Efficient, Repeated Adenovirus-Mediated Gene Transfer in Mice Lacking both Tumor Necrosis Factor Alpha and Lymphotoxin α

Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response.

1996 • 1,167 citations

Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses

1995 • 1,048 citations

The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein

1994 • 1,030 citations

Characterization of tumor necrosis factor-deficient mice

1997 • 792 citations

Immune responses to transgene–encoded proteins limit the stability of gene expression after injection of replication–defective adenovirus vectors

1996 • 640 citations

Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver.

1994 • 627 citations

MHC class I-cestricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses

1994 • 619 citations

Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression.

1995 • 599 citations

Widespread long-term gene transfer to mouse skeletal muscles and heart.

1992 • 586 citations

A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase.

1996 • 572 citations

Characterization of 911: A New Helper Cell Line for the Titration and Propagation of Early Region 1-Deleted Adenoviral Vectors

1996 • 516 citations

Lymphotoxin ?, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface

1993 • 468 citations

Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness.

1995 • 436 citations

The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors

1997 • 409 citations

Adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection

1982 • 395 citations

Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy

1996 • 379 citations

A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia.

1991 • 348 citations

Anti-IL-6 monoclonal antibodies protect against lethal Escherichia coli infection and lethal tumor necrosis factor-alpha challenge in mice.

1990 • 343 citations

Role of early region 3 (E3) in pathogenesis of adenovirus disease.

1989 • 285 citations

Recombinant IL–12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung

1995 • 246 citations

Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: comparisons between immunocompetent and immunodeficient inbred strains.

1995 • 244 citations

Angiostatin gene transfer: Inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest

1998 • 239 citations

Differentiation of follicular dendritic cells and full antibody responses require tumor necrosis factor receptor-1 signaling.

1996 • 217 citations

Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo

1996 • 214 citations

Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ

1997 • 213 citations

Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression

1997 • 208 citations

Forced degradation of Fas inhibits apoptosis in adenovirus-infected cells

1998 • 203 citations

Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-α double-deficient mice

1996 • 201 citations

Lymphotoxin but not tumor necrosis factor functions to maintain splenic architecture and humoral responsiveness in adult mice

1997 • 192 citations

Crucial role of 55-kilodalton TNF receptor in TNF-induced adhesion molecule expression and leukocyte organ infiltration.

1996 • 188 citations

Transient subversion of CD40 ligand function diminishes immune responses to adenovirus vectors in mouse liver and lung tissues

1996 • 185 citations

The 26-kD transmembrane form of tumor necrosis factor alpha on activated CD4+ T cell clones provides a costimulatory signal for human B cell activation.

1993 • 168 citations

The adenovirus E3-10.4K/14.5K complex mediates loss of cell surface Fas (CD95) and resistance to Fas-induced apoptosis

1997 • 165 citations

Long-term gene delivery into the livers of immunocompetent mice with E1/E4-defective adenoviruses

1997 • 160 citations

Membrane tumour necrosis factor-α is involved in the polyclonal B-cell activation induced by HIV-infected human T cells

1993 • 147 citations

Tumor necrosis factor-alpha induces cell type and tissue-specific expression of chemoattractant cytokines in vivo.

1993 • 139 citations

Oral tolerization to adenoviral antigens permits long-term gene expression using recombinant adenoviral vectors.

1997 • 136 citations

Persistent transgene expression in mouse liver following in vivo gene transfer with a ΔE1/ΔE4 adenovirus vector

1997 • 136 citations

Tumor necrosis factor α plays a central role in immune-mediated clearance of adenoviral vectors

1997 • 130 citations

Transient immunosuppression permits successful repetitive intravenous administration of an adenovirus vector.

1996 • 127 citations

Successful expression of human factor IX following repeat administration of adenoviral vector in mice.

1996 • 125 citations

Interaction of the Adenovirus 14.7-kDa Protein with FLICE Inhibits Fas Ligand-induced Apoptosis

1998 • 104 citations

Pulmonary Inflammation Induced by Incomplete or Inactivated Adenoviral Particles

1995 • 103 citations

Macrophage depletion increases the safety, efficacy and persistence of adenovirus-mediated gene transfer in vivo

1997 • 94 citations

Adenovirus-Mediated Gene Transfer of Viral Interleukin-10 Inhibits the Immune Response to Both Alloantigen and Adenoviral Antigen

1997 • 92 citations

Systematic Analysis of Repeated Gene Delivery into Animal Lungs with a Recombinant Adenovirus Vector

1996 • 89 citations

Interaction of recombinant IL-1 and recombinant tumor necrosis factor in the induction of mouse acute phase proteins.

1988 • 88 citations

The constitutive expression of the immunomodulatory gp19k protein in E1-, E3- adenoviral vectors strongly reduces the host cytotoxic T cell response against the vector.

1995 • 85 citations

A dual role for both CD40-ligand and TNF-alpha in controlling human B cell death.

1996 • 80 citations

Adenovirus E3-10.4K/14.5K protein complex inhibits tumor necrosis factor-induced translocation of cytosolic phospholipase A2 to membranes

1997 • 75 citations

The role of human adenovirus early region 3 proteins (gp19K, 10.4K, 14.5K, and 14.7K) in a murine pneumonia model

1996 • 74 citations

Humoral immune response to the capsid components of recombinant adenoviruses: Routes of immunization modulate virus‐induced Ig subclass shifts

1997 • 74 citations

Defective co-stimulation and impaired Th1 development in tumor necrosis factor/lymphotoxin-alpha double-deficient mice infected with Candida albicans

1998 • 72 citations

Enhancement of in vivo immune response by tumor necrosis factor.

1987 • 59 citations

Long-lasting adenovirus transgene expression in mice through neonatal intrathymic tolerance induction without the use of immunosuppression

1997 • 56 citations

Expression of gp19K increases the persistence of transgene expression from an adenovirus vector in the mouse lung and liver

1997 • 56 citations

Mice heterozygous for a deletion of the tumor necrosis factor‐α and lymphotoxin‐α genes: biological importance of a nonlinear response of tumor necrosis factor‐α to gene dosage

1997 • 50 citations

Expression of human α₁‐antitrypsin using a recombinant adenovirus vector

1990 • 50 citations

Polyclonal B cell activation induced by herpesvirus saimiri-transformed human CD4+ T cell clones. Role for membrane TNF-alpha/TNF-alpha receptors and CD2/CD58 interactions.

1994 • 38 citations

Lack of type 2 T cell-independent B cell responses and defect in isotype switching in TNF-lymphotoxin alpha-deficient mice.

1997 • 37 citations

A modified double antibody sandwich enzyme-linked immunosorbent assay for measurement of alpha-1-antitrypsin in biologic fluids

1985 • 34 citations

The adenovirus E3 14.5-kilodalton protein, which is required for down-regulation of the epidermal growth factor receptor and prevention of tumor necrosis factor cytolysis, is an integral membrane protein oriented with its C terminus in the cytoplasm

1992 • 31 citations

Adenovirus proteins that regulate susceptibility to TNF also regulate the activity of PLA2

1994 • 10 citations

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