Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

New diagnostic criteria for multiple sclerosis: Guidelines for research protocols

1983 • 7,404 citations

Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase

1988 • 4,259 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

Tumor necrosis factor identified in multiple sclerosis brain.

1989 • 793 citations

The role of clonal selection and somatic mutation in autoimmunity

1987 • 714 citations

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.

1993 • 691 citations

Analysis of somatic mutation in five B cell subsets of human tonsil.

1994 • 667 citations

Vaccination against autoimmune encephalomyelitis with T-lymphocite line cells reactive against myelin basic protein

1981 • 520 citations

The Role of CD40 Ligand in Costimulation and T‐Cell Activation

1996 • 441 citations

Selection for T-cell receptor Vβ–Dβ–Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis

1993 • 400 citations

The application of multifactorial cluster analysis in the staging of plaques in early multiple sclerosis. Identification and characterization of the primary demyelinating lesion

1997 • 326 citations

Organization of human immunoglobulin heavy chain diversity gene loci.

1988 • 317 citations

Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice

1984 • 311 citations

Animal models

1994 • 276 citations

Stable Expression and Somatic Hypermutation of Antibody V Regions in B-Cell Developmental Pathways

1989 • 271 citations

Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses

1987 • 230 citations

Experimental allergic encephalomyelitis: the balance between encephalitogenic T lymphocytes and demyelinating antibodies determines size and structure of demyelinated lesions

1988 • 206 citations

Heterogeneity of blood‐brain barrier changes in multiple sclerosis

1990 • 201 citations

The Evolution of B-Cell Clones

1990 • 185 citations

Restricted use of V_H4 Germline segments in an acute multiple sclerosis brain

1998 • 176 citations

Evolutionary nucleotide replacements in DNA

1979 • 169 citations

The use of chromosomal translocations to study human immunoglobulin gene organization: mapping DH segments within 35 kb of the C mu gene and identification of a new DH locus.

1988 • 155 citations

Antimyelin basic protein and antimyelin antibody‐producing cells in multiple sclerosis

1990 • 133 citations

Oligoclonal T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis.

1988 • 132 citations

Distribution of Mutations around Rearranged Heavy-Chain Antibody Variable-Region Genes

1990 • 129 citations

Anti‐myelin basic protein and anti‐proteolipid protein specific forms of multiple sclerosis

1994 • 107 citations

Novel rearrangements at the immunoglobulin D locus. Inversions and fusions add to IgH somatic diversity.

1989 • 103 citations

Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response.

1989 • 103 citations

Distribution of mutations around rearranged heavy-chain antibody variable-region genes.

1990 • 93 citations

In vivo labeling of blood T cells: Rapid traffic into cerebrospinal fluid in multiple sclerosis

1987 • 90 citations

Antibodies to Myelin-Associated Glycoprotein (MAG) in the cerebrospinal fluid of multiple sclerosis patients

1989 • 77 citations

Multiple Sclerosis. Pathology, Diagnosis and Management.

1983 • 58 citations

Persistent anti-myelin basic protein IgG antibody response in multiple sclerosis cerebrospinal fluid

1990 • 56 citations

Chromosomal organization of the human VH4 gene family. Location of individual gene segments.

1993 • 47 citations

The long march of the cerebrospinal fluid profile indicative of clinical definite multiple sclerosis; and still marching

1988 • 40 citations

Host immunobiology and vaccine development

1997 • 35 citations

Immunology of Multiple Sclerosis

1983 • 34 citations

Synergism in the Pathogenesis of EAE Induced by an MBP‐Specific T‐Cell Line and Monoclonal Antibodies to Galactocerebroside or a Myelin Oligodendroglial Glycoproteina

1988 • 24 citations

Synergism in the pathogenesis of EAE induced by an MBP-specific T cell line and monoclonal antibodies to Galacto-Cerebroside or to a myelin oligodendroglial glycoprotein

1987 • 4 citations