Long-term gene delivery into the livers of immunocompetent mice with E1/E4-defective adenoviruses

Selective extraction of polyoma DNA from infected mouse cell cultures

1967 • 5,357 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.

1994 • 1,599 citations

Immune responses to transgene–encoded proteins limit the stability of gene expression after injection of replication–defective adenovirus vectors

1996 • 640 citations

MHC class I-cestricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses

1994 • 619 citations

Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression.

1995 • 599 citations

Widespread long-term gene transfer to mouse skeletal muscles and heart.

1992 • 586 citations

A comparison of the biological activities of wild‐type and mutant p53

1993 • 423 citations

Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo.

1996 • 383 citations

Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff

1985 • 383 citations

Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy

1996 • 379 citations

A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia.

1991 • 348 citations

Blockage by Adenovirus E4orf6 of Transcriptional Activation by the p53 Tumor Suppressor

1996 • 315 citations

Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1–deleted adenoviruses

1993 • 303 citations

The Adenovirus E1B-55K Transforming Polypeptide Modulates Transport or Cytoplasmic Stabilization of Viral and Host Cell mRNAs

1986 • 301 citations

In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses.

1994 • 298 citations

Adenovirus DNA replication in vitro.

1979 • 294 citations

Adenovirus gene transfer causes inflammation in the brain

1995 • 283 citations

Redundant control of adenovirus late gene expression by early region 4

1989 • 261 citations

Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: comparisons between immunocompetent and immunodeficient inbred strains.

1995 • 244 citations

Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport.

1985 • 234 citations

Adenovirus early region 4 encodes two gene products with redundant effects in lytic infection

1989 • 225 citations

Adenovirus early region 1B 58,000-dalton tumor antigen is physically associated with an early region 4 25,000-dalton protein in productively infected cells

1984 • 221 citations

Elimination of both E1 and E2 from adenovirus vectors further improves prospects for in vivo human gene therapy

1996 • 200 citations

RNA Methodologies: A Laboratory Guide for Isolation and Characterization

2009 • 185 citations

Adenovirus E4orf4 protein binds to protein phosphatase 2A, and the complex down regulates E1A-enhanced junB transcription

1993 • 168 citations

Oncogenic potential of the adenovirus E4orf6 protein.

1996 • 155 citations

Tissue-Specific Expression in Transgenic Mice of a Fused Gene Containing RSV Terminal Sequences

1986 • 154 citations

Deletion of the E4 region of the genome produces adenovirus DNA concatemers.

1994 • 150 citations

Adenoviral early region 4 is required for efficient viral DNA replication and for late gene expression

1986 • 145 citations

Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa protein

1994 • 143 citations

A cell line that supports the growth of a defective early region 4 deletion mutant of human adenovirus type 2.

1983 • 141 citations

Development of Cell Lines Capable of Complementing E1, E4, and Protein IX Defective Adenovirus Type 5 Mutants

1995 • 131 citations

Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit

1996 • 125 citations

Adenovirus E1B Proteins Are Required for Accumulation of Late Viral mRNA and for Effects on Cellular mRNA Translation and Transport

1985 • 117 citations

Adenovirus E4orf4 protein reduces phosphorylation of c-Fos and E1A proteins while simultaneously reducing the level of AP-1

1992 • 107 citations

The adenovirus DNA-binding protein stimulates the rate of transcription directed by adenovirus and adeno-associated virus promoters

1990 • 104 citations

Adenovirus early region 4 34-kilodalton protein directs the nuclear localization of the early region 1B 55-kilodalton protein in primate cells

1996 • 101 citations

Adenovirus DNA Replication

2003 • 100 citations

Region-specific initiation of mouse mammary tumor virus RNA synthesis by endogenous RNA polymerase II in preparations of cell nuclei.

1983 • 98 citations

NF-IL6, a member of the C/EBP family, regulates E1A-responsive promoters in the absence of E1A

1992 • 95 citations

DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein.

1994 • 90 citations

Evaluation of Relative Promoter Strength in Primary Hepatocytes Using Optimized Lipofection

1991 • 86 citations

Human adenovirus encodes two proteins which have opposite effects on accumulation of alternatively spliced mRNAs.

1994 • 81 citations

A packaging cell line for propagation of recombinant adenovirus vectors containing two lethal gene-region deletions.

1995 • 81 citations

Adenovirus E4 open reading frame 4 protein autoregulates E4 transcription by inhibiting E1A transactivation of the E4 promoter

1996 • 78 citations

Dexamethasone enhancement of gene expression after direct hepatic DNA injection.

1994 • 78 citations

Inflammation-induced recombinant protein expression in vivo using promoters from acute-phase protein genes.

1995 • 69 citations

Adenovirus Early Region 4 and Viral DNA Synthesis

1993 • 63 citations

Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein

1994 • 59 citations

Regulated splicing of adenovirus type 5 E4 transcripts and regulated cytoplasmic accumulation of E4 mRNA

1993 • 52 citations

Human adenovirus encodes two proteins which have opposite effects on accumulation of alternatively spliced mRNAs

1994 • 46 citations

Unexpected position‐dependent expression of H‐2 and β2‐microglobulin/lacz transgenes

1992 • 42 citations

Mutation of the C/EBP binding sites in the Rous sarcoma virus long terminal repeat and gag enhancers

1993 • 40 citations

Adenovirus early region 4 is required for efficient virus particle assembly

1987 • 40 citations

Gene product of region E4 of adenovirus type 5 modulates accumulation of certain viral polypeptides

1988 • 35 citations

Mutually exclusive interaction of the adenovirus E4-6/7 protein and the retinoblastoma gene product with internal domains of E2F-1 and DP-1

1994 • 29 citations

Isolation and Characterization of cDNA Clones from Mouse Skeletal Muscle Actin mRNA

1986 • 28 citations

Stimulation of the adenovirus major late promoter in vitro by transcription factor USF is enhanced by the adenovirus DNA binding protein

1994 • 23 citations

The metabolism of host RNAs in cells infected by an adenovirus E4 mutant

1991 • 16 citations

Hepatitis B Virus X Protein Partially Substitutes for E1A Transcriptional Function during Adenovirus Infection

1996 • 12 citations

Factors Influencing Physiological Variations in the Activity of the Rous Sarcoma Virus Long Terminal Repeat

1993 • 9 citations