Biochemistry of trypanosomiasis and rational approaches to chemotherapy

Biology of the Kinetoplastida

1978 • 691 citations

Localization of nine glycolytic enzymes in a microbody‐like organelle in Trypanosoma brucei: The glycosome

1977 • 581 citations

The Molecular Biology of Trypanosomes

1982 • 249 citations

Trypanosomiasis: An Approach to Chemotherapy by the Inhibition of Carbohydrate Catabolism

1976 • 151 citations

Inhibition of glutathione synthesis as a chemotherapeutic strategy for trypanosomiasis.

1981 • 140 citations

Generation of superoxide anion and hydrogen peroxide induced by nifurtimox in Trypanosoma cruzi

1979 • 136 citations

Isolation and characterization of kinetoplast DNA from bloodstream form of Trypanosoma brucei.

1978 • 134 citations

Uptake of the trypanocidal drug suramin by bloodstream forms of Trypanosoma brucei and its effect on respiration and growth rate in vivo

1980 • 113 citations

Subcellular Compartmentation of Glycolytic Intermediates in Trypanosoma brucei

1981 • 101 citations

New approach to screening drugs for activity against African trypanosomes

1977 • 101 citations

Content, Synthesis, and Function of Polyamines in Trypanosomatids: Relationship to Chemotherapy1^,2

1981 • 86 citations

An approach to the development of new drugs for African trypanosomiasis.

1978 • 74 citations

Transcription of kinetoplast DNA in Trypanosoma brucei bloodstream and culture forms

1981 • 73 citations

Trypanosoma cruzi: Allopurinol in the treatment of mice with experimental acute Chagas disease

1981 • 68 citations

Trypanosoma brucei: Preparation and some properties of a multienzyme complex catalysing part of the glycolytic pathway

1980 • 42 citations

The interactionin vitrobetween bovine immunoglobulin and juvenileFasciola hepatica

1981 • 38 citations

Trypanosoma brucei: The effect of glycerol on the anaerobic metabolism of glucose

1980 • 37 citations

The isolation and characterisation of particulate sn-glycerol-3-phosphate oxidase from Trypanosoma brucei

1977 • 37 citations

Trypanocidal activity of daunorubicin and related compounds

1981 • 36 citations

Pleomorphism and the problem of recrudescent parasitaemia following treatment with salicylhydroxamic acid (SHAM) in African trypanosomiasis

1980 • 26 citations

Alternate metabolic pathways in protozoan energy metabolism.

1981 • 26 citations

Pyrazolopyrimidine metabolism in African trypanosomes: Metabolic similarities to Trypanosoma cruzi and Leishmania spp.

1980 • 24 citations

The Replication of Kinetoplast DNA

1980 • 17 citations

Trypanosoma brucei: Host parasite interaction in parasite destruction by salicylhydroxamic acid and glycerol in mice

1981 • 12 citations