Amplified DNAs in laboratory stocks of Leishmania tarentolae: extrachromosomal circles structurally and functionally similar to the inverted-H-region amplification of methotrexate-resistant Leishmania major.

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1984 • 4,899 citations

Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis

1984 • 2,847 citations

Advanced bacterial genetics

1980 • 2,388 citations

Gene amplification in cultured animal cells

1984 • 639 citations

Chemical Changes Induced in DNA by Ionizing Radiation

1985 • 570 citations

Biology of the Kinetoplastida

1977 • 500 citations

Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines.

1985 • 441 citations

Genetic and biochemical characterization of multidrug resistance

1985 • 405 citations

Antigenic variation in trypanosoma brucei analyzed by electrophoretic separation of chromosome-sized DNA molecules

1984 • 368 citations

Gene amplification in cultured cells.

1988 • 289 citations

The Mitochondrial Genome of Kinetoplastid Protozoa: Genomic Organization, Transcription, Replication, and Evolution

1987 • 288 citations

Unstable DNA amplifications in methotrexate resistant Leishmania consist of extrachromosomal circles which relocalize during stabilization

1984 • 260 citations

Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications.

1986 • 242 citations

Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica.

1983 • 239 citations

Double minute chromosomes can be produced from precursors derived from a chromosomal deletion.

1988 • 236 citations

GENE AMPLIFICATION IN LEISHMANIA

1991 • 217 citations

Editing of kinetoplastid mitochondrial mRNAs by uridine addition and deletion generates conserved amino acid sequences and AUG initiation codons

1988 • 213 citations

DNA Sequence Amplification in Mammalian Cells

1984 • 181 citations

Characterization of the ‘unusual’ mobility of large circular DNAs in pulsed field-gradient electroplioresis

1988 • 167 citations

Primary structure of the gene encoding the bifunctional dihydrofolate reductase-thymidylate synthase of Leishmania major.

1986 • 165 citations

Large inverted duplications are associated with gene amplification

1986 • 147 citations

Characterization of an Episome Produced in Hamster Cells that Amplify a Transfected CAD Gene at High Frequency: Functional Evidence for a Mammalian Replication Origin

1987 • 137 citations

Chromosomes of kinetoplastida.

1984 • 126 citations

Stable Amplified DNA in Drug-Resistant Leishmania Exists as Extrachromosomal Circles

1986 • 124 citations

DNA amplification in drug resistant cells and in tumours.

1986 • 115 citations

Sequence arrangement of the 16S and 26S rRNA genes in the pathogenic haemoflagellate Leishmania donovani

1978 • 114 citations

Double Minute Chromosomes Can Be Produced from Precursors Derived from a Chromosomal Deletion

1988 • 112 citations

Evolution of the genus Leishmania as revealed by comparisons of nuclear DNA restriction fragment patterns.

1987 • 108 citations

On the possibility of metabolic control of replicon "misfiring": relationship to emergence of malignant phenotypes in mammalian cell lineages.

1981 • 104 citations

Isolation of the amplified dihydrofolate reductase domain from methotrexate-resistant Chinese hamster ovary cells.

1987 • 97 citations

Bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania tropica: sequence homology with the corresponding monofunctional proteins.

1986 • 92 citations

Novel DNA rearrangements are associated with dihydrofolate reductase gene amplification.

1984 • 90 citations

Novel submicroscopic extrachromosomal elements containing amplified genes in human cells

1987 • 85 citations

Characterization of an episome produced in hamster cells that amplify a transfected CAD gene at high frequency: functional evidence for a mammalian replication origin.

1987 • 80 citations

Sexual processes in the kinetoplastida

1983 • 76 citations

Reductions in methotrexate and folate influx in methotrexate-resistant lines of Leishmania major are independent of R or H region amplification.

1987 • 74 citations

Biochemistry and regulation of folate and methotrexate transport in Leishmania major.

1987 • 73 citations

Plasmid migration using orthogonal-field-alternation gel electrophoresis

1987 • 71 citations

Genetic analysis of adenine metabolism in Leishmania donovani promastigotes. Evidence for diploidy at the adenine phosphoribosyltransferase locus.

1984 • 69 citations

DNA amplification in tunicamycin-resistant Leishmania mexicana. Multicopies of a single 63-kilobase supercoiled molecule and their expression.

1988 • 65 citations

Tunicamycin-resistant Leishmania mexicana amazonensis: expression of virulence associated with an increased activity of N-acetylglucosaminyltransferase and amplification of its presumptive gene.

1987 • 64 citations

Comparison of several lizard Leishmania species and strains in terms of kinetoplast minicircle and maxicircle DNA sequences, nuclear chromosomes, and membrane lipids

1988 • 55 citations

Nucleic acid hybridization for measurement of effects of antiviral compounds on human cytomegalovirus DNA replication

1983 • 46 citations

Selection and properties of Leishmania tropica resistant to 10-propargyl-5,8-dideazafolate, an inhibitor of thymidylate synthetase

1985 • 44 citations

Gene Amplification In Leishmania

1991 • 42 citations

The identity ofLeishmania tarentolaeWenyon 1921

1985 • 41 citations

Impaired drug uptake in methotrexate resistant Crithidia fasciculata without changes in dihydrofolate reductase activity or gene amplification

1986 • 34 citations

Isolation of the Amplified Dihydrofolate Reductase Domain from Methotrexate-Resistant Chinese Hamster Ovary Cells

1987 • 34 citations

Introduction of plasmid DNA into the trypanosomatid protozoan Crithidia fasciculata.

1986 • 9 citations

Deleted Work

1955 • 0 citations