Oxidative Stress as a Defense Mechanism Against Parasitic Infections

Oxidative Stress: Introductory Remarks

1985 • 979 citations

Trypanothione: A Novel Bis(glutathionyl)spermidine Cofactor for Glutathione Reductase in Trypanosomatids

1985 • 668 citations

Sequencing of Proteins and Peptides

1981 • 338 citations

The catalytic mechanism of glutathione reductase as derived from x-ray diffraction analyses of reaction intermediates.

1983 • 323 citations

Susceptibility of leishmania to oxygen intermediates and killing by normal macrophages

1981 • 267 citations

Purification and characterization of trypanothione reductase from Crithidia fasciculata, a new member of the family of disulfide-containing flavoprotein reductases

1986 • 267 citations

Glutathione Reductase from Human Erythrocytes

1982 • 238 citations

Modern methods in protein chemistry

1983 • 221 citations

Tumor cell anti-oxidant defenses. Inhibition of the glutathione redox cycle enhances macrophage-mediated cytolysis

1981 • 220 citations

Induction of crisis forms in the human malaria parasite Plasmodium falciparum by gamma-interferon-activated, monocyte-derived macrophages.

1984 • 184 citations

Glutathione Reductase from Human Erythrocytes

1977 • 175 citations

Free Radical Metabolites in the Mode of Action of Chemotherapeutic Agents and Phagocytic Cells on Trypanosoma cruzi

1984 • 173 citations

Oxygen-derived Free Radicals in the Pathogenesis of Parasitic Disease

1986 • 143 citations

Inhibition of glutathione synthesis as a chemotherapeutic strategy for trypanosomiasis.

1981 • 140 citations

Generation of superoxide anion and hydrogen peroxide induced by nifurtimox in Trypanosoma cruzi

1979 • 136 citations

The Role of Cell-Mediated Immune Responses in Resistance to Malaria, with Special Reference to Oxidant Stress

1983 • 131 citations

Peroxidase-mediated toxicity to schistosomula of Schistosoma mansoni.

1981 • 128 citations

Familial deficiency of glutathione reductase in human blood cells

1976 • 122 citations

The Chemistry of Favism‐Inducing Compounds

1982 • 114 citations

Role of Cell-generated Hydrogen Peroxide in Granulocyte-mediated Killing of Schistosomula of Schistosoma mansoni In Vitro

1981 • 113 citations

A role for oxygen-dependent mechanisms in killing of Leishmania donovani tissue forms by activated macrophages.

1982 • 102 citations

Interaction of a glutathione S‐conjugate with glutathione reductase Kinetic and X‐ray crystallographic studies

1984 • 86 citations

Content, Synthesis, and Function of Polyamines in Trypanosomatids: Relationship to Chemotherapy1^,2

1981 • 86 citations

Mechanism of nifurtimox toxicity in different forms of Trypanosoma cruzi

1981 • 84 citations

Glutathione Reductase from Human Erythrocytes. Amino-Acid Sequence of the Structurally Known FAD-Binding Domain

1981 • 84 citations

An approach to the development of new drugs for African trypanosomiasis.

1978 • 74 citations

Hydrogen peroxide metabolism in Trypanosoma brucei

1986 • 66 citations

Formation of hydroxyl radicals from the paraquat radical cation, demonstrated by a highly specific gas chromatographic technique. The role of superoxide radical anion, hydrogen peroxide, and glutathione reductase

1982 • 65 citations

Biochemistry of trypanosomiasis and rational approaches to chemotherapy

1982 • 43 citations

Some new congeners of the anticancer agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) synthesis of bifunctional analogs and water soluble derivatives and preliminary evaluation of their chemotherapeutic potential

1976 • 41 citations

Inhibitory effect of a fava bean component on the in vitro development of Plasmodium falciparum in normal and glucose-6-phosphate dehydrogenase deficient erythrocytes

1983 • 40 citations

Superoxide anion production and trypanocidal action of naphthoquinones on Trypanosoma cruzi

1978 • 39 citations

Mitochondrial adenylate kinase (AK2) from bovine heart. The complete primary structure

1986 • 35 citations

Inhibition of glutathione reductase by interaction of 2,4,6‐trinitrobenzenesulfonate with the active‐site dithiol

1979 • 33 citations

Malaria, favism and glucose-6-phosphate dehydrogenase deficiency

1975 • 29 citations

Synthesis of the trypanosomatid metabolites trypanothione, and N 1-mono- and N 8-mono-glutathionylspermidine

1986 • 25 citations

Macrophages as effector cells in immunity to malaria

1985 • 22 citations

Active site-specific inhibition by 1,3-bis(2-chloroethyl)-1-nitrosourea of two genetically homologous flavoenzymes: glutathione reductase and lipoamide dehydrogenase.

1985 • 21 citations

What is tumour necrosis factor really for?

1984 • 14 citations

Nitrosoureas

1985 • 13 citations

On the geometry of leukocyte NADPH‐oxidase, a membrane flavoenzyme

1983 • 13 citations

Antimalarials

1985 • 11 citations

Flavoenzymes as drug targets

1984 • 9 citations

Disease as Factor in World Food Problem

1968 • 4 citations

Flavoproteins of Known Three-Dimensional Structure

1983 • 4 citations