Regulation of human IgE synthesis. I. Human IgE synthesis in vitro is determined by the reciprocal antagonistic effects of interleukin 4 and interferon‐γ

IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2.

1988 • 939 citations

IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses.

1988 • 731 citations

IL-4 is required to generate and sustain in vivo IgE responses.

1988 • 671 citations

Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones.

1988 • 509 citations

Inhibition of intractable, nucleases with ribonucleoside-vanadyl complexes: isolation of messenger ribonucleic acid from resting lymphocytes

1979 • 461 citations

Human recombinant interleukin 4 induces Fc epsilon receptors (CD23) on normal human B lymphocytes.

1987 • 449 citations

Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones

1984 • 392 citations

Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1.

1986 • 355 citations

Two species of human Fcε receptor II ( ): Tissue-specific and IL-4-specific regulation of gene expression

1988 • 345 citations

IgE production by normal human B cells induced by alloreactive T cell clones is mediated by IL-4 and suppressed by IFN-gamma.

1988 • 315 citations

Interleukin 5 enhances interleukin 4‐induced IgE production by normal human B cells. The role of soluble CD23 antigen

1988 • 265 citations

Fc epsilon receptor, a specific differentiation marker transiently expressed on mature B cells before isotype switching.

1986 • 240 citations

Mitogen plus interleukin 4 induction of C epsilon transcripts in B lymphoid cells.

1988 • 208 citations

Human lymphocyte Fc receptor for IgE: sequence homology of its cloned cDNA with animal lectins.

1987 • 194 citations

Possible role of human lymphocyte receptor for IgE (CD23) or its soluble fragments in the in vitro synthesis of human IgE.

1988 • 175 citations

Production and characterization of a monoclonal antibody specific for the human lymphocyte low affinity receptor for IgE: CD 23 is a low affinity receptor for IgE.

1987 • 159 citations

Binding the low affinity Fc epsilon R on B cells suppresses ongoing human IgE synthesis.

1989 • 110 citations

Modulation of IL‐4‐induced human IgE production in vitro by IFN‐γ and IL‐5: The role of soluble CD23 (s‐CD23)

1989 • 80 citations

Development of polyclonal and monoclonal antibodies for immunoassay and neutralization of human interleukin-4

1989 • 77 citations

Human recombinant interleukin 4 induces normal B cells to produce soluble CD23/IgE‐binding factor analogous to that spontaneously released by lymphoblastoid B cell lines

1988 • 76 citations

Influence of recombinant IL-4, IFN-alpha, and IFN-gamma on the production of human IgE-binding factor (soluble CD23).

1989 • 76 citations

Regulation of Fc epsilon R2/CD23 gene expression by cytokines and specific ligands (IgE and anti-Fc epsilon R2 monoclonal antibody). Variable regulation depending on the cell types.

1988 • 74 citations

Epitope mapping of recombinant human gamma interferon using monoclonal antibodies

1989 • 47 citations

A monoclonal anti-IgE antibody against an epitope (amino acids 367-376) in the CH3 domain inhibits IgE binding to the low affinity IgE receptor (CD23).

1988 • 40 citations