Induced apoptosis in the prevention of colorectal cancer by non-steroidal anti-inflammatory drugs.

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

1994 • 2,553 citations

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

1996 • 2,387 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells

1998 • 2,282 citations

Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential

1997 • 1,411 citations

Expression of cyclooxygenase-1 and -2 in human colorectal cancer.

1995 • 1,135 citations

Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells.

1998 • 1,130 citations

Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis.

1998 • 933 citations

Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer.

1995 • 837 citations

Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2.

1997 • 734 citations

Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway

1996 • 613 citations

Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis

1998 • 593 citations

Nonsteroidal anti-inflammatory drugs and gastroenteropathy: The second hundred years

1997 • 569 citations

Inhibition of apoptosis during development of colorectal cancer.

1995 • 548 citations

Apoptosis and APC in colorectal tumorigenesis.

1996 • 491 citations

Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect.

1996 • 462 citations

Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis.

1995 • 433 citations

Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis.

1996 • 421 citations

Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells.

1995 • 420 citations

Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression.

1997 • 369 citations

Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels.

1997 • 362 citations

Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction.

1997 • 352 citations

Nonsteroidal Antiinflammatory Drugs Inhibit the Proliferation of Colon Adenocarcinoma Cells: Effects on Cell Cycle and Apoptosis

1996 • 343 citations

Patients with adenomatous polyps and carcinomas have increased colonic mucosal prostaglandin E2.

1994 • 269 citations

The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis

1995 • 253 citations

Sulfone metabolite of sulindac inhibits mammary carcinogenesis.

1997 • 211 citations

Selected eicosanoids increase the proliferation rate of human colon carcinoma cell lines and mouse colonocytes in vivo

1995 • 196 citations

A selective cyclooxygenase 2 inhibitor suppresses the growth of H-ras-transformed rat intestinal epithelial cells

1997 • 185 citations

Differential growth inhibition by the aspirin metabolite salicylate in human colorectal tumor cell lines: enhanced apoptosis in carcinoma and in vitro-transformed adenoma relative to adenoma relative to adenoma cell lines.

1996 • 173 citations

The anti-proliferative effect of sulindac and sulindac sulfide on HT-29 colon cancer cells: alterations in tumor suppressor and cell cycle-regulatory proteins.

1996 • 151 citations

Effect of aspirin on induction of apoptosis in HT-29 human colon adenocarcinoma cells

1998 • 134 citations

NSAID USE AND DECREASED RISK OF GASTROINTESTINAL CANCERS

1996 • 124 citations

Apoptosis Induced by NS‐398, a Selective Cyclooxygenase‐2 Inhibitor, in Human Colorectal Cancer Cell Lines

1997 • 109 citations

R-flurbiprofen chemoprevention and treatment of intestinal adenomas in the APC(Min)/+ mouse model: implications for prophylaxis and treatment of colon cancer.

1997 • 97 citations

P53 and angiogenesis

1996 • 78 citations

COX-2 inhibitors for colorectal cancer

1998 • 71 citations

A K-ras oncogene increases resistance to sulindac-induced apoptosis in rat enterocytes

1997 • 70 citations

Suppression of azoxymethane-induced aberrant crypt foci in rat colon by nimesulide, a selective inhibitor of cyclooxygenase 2

1996 • 66 citations

Effect of aspirin on cell proliferation and differentiation of colon adenocarcinoma Caco-2 cells

1997 • 63 citations

Modulation of azoxymethane-induced mutational activation of ras protooncogenese by chemopreventive agents in colon carcinogenesis

1994 • 61 citations

NSAID-INDUCED POLYP REGRESSION IN FAMILIAL ADENOMATOUS POLYPOSIS PATIENTS

1996 • 40 citations

c-K-ras transformed rat enterocytes (R1) are more sensitive than normal enterocytes (IEC18) to growth inhibition and appptosis-induced by sulindac sulfone and nimesulid

1998 • 3 citations

Change in apoptosis in patients treated with sulindac

1998 • 2 citations

Effect of sulindac sulfone on proliferation, apoptosis, and polyps in a clinical trial in familial adenomatous polyposis (FAP) with rectal polyps

1998 • 2 citations

Cellular and molecular effects of a cyclo-oxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug on colorectal adenoma and carcinoma cell lines

1998 • 1 citations