Roles of molecular chaperones in protein targeting to mitochondria

A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

1988 • 1,504 citations

Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding

1992 • 965 citations

Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria

1989 • 933 citations

Proteins as molecular chaperones

1987 • 910 citations

Polypeptide chain binding proteins: Catalysts of protein folding and related processes in cells

1989 • 884 citations

Chaperonin-mediated protein folding at the surface of groEL through a 'molten globule'-like intermediate

1991 • 853 citations

Peptide Binding and Release by Proteins Implicated as Catalysts of Protein Assembly

1989 • 763 citations

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins

1990 • 756 citations

Stress proteins in biology and medicine

1990 • 731 citations

Binding of a specific ligand inhibits import of a purified precursor protein into mitochondria

1986 • 723 citations

Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis

1989 • 676 citations

Molecular chaperones: proteins essential for the biogenesis of some macromolecular structures

1989 • 491 citations

Transport of proteins into mitochondria: Translocational intermediates spanning contact sites between outer and inner membranes

1985 • 470 citations

THE ENZYMOLOGY OF PROTEIN TRANSLOCATION ACROSS THE Escherichia coli PLASMA MEMBRANE

1991 • 442 citations

Cytochromes c1 and b2 are sorted to the intermembrane space of yeast mitochondria by a stop-transfer mechanism

1992 • 422 citations

Mitochondrial protein import: Identification of processing peptidase and of PEP, a processing enhancing protein

1988 • 388 citations

70-kD heat shock-related protein is one of at least two distinct cytosolic factors stimulating protein import into mitochondria.

1988 • 380 citations

Role of an energized inner membrane in mitochondrial protein import. Delta psi drives the movement of presequences.

1991 • 372 citations

Characterization of the yeast HSP60 gene coding for a mitochondrial assembly factor

1989 • 335 citations

THE MITOCHONDRIAL PROTEIN IMPORT APPARATUS

1990 • 311 citations

Mitochondrial proteins essential for viability mediate protein import into yeast mitochondria

1991 • 278 citations

How do polypeptides cross the mitochondrial membranes?

1990 • 246 citations

SSC1, an Essential Member of the Yeast HSP70 Multigene Family, Encodes a Mitochondrial Protein

1989 • 242 citations

A precursor protein partly translocated into yeast mitochondria is bound to a 70 kd mitochondrial stress protein.

1990 • 242 citations

Antifolding activity of hsp60 couples protein import into the mitochondrial matrix with export to the intermembrane space

1992 • 233 citations

Sequential action of mitochondrial chaperones in protein import into the matrix.

1991 • 221 citations

Translocation arrest by reversible folding of a precursor protein imported into mitochondria. A means to quantitate translocation contact sites.

1989 • 212 citations

SSC1, a member of the 70-kDa heat shock protein multigene family of Saccharomyces cerevisiae, is essential for growth.

1987 • 205 citations

Unfolding and refolding of a purified precursor protein during import into isolated mitochondria.

1988 • 182 citations

Heat-shock proteins DnaK and GroEL facilitate export of LacZ hybrid proteins in E. coli

1990 • 175 citations

Polypeptides traverse the mitochondrial envelope in an extended state

1990 • 172 citations

A homologue of the bacterial heat-shock gene DnaJ that alters protein sorting in yeast

1991 • 117 citations

Purified presequence binding factor (PBF) forms an import-competent complex with a purified mitochondrial precursor protein.

1990 • 113 citations

Protein import into the yeast mitochondrial matrix. A new translocation intermediate between the two mitochondrial membranes.

1991 • 107 citations

Precursor proteins in transit through mitochondrial contact sites interact with hsp70 in the matrix

1990 • 98 citations

Mitochondrial preproteins en route from the outer membrane to the inner membrane are exposed to the intermembrane space

1991 • 90 citations

Translocation of proteins across the mitochondrial inner membrane, but not into the outer membrane, requires nucleoside triphosphates in the matrix.

1989 • 87 citations

9 Properties of the Escherichia coli Heat Shock Proteins and Their Role in Bacteriophage λ Growth

1990 • 76 citations

Localization and assembly into the Escherichia coli envelope of a protein required for entry of colicin A

1989 • 56 citations

Targeting of a chemically pure preprotein to mitochondria does not require the addition of a cytosolic signal recognition factor.

1992 • 55 citations

Protein import into mitochondria and peroxisomes

1990 • 53 citations

Translocation arrest by reversible folding of a precursor protein imported into mitochondria

1989 • 37 citations