NSAID-INDUCED POLYP REGRESSION IN FAMILIAL ADENOMATOUS POLYPOSIS PATIENTS

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

1994 • 2,553 citations

Identification of FAP Locus Genes from Chromosome 5q21

1991 • 2,358 citations

APC mutations occur early during colorectal tumorigenesis

1992 • 1,901 citations

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

Treatment of Colonic and Rectal Adenomas with Sulindac in Familial Adenomatous Polyposis

1993 • 1,739 citations

A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse

1990 • 1,550 citations

AHFS Drug Information

1994 • 922 citations

Nonsteroidal Antiinflammatory Drugs — Differences and Similarities

1991 • 756 citations

Sulindac causes regression of rectal polyps in familial adenomatous polyposis

1991 • 736 citations

Multiple cutaneous and subcutaneous lesions occurring simultaneously with hereditary polyposis and osteomatosis.

1953 • 703 citations

Sulindac for polyposis of the colon

1983 • 521 citations

Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis

1993 • 494 citations

Sulindac for polyposis of the colon

1989 • 418 citations

Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats

1993 • 353 citations

Abnormal pattern of cell proliferation in the entire colonic mucosa of patients with colon adenoma or cancer

1987 • 311 citations

Dose-related inhibition of colon carcinogenesis by dietary piroxicam, a nonsteroidal antiinflammatory drug, during different stages of rat colon tumor development.

1987 • 305 citations

The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system.

1992 • 303 citations

Familial Polyposis Coli. Family Studies, Histopathology, Differential Diagnosis, and Results of Treatment.

1975 • 300 citations

Phase 1 and phase 2 proliferative lesions of colonic epithelial cells in diseases leading to colonic cancer

1974 • 259 citations

The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis

1995 • 253 citations

Inhibition of development of methylnitrosourea-induced rat colon tumors by indomethacin treatment.

1981 • 229 citations

Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal antiinflammatory drug with D,L-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor, in diet.

1990 • 224 citations

Effects of Long-term Sulindac Therapy on Colonic Polyposis

1991 • 202 citations

Chemical and Biological Studies on Indomethacin, Sulindac and their Analogs

1977 • 196 citations

Chemoprevention of colon carcinogenesis by dietary administration of piroxicam, alpha-difluoromethylornithine, 16 alpha-fluoro-5-androsten-17-one, and ellagic acid individually and in combination.

1991 • 191 citations

Familial Polyposis Coli. Family Studies, Histopathology, Differential Diagnosis, and Results of Treatment

1976 • 177 citations

Effect of Indomethacin on Intestinal Tumors Induced in Rats by the Acetate Derivative of Dimethylnitrosamine

1981 • 162 citations

A protective effect of sulindac against chemically‐induced primary colonic tumours in mice

1988 • 140 citations

Nonsteroidal Anti-Inflammatory Agents

1979 • 139 citations

Identification of the biologically active form of sulindac.

1977 • 136 citations

Indomethacin treatment of rats with dimethylhydrazine-induced intestinal tumors.

1980 • 132 citations

Rectal proliferation and polyp occurrence in patients with familial adenomatous polyposis after sulindac treatment

1994 • 130 citations

Adenocarcinoma in the rectal segment in familial polyposis coli is not prevented by sulindac therapy

1994 • 127 citations

Piroxicam and other cyclooxygenase inhibitors: Potential for cancer chemoprevention

1992 • 122 citations

Inhibition of Intestinal Carcinogenesis in Rats: Effect of Difluoromethylornithine With Piroxicam or Fish Oil<xref ref-type="fn" rid="FN2">2</xref>

1986 • 113 citations

The suppressive effect of piroxicam on autochthonous intestinal tumors in the rat

1983 • 106 citations

The NSAID sulindac reverses rectal adenomas in colectomized patients with familial adenomatous polyposis: clinical results of a dose-finding study on rectal sulindac administration

1993 • 99 citations

Antitumor activity of indomethacin on methylazoxymethanol-induced large bowel tumors in rats.

1980 • 97 citations

Inhibition of initiation and promotion by N-methylnitrosourea-induced colon carcinogenesis in rats by non-steroid anti-inflammatory agent indomethacin

1983 • 94 citations

Effect of piroxicam on primary intestinal tumors induced in rats by N-methylnitrosourea

1984 • 90 citations

Prolonged Antitumor Effect of Indomethacin on Autochthonous Intestinal Tumors in Rats<xref ref-type="fn" rid="FN2">2</xref>

1983 • 89 citations

Influence of various prostaglandin synthesis inhibitors on DMH-induced rat colon cancer

1984 • 78 citations

Physiologic disposition and metabolic fate of a new anti-inflammatory agent, cis-5-fluro-2-methyl-1-(p-(methylsulfinyl)-benzylidenyl)-indene-3-acetic acid in the rat, dog, rhesus monkey, and man.

1973 • 77 citations

NSAID effect on sporadic colon polyps.

1993 • 74 citations

Progress in applied chemoprevention research.

1990 • 56 citations

Prevention and treatment of primary intestinal tumors in rats by piroxicam.

1989 • 44 citations

Growth inhibition of transplantable murine colon adenocarcinoma 38 by indomethacin

1983 • 43 citations

Medicine and the Law

1982 • 42 citations

Reduction of carcinogenicity of N-nitrosomethylurea by indomethacin and failure of resuming effect of prostaglandin E2 (PGE2) against indomethacin

1984 • 40 citations

Inhibition of development of methylnitrosourea-induced rat colonic tumors by peroral administration of indomethacin.

1982 • 40 citations

The effect of sulindac on colonic tumour formation in dimethylhydrazine-treated mice.

1990 • 32 citations

Piroxicam inhibits the growth of an adenocarcinoma isograft in Fischer rats

1988 • 27 citations

[Necrotizing vasculitis and villous atrophy of the small intestine].

1986 • 14 citations

Reduction of acetoxymethyl-methylnitrosamine-induced large bowel cancer in rats by indomethacin.

1984 • 12 citations

[Sulindac in familial adenomatous polyposis coli--preliminary findings of a prospective study].

1994 • 11 citations

NSAIDs inhibit the growth of colon cancer cell lines by a prostaglandin independent pathway

1995 • 6 citations

The sulfone metabolite of sulindac (FGN-1) inhibits rat colonic carcinogenesis but does not inhibit either prostaglandin synthesis or colonic proliferation

1995 • 3 citations

Sulindac has maximal effect on small but not large polyps in the duodenum in patients with familial adenomatous polyposis

1995 • 2 citations

Aspirin and other NSAIDs inhibit the proliferation of colon adenocarcinoma cells: Effects on cell cycle and apoptosis

1995 • 2 citations