beta adrenergic receptors.

1986 • 95 citations

The hydrophobic tryptic core of the beta-adrenergic receptor retains Gs regulatory activity in response to agonists and thiols.

1987 • 87 citations

Interactions of purified bovine brain A1-adenosine receptors with G-proteins. Reciprocal modulation of agonist and antagonist binding

1991 • 72 citations

Model Testing in Radioligand/Receptor Interaction by Monte Carlo Simulation

1983 • 49 citations

Localization and characterization of three different β‐adrenergic receptors expressed in Escherichia coli

1990 • 48 citations

Differences in the GTP-regulation of membrane-bound and solubilized A1-adenosine receptors

1989 • 21 citations

Evidence for two specific affinity states of 3H-antagonist binding to cardiac beta-adrenergic receptors and influence of Gpp(NH)p.

1985 • 10 citations