B Cell Repertoire Diversity and Clonal Expansion in Multiple Sclerosis Brain Lesions

Somatic generation of antibody diversity

1983 • 3,275 citations

Identification of autoantibodies associated with myelin damage in multiple sclerosis

1999 • 881 citations

PCR fidelity of pfu DNA polymerase and other thermostable DNA polymerases

1996 • 701 citations

Cerebrospinal fluid in the diagnosis of multiple sclerosis: a consensus report.

1994 • 680 citations

Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view

1992 • 653 citations

Mutation Drift and Repertoire Shift in the Maturation of the Immune Response

1987 • 635 citations

Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

1997 • 558 citations

Early Restriction of the Human Antibody Repertoire

1987 • 546 citations

Fidelity of DNA polymerases in DNA amplification.

1989 • 487 citations

The Role of CD40 Ligand in Costimulation and T‐Cell Activation

1996 • 441 citations

Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy

1998 • 434 citations

Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments.

1982 • 411 citations

Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping: correlation with immune status

1995 • 400 citations

Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells.

1997 • 373 citations

Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes.

1991 • 364 citations

Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. Correlation with immune status.

1994 • 345 citations

Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis.

1998 • 321 citations

Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, “minor” D segments or D-D recombination 1 1Edited By J. Karn

1997 • 300 citations

Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions.

1991 • 276 citations

Animal models

1994 • 276 citations

Experimental allergic encephalomyelitis: the balance between encephalitogenic T lymphocytes and demyelinating antibodies determines size and structure of demyelinated lesions

1988 • 206 citations

A serial study of new MS lesions and the white matter from which they arise

1998 • 201 citations

Antigen-Dependent Intrathecal Antibody Synthesis in the Normal Rat Brain: Tissue Entry and Local Retention of Antigen-Specific B Cells

1998 • 195 citations

Restricted use of V_H4 Germline segments in an acute multiple sclerosis brain

1998 • 176 citations

Neuropathology in multiple sclerosis: new concepts

1998 • 172 citations

Antimyelin basic protein and antimyelin antibody‐producing cells in multiple sclerosis

1990 • 133 citations

MULTIPLE SCLEROSIS: A QUANTITATIVE AND QUALITATIVE STUDY OF IMMUNOGLOBULIN‐CONTAINING CELLS IN THE CENTRAL NERVOUS SYSTEM

1980 • 122 citations

Multiple sclerosis: an autoimmune disease of multifactorial etiology

1992 • 95 citations

Representation of rearranged VH gene segments in the human adult antibody repertoire.

1995 • 87 citations

Relationship of the CD5 B cell to human tonsillar lymphocytes that express autoantibody-associated cross-reactive idiotypes.

1991 • 79 citations

Predominant V_Hgenes expressed in innate antibodies are associated with distinctive antigen-binding sites

1999 • 49 citations

Role of B-cell and Fc receptors in the selection of T-cell epitopes

1998 • 48 citations

On classification of post-mortem multiple sclerosis plaques for neuroscientists

1993 • 47 citations

Demyelinating Antibodies to Myelin Oligodendrocyte Glycoprotein and Galactocerebroside Induce Degradation of Myelin Basic Protein in Isolated Human Myelin

1997 • 47 citations

The long march of the cerebrospinal fluid profile indicative of clinical definite multiple sclerosis; and still marching

1988 • 40 citations

Multiple Sclerosis Brain Immunoglobulins Stimulate Myelin Basic Protein Degradation in Human Myelin: A New Cause of Demyelination

1989 • 38 citations

Host immunobiology and vaccine development

1997 • 35 citations

Antibody to myelin basic protein in extracts of multiple sclerosis brain.

1981 • 35 citations

Epitope spreading leads to myelin-specific autoimmune responses in SJL mice chronically infected with Theiler's virus.

1997 • 32 citations

Molecular characterization of human Ig heavy chain DIR genes.

1994 • 31 citations

The human immunoglobulin V(H) gene repertoire is genetically controlled and unaltered by chronic autoimmune stimulation.

1996 • 29 citations

Synergism in the Pathogenesis of EAE Induced by an MBP‐Specific T‐Cell Line and Monoclonal Antibodies to Galactocerebroside or a Myelin Oligodendroglial Glycoproteina

1988 • 24 citations

Cerebrospinal fluid concentrations of the complement MAC inhibitor CD59 in multiple sclerosis and patients with other neurological disorders

1994 • 12 citations

Clonally restricted B cells in peripheral blood of multiple sclerosis patients: Kappa/lambda staining patterns

1982 • 11 citations

The Role of T Cells in the Regulation of B Cell Tolerance

1997 • 11 citations

A cross‐reactive anti‐myelin basic protein idiotope in cerebrospinal fluid cells in multiple sclerosis

1998 • 11 citations