The amplified H circle of methotrexate-resistant leishmania tarentolae contains a novel P-glycoprotein gene.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

Selective extraction of polyoma DNA from infected mouse cell cultures

1967 • 5,357 citations

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

Therapy of CF-Patients with Amitriptyline and Placebo - a Randomised, Double-Blind, Placebo-Controlled Phase IIb Multicenter, Cohort-Study

2013 • 2,504 citations

Signal sequences

1985 • 2,179 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

The multidrug transporter, a double-edged sword.

1988 • 763 citations

A family of related ATP-binding subunits coupled to many distinct biological processes in bacteria

1986 • 753 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

[20] Isolation of RNA using guanidinium salts

1987 • 614 citations

The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein

1989 • 604 citations

Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum

1989 • 570 citations

Amplification of a Gene Related to Mammalian mdr Genes in Drug-Resistant Plasmodium falciparum

1989 • 439 citations

Sequence of mdr3 cDNA encoding a human P-glycoprotein

1988 • 292 citations

Cloning and characterization of a second member of the mouse mdr gene family.

1988 • 268 citations

Unstable DNA amplifications in methotrexate resistant Leishmania consist of extrachromosomal circles which relocalize during stabilization

1984 • 260 citations

Activation of trypanosome surface glycoprotein genes involves a duplication-transposition leading to an altered 3′ end

1981 • 258 citations

The brown protein of Drosophila melanogaster is similar to the white protein and to components of active transport complexes.

1988 • 224 citations

Bovine opsin has more than one signal sequence

1985 • 186 citations

Multidrug Resistance

1989 • 166 citations

The H circles of Leishmania tarentolae are a unique amplifiable system of oligomeric DNAs associated with drug resistance.

1988 • 125 citations

Multiple Drug Resistance and Conservative Amplification of the H Region in Leishmania major

1989 • 120 citations

Methotrexate-resistant Leishmania donovani genetically deficient in the folate-methotrexate transporter.

1988 • 96 citations

Cloning and nucleotide sequence of the chlD locus

1987 • 79 citations

Reductions in methotrexate and folate influx in methotrexate-resistant lines of Leishmania major are independent of R or H region amplification.

1987 • 74 citations

Transcription of kinetoplast DNA in Trypanosoma brucei bloodstream and culture forms

1981 • 73 citations

Extrachromosomal elements in the lower eukaryote Leishmania.

1988 • 68 citations

fhuC and fhuD genes for iron (III)-ferrichrome transport into Escherichia coli K-12

1987 • 63 citations

Amplified DNAs in laboratory stocks of Leishmania tarentolae: extrachromosomal circles structurally and functionally similar to the inverted-H-region amplification of methotrexate-resistant Leishmania major.

1988 • 56 citations

The Brown Protein of Drosophila melanogaster is Similar to the White Protein and to Components of Active Transport Complexes

1988 • 49 citations

Cloning and Characterization of a Second Member of the Mouse mdr Gene Family

1988 • 45 citations

H DNA amplification in Leishmania resistant to both arsenite and methotrexate

1989 • 39 citations

Wild-type and Drug-resistant Leishmania major Hydrolyze Methotrexate to N-10-Methyl-4-deoxy-4-aminopteroate without Accumulation of Methotrexate Polyglutamates

1989 • 32 citations

Folylpolyglutamates in Leishmania major

1987 • 14 citations

Amplified DNAs in Laboratory Stocks of Leishmania tarentolae: Extrachromosomal Circles Structurally and Functionally Similar to the Inverted-H-Region Amplification of Methotrexate-Resistant Leishmania major

1988 • 13 citations