The human immunoglobulin V(H) gene repertoire is genetically controlled and unaltered by chronic autoimmune stimulation.

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

1988 • 19,632 citations

Revised Criteria for the Classification of Rheumatoid Arthritis

1990 • 7,730 citations

Sequences of proteins of immunological interest

1984 • 3,427 citations

The repertoire of human germline vH sequences reveals about fifty groups of VH segments with different hypervariable loops

1992 • 616 citations

Early Restriction of the Human Antibody Repertoire

1987 • 546 citations

The human immunoglobulin VH repertoire

1995 • 469 citations

A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q

1994 • 243 citations

T cell receptor V-segment frequencies in peripheral blood T cells correlate with human leukocyte antigen type.

1991 • 166 citations

Influence of HLA genes on T cell receptor V segment frequencies and expression levels in peripheral blood lymphocytes.

1993 • 135 citations

The physical organization of the human immunoglobulin heavy chain gene complex.

1990 • 113 citations

Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response.

1992 • 105 citations

“Homozygosity” for the HLA–DR shared epitope contributes the highest risk for rheumatoid arthritis concordance in identical twins

1994 • 93 citations

High-frequency representation of a single VH gene in the expressed human B cell repertoire.

1993 • 83 citations

A majority of Ig H chain cDNA of normal human adult blood lymphocytes resembles cDNA for fetal Ig and natural autoantibodies.

1993 • 81 citations

Expression of the immunoglobulin VH gene 51p1 is proportional to its germline gene copy number.

1996 • 78 citations

Evidence for the overexpression of the VH4-34 (VH4.21) Ig gene segment in the normal adult human peripheral blood B cell repertoire.

1995 • 75 citations

A fetally expressed immunoglobulin VH1 gene belongs to a complex set of alleles.

1993 • 74 citations

Identification and physical mapping of a polymorphic human T cell receptor V beta gene with a frequent null allele.

1993 • 57 citations

The expressed T cell receptor V gene repertoire of rheumatoid arthritis monozygotic twins: Rapid analysis by anchored polymerase chain reaction and enzyme‐linked immunosorbent assay

1993 • 50 citations

Chromosomal organization of the human VH4 gene family. Location of individual gene segments.

1993 • 47 citations

Reduced expression of a human V beta 6.1 T-cell receptor allele.

1993 • 43 citations

THE ARTHRITIS AND RHEUMATISM COUNCIL'S NATIONAL REPOSITORY OF FAMILY MATERIAL: PEDIGREES FROM THE FIRST 100 RHEUMATOID ARTHRITIS FAMILIES CONTAINING AFFECTED SIBLING PAIRS

1994 • 41 citations

Chromosomal organization of the heavy chain variable region gene segments comprising the human fetal antibody repertoire.

1992 • 39 citations

Differential expression of VH gene families in peripheral B cell repertoires of newborn or adult immunoglobulin H chain congenic mice.

1992 • 35 citations

From Human Autoantibodies to the Fetal Antibody Repertoire to B Cell Malignancy: It's a Small World After All

1990 • 34 citations

HAPPY mapping of a YAC reveals alternative haplotypes in the human immunoglobulin V_Hlocus

1993 • 33 citations

Influence of coding region polymorphism on the peripheral expression of a human TCR V beta gene.

1994 • 32 citations

Sequence analyses of three immunoglobulin G anti-virus antibodies reveal their utilization of autoantibody-related immunoglobulin Vh genes, but not V lambda genes.

1992 • 31 citations

Defining the genetic origins of three rheumatoid synovium-derived IgG rheumatoid factors.

1994 • 29 citations

Analysis of Immunoglobulin V_H Gene Repertoire by an Anchored PCR‐Elisa^a

1995 • 29 citations

Divergent T cell receptor γ repertoires in rheumatoid arthritis monozygotic twins

1993 • 20 citations

Regulation of the mature human T cell receptor gamma repertoire by biased V-J gene rearrangement.

1993 • 19 citations

V_HGenes of Human Autoantibodies

1990 • 18 citations

Autoantibodies and the Fetal Antibody Repertoire

1990 • 17 citations

Human IgH‐V Gene Repertoire in Neonatal Cord Blood, Adult Peripheral Blood, and EBV‐Transformed Cells^a

1995 • 17 citations

Heavy Chain Variable Region Gene Utilization in Human Antibodies

1990 • 13 citations

The Influence of Non‐HLA Genes on the Human T‐Cell Receptor Repertoire

1995 • 10 citations

V_H4.21 Expression in the Normal Human B‐Cell Repertoire

1995 • 9 citations

Monozygotic Rheumatoid Arthritis Twin Pairs Express Similar Levels of Conserved Immunoglobulin V Gene in Polyclonal Rheumatoid Factors Irrespective of Disease Status

1995 • 7 citations