Free Radical Metabolites in the Mode of Action of Chemotherapeutic Agents and Phagocytic Cells on Trypanosoma cruzi

Superoxide Dismutase

1969 • 12,578 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen

1972 • 3,744 citations

Biology of disease: free radicals and tissue injury.

1982 • 3,078 citations

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.

1981 • 2,777 citations

Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions.

1982 • 1,241 citations

Superoxide, hydrogen peroxide, and singlet oxygen in lipid peroxidation by a xanthine oxidase system.

1975 • 969 citations

Superoxide‐dependent production of hydroxyl radical catalyzed by iron—EDTA complex

1978 • 876 citations

Toxic drug effects associated with oxygen metabolism: Redox cycling and lipid peroxidation

1981 • 650 citations

A general mechanism for microsomal activation of quinone anticancer agents to free radicals.

1978 • 645 citations

Organic chemistry of stable free radicals

1968 • 466 citations

Oxygen Radicals, Hydrogen Peroxide, and Oxygen Toxicity

1976 • 430 citations

DNA strand scission by enzymically generated oxygen radicals

1981 • 428 citations

The Role of Free Radical Reactions in Biological Systems

1976 • 374 citations

Generation of Hydrogen Peroxide in Erythrocytes by Hemolytic Agents^*

1964 • 360 citations

One-electron-transfer reactions in biochemical systems V. Difference in the mechanism of quinone reduction by the NADH dehydrogenase and the NAD(P)H dehydrogenase (DT-diaphorase)

1970 • 335 citations

Activation of macrophages in vivo and in vitro. Correlation between hydrogen peroxide release and killing of Trypanosoma cruzi.

1979 • 334 citations

Spin-trapping and direct electron spin resonance investigations of the redox metabolism of quinone anticancer drugs

1980 • 317 citations

The role of catalytic superoxide formation in the O2 inhibition of nitroreductase

1975 • 306 citations

Free-Radical Intermediates in the Metabolism of Toxic Chemicals

1982 • 197 citations

Deficient metabolic utilization of hydrogen peroxide in Trypanosoma cruzi

1980 • 191 citations

Activation of pharmacologic agents to radical intermediates

1982 • 190 citations

Radiosensitizers of hypoxic cells in solid tumours

1976 • 168 citations

Free radicals in pharmacology and toxicology--selected topics.

1981 • 167 citations

Peroxide removal by selenium-dependent and selenium-independent glutathione peroxidases in hemoglobin-free perfused rat liver.

1978 • 167 citations

Secretion of oxygen intermediates: role in effector functions of activated macrophages.

1982 • 146 citations

Inhibitory Action of Gossypol on Enzymes and Growth of Trypanosoma cruzi

1982 • 145 citations

Generation of superoxide anion and hydrogen peroxide induced by nifurtimox in Trypanosoma cruzi

1979 • 136 citations

The metabolism of 4-nitroquinoline-1-oxide, a carcinogen. 3. An enzyme catalyzing the conversion of 4-nitroquinoline-1-oxide to 4-hydroxyaminoquinoline-1-oxide in rat liver and hepatomas.

1966 • 130 citations

Present status of chemotheraphy and chemoprophylaxis of human trypanosomiasis in the Western Hemisphere

1979 • 122 citations

Effect of β-lapachone on superoxide anion and hydrogen peroxide production in Trypanosoma cruzi

1978 • 112 citations

Iron-containing superoxide dismutase from Crithidia fasciculata. Purification, characterization, and similarity to Leishmanial and trypanosomal enzymes.

1983 • 109 citations

In vitroandin vivoevaluation of the toxicity of 1,4-naphthoquinone and 1,2-naphthoquinone derivatives againstTrypanosoma cruzi

1978 • 109 citations

STUDIES ON SUCCINIC DEHYDROGENASE

1956 • 107 citations

Pyrazolopyrimidine metabolism in the pathogenic trypanosomatidae

1983 • 107 citations

Chemotherapy of parasitic infections

1978 • 106 citations

Toxicity of Nitro Compounds Toward Hypoxic Mammalian Cells In Vitro: Dependence on Reduction Potential

1980 • 104 citations

Chemical and biochemical aspects of superoxide and superoxide dismutase

1980 • 103 citations

Spectroscopic Characteristics and Some Chemical Properties of N-Methylphenazinium Methyl Sulfate (Phenazine Methosulfate) and Pyocyanine at the Semiquinoid Oxidation Level

1964 • 102 citations

Bioactivation of the antitumor drugs 9-hydroxyellipticine and derivatives by a peroxidase-hydrogen peroxide system

1981 • 100 citations

Lipid peroxidation and the generation of free radicals, superoxide anion, and hydrogen peroxide in β-lapachone-treated Trypanosoma cruzi epimastigotes

1978 • 86 citations

Free-Radical Intermediates in the Antiparasitic Action of Drugs and Phagocytic Cells

1984 • 86 citations

Mechanism of nifurtimox toxicity in different forms of Trypanosoma cruzi

1981 • 84 citations

Hydrogen peroxide generation inTrypanosoma cruzi

1977 • 80 citations

Biochemical and ultrastructural alterations produced by miconazole and econazole in Trypanosoma cruzi

1981 • 80 citations

Light-Enhanced Free Radical Formation and Trypanocidal Action of Gentian Violet (Crystal Violet)

1983 • 80 citations

Generation of free radicals induced by nifurtimox in mammalian tissues.

1981 • 79 citations

Trypanosoma cruzi: Ultrastructural and metabolic alterations of epimastigotes by β-lapachone

1977 • 71 citations

Superoxide dismutase and oxygen toxicity.

1981 • 66 citations

Lethal action and metabolic effects of streptonigrin on Escherichia coli.

1968 • 62 citations

Production of superoxide anion during the oxidation of hemoglobin by menadione

1976 • 62 citations

Localization of peroxidase activity inTrypanosoma cruzi microbodies

1976 • 60 citations

T. cruzi: sensitization to macrophage killing by eosinophil peroxidase.

1982 • 59 citations

Ultrastructural and cytochemical changes in spermatogonia and Sertoli cells of whole‐body irradiated mice

1966 • 59 citations

Action of clinically utilized 5-nitroimidazoles on microorganisms.

1981 • 51 citations

On the mechanism of reductive activation in the mode of action of some anticancer drugs

1982 • 51 citations

Evaluation of the toxicity of 3-allyl-β-lapachone against Trypanosma cruzi bloodstream forms

1980 • 47 citations

Application of Radiation Chemistry to Biology

1977 • 46 citations

Destruction of leishmania mexicana amazonensis amastigotes within macrophages in culture by phenazine methosulfate and other electron carriers

1982 • 46 citations

Biological Basis of Detoxication of Oxygen Free Radicals

1983 • 44 citations

Nitrofuran enhancement of microsomal electron transport, superoxide anion production and lipid peroxidation

1981 • 44 citations

Role of polymorphonuclear cells in chagas' disease. I. Uptake and mechanisms of destruction of intracellular (amastigote) forms of Trypanosoma cruzi by human neutrophils

1984 • 43 citations

Superoxide anion production and trypanocidal action of naphthoquinones on Trypanosoma cruzi

1978 • 39 citations

Cytochrome P-450 and Drug Metabolism in Trypanosoma cruzi : Effects of Phenobarbital

1976 • 38 citations

Reconstitution of a variant macrophage cell line defective in oxygen metabolism with a H2O2-generating system.

1982 • 37 citations

Primaquine-mediated oxidative metabolism in the human red cell

1982 • 36 citations

Growth of Trypanosoma cruzi in a cloned macrophage cell line and in a variant defective in oxygen metabolism

1983 • 36 citations

Role of reactive oxygen and metabolite binding in drug toxicity

1982 • 36 citations

Reduced Oxygen By-Products and White Blood Cells

1982 • 35 citations

Increased biliary secretion and loss of hepatic glutathione in rat liver after nifurtimox treatment

1983 • 33 citations

Oxygen‐derived radicals from Trypanosoma cruzi‐stimulated human neutrophils

1983 • 31 citations

Studies with primaquine in vitro: superoxide radical formation and oxidation of haemoglobin.

1978 • 29 citations

Effect of beta-lapachone on hydrogen peroxide production in Trypanosoma cruzi.

1978 • 28 citations

Hemoproteins in Trypanosoma cruzi with emphasis on microsomal pigments

1976 • 27 citations

Chemotherapy of Trypanosoma cruzi Infections

1975 • 27 citations

Ultrastructural alterations and peroxide formation induced by naphthoquinones in different stages ofTrypanosoma cruzi

1978 • 27 citations

Purification of the of Trypanosoma cruzi

1981 • 26 citations

Microsomal Hemoproteins in Trypanosoma cruzi

1971 • 18 citations

Effect of mitomycin C, actinomycin D, and pyrimidine analogs on the growth rate, protein and nucleic acid synthesis, and on the viability of Trypanosoma cruzi

1966 • 17 citations

FREE RADICAL INTERMEDIATES IN THE TRYPANOCIDAL ACTION OF DRUGS AND PHAGOCYTIC CELLS

1984 • 16 citations

Chloroquine- and primaquine-induced alterations of glucose metabolism in the uninfected red cell

1981 • 16 citations

Light-enhanced genetic toxicity of crystal violet

1982 • 15 citations

The Structure of the Free Radical Produced from Carcinogenic 4-Hydroxyaminoquinoline 1-Oxide

1967 • 14 citations

Generation of free radicals from phenazine methosulfate in Trypanosoma cruzi epimastigotes.

1978 • 13 citations

Crithidia fasciculata: a catalase-containing trypanosomatid sensitive to nitroheterocyclic drugs

1982 • 13 citations

Tropical diseases encountered in Canada: 1. Chagas' disease.

1980 • 13 citations

Effect of Primaquine on Experimental Trypanosoma cruzi Infection.

1951 • 12 citations

Cytochemical study of enzymes of the respiratory chain in the life cycle of Trypanosoma cruzi.Chagas. 1909. I. Enzymes of the respiratory chain at all stages of the life cycle, in vivo and in culture.

1968 • 11 citations

Production of hydrogen peroxide by 4 hydroxyaminoquinoline 1-oxide.

1969 • 11 citations

Destruction of Intracellular Trypanosoma cruzi After Treatment of Infected Macrophages with Cationic Electron Carriers

1983 • 10 citations

Activity of certain 6-methoxy-8-aminoquinolines against Trypanosoma cruzi.

1952 • 10 citations

Metabolic Requirements for the Damage of Trypanosoma cruzi Epimastigotes by Human Polymorphonuclear Leukocytes

1982 • 8 citations

A rotating peroxy group. The ESR spectrum of 17O-enriched triphenylmethylperoxyl

1974 • 7 citations

Loss of Infectivity of Mycobacterial and Protozoal Exoplasmic Parasites after Exposure in vitro to the Polyenzymic Cocktail ‘PIGO’

1976 • 7 citations

Effects of 9-hydroxy ellipticine on in vitro transcription of Trypanosoma cruzi DNAs

1977 • 7 citations

Xanthine oxidase in calf serum: formation of oxygen metabolites that are toxic for Trypanosoma cruzi in culture.

1983 • 6 citations

Germicidal activity of a polyenzymic system on pathogenic protozoa in vitro.

1975 • 5 citations