Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme

Tissue sulfhydryl groups

1959 • 25,130 citations

Trypanothione: A Novel Bis(glutathionyl)spermidine Cofactor for Glutathione Reductase in Trypanosomatids

1985 • 668 citations

The catalytic mechanism of glutathione reductase as derived from x-ray diffraction analyses of reaction intermediates.

1983 • 323 citations

Purification and characterization of trypanothione reductase from Crithidia fasciculata, a new member of the family of disulfide-containing flavoprotein reductases

1986 • 267 citations

Glutathione Reductase from Human Erythrocytes

1982 • 238 citations

Human Glutathione Reductase: Purification of the Crystalline Enzyme from Erythorocytes

1974 • 215 citations

Deficient metabolic utilization of hydrogen peroxide in Trypanosoma cruzi

1980 • 191 citations

"Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease.

1988 • 181 citations

Glutathione Reductase from Human Erythrocytes. Catalytic Properties and Aggregation

1976 • 178 citations

Glutathione Reductase from Human Erythrocytes

1977 • 175 citations

Free Radical Metabolites in the Mode of Action of Chemotherapeutic Agents and Phagocytic Cells on Trypanosoma cruzi

1984 • 173 citations

Glutathione reductase from Escherichia coli: cloning and sequence analysis of the gene and relationship to other flavoprotein disulfide oxidoreductases

1986 • 163 citations

Generation of superoxide anion and hydrogen peroxide induced by nifurtimox in Trypanosoma cruzi

1979 • 136 citations

Biochemistry of Parasitic Protozoa

1977 • 132 citations

Isolation, characterization, and turnover of glutathionylspermidine from Escherichia coli.

1975 • 119 citations

Substrate specificity of the flavoprotein trypanothione disulfide reductase from Crithidia fasciculata

1987 • 93 citations

Oxidative Stress as a Defense Mechanism Against Parasitic Infections

1987 • 91 citations

Interaction of a glutathione S‐conjugate with glutathione reductase Kinetic and X‐ray crystallographic studies

1984 • 86 citations

Trypanothione reductase of Trypanosoma congolense: gene isolation, primary sequence determination, and comparison to glutathione reductase

1988 • 84 citations

Glutathione Reductase from Human Erythrocytes. Amino-Acid Sequence of the Structurally Known FAD-Binding Domain

1981 • 84 citations

Hydrogen peroxide metabolism in Trypanosoma brucei

1986 • 66 citations

Purification by affinity chromatography of yeast glutathione reductase, the enzyme responsible for the NADPH-dependent reduction of the mixed disulfide of coenzyme A and glutathione

1977 • 66 citations

The production of superoxide radicals in reactions of the herbicide diquat

1971 • 65 citations

The evolution of glutathione metabolism in phototrophic microorganisms

1987 • 65 citations

Formation of hydroxyl radicals from the paraquat radical cation, demonstrated by a highly specific gas chromatographic technique. The role of superoxide radical anion, hydrogen peroxide, and glutathione reductase

1982 • 65 citations

The biosynthesis of trypanothione and N1-glutathionylspermidine in Crithidia fasciculata

1986 • 61 citations

A branching reaction mechanism of glutathione reductase

1973 • 60 citations

Biochemistry of Parasitic Protozoa.

1978 • 58 citations

Biochemistry of trypanosomiasis and rational approaches to chemotherapy

1982 • 43 citations

Glutathione reductase in evolution

1983 • 33 citations

Inhibition of glutathione reductase by interaction of 2,4,6‐trinitrobenzenesulfonate with the active‐site dithiol

1979 • 33 citations

Increased biliary secretion and loss of hepatic glutathione in rat liver after nifurtimox treatment

1983 • 33 citations

Crystals of human erythrocyte glutathione reductase

1975 • 30 citations

Proteinkristallographie und Computer‐Graphik – auf dem Weg zu einer planvollen Arzneimittelentwicklung

1986 • 28 citations

Synthesis of the trypanosomatid metabolites trypanothione, and N 1-mono- and N 8-mono-glutathionylspermidine

1986 • 25 citations

A cytosolic FAD-containing enzyme catalyzing cytochrome c reduction in Trypanosoma cruzi. I. Purification and some properties

1985 • 20 citations

Oxidase activity of glutathione reductase effected by 2,4,6‐trinitrobenzenesulfonate

1980 • 17 citations

Flavoenzymes as drug targets

1984 • 9 citations

A cytosolic flavin-containing enzyme catalyzing reduction of cytochrome c in Trypanosoma cruzi: Kinetic studies with cytochrome c as substrate

1985 • 4 citations

Biochemical and technical considerations regarding the mass production of certain parasitic protozoa.

1977 • 4 citations