IL-4 and IL-10 Antagonize IL-12-Mediated Protection Against Acute Vaccinia Virus Infection with a Limited Role of IFN-γ and Nitric Oxide Synthetase 2

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

NITRIC OXIDE AND MACROPHAGE FUNCTION

1997 • 4,106 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.

1989 • 2,118 citations

Impaired immune and acute-phase responses in interleukin-6-deficient mice

1994 • 1,776 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

Immune Response in Mice that Lack the Interferon-γ Receptor

1993 • 1,570 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

1995 • 1,454 citations

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

1993 • 1,409 citations

A TH1→TH2 switch is a critical step in the etiology of HIV infection

1993 • 1,403 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

Disruption of the murine IL-4 gene blocks Th2 cytokine responses

1993 • 1,197 citations

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1996 • 1,182 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1996 • 959 citations

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.

1996 • 920 citations

Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase

1993 • 825 citations

Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines

1995 • 686 citations

Immunology Taught by Viruses

1996 • 656 citations

Mechanism of Suppression of Cell-Mediated Immunity by Measles Virus

1996 • 564 citations

Expression of Interleukin-10 Activity by Epstein-Barr Virus Protein BCRF1

1990 • 539 citations

Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation

1994 • 509 citations

Genetically resistant mice lacking interleukin‐12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response

1996 • 483 citations

Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration.

1995 • 458 citations

Measles Virus Suppresses Cell-mediated Immunity by Interfering with the Survival and Functions of Dendritic and T Cells

1997 • 431 citations

Characterization of early IL-12, IFN-alphabeta, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection.

1996 • 413 citations

An absolute and restricted requirement for IL-12 in natural killer cell IFN-gamma production and antiviral defense. Studies of natural killer and T cell responses in contrasting viral infections.

1996 • 384 citations

Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells.

1991 • 372 citations

Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors

1995 • 353 citations

Switch of CD8 T Cells to Noncytolytic CD8 ^- CD4 ^- Cells that Make T _H 2 Cytokines and Help B Cells

1993 • 343 citations

An interleukin 4 (IL-4)-independent pathway for CD4⁺T cell IL-4 production is revealed in IL-4 receptor-deficient mice

1997 • 334 citations

Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection.

1994 • 290 citations

The roles of perforin‐ and Fas‐dependent cytotoxicity in protection against cytopathic and noncytopathic viruses

1995 • 286 citations

Influenza virus-specific CD4+ T helper type 2 T lymphocytes do not promote recovery from experimental virus infection.

1994 • 283 citations

The lymphoreticular system in triggering virus plus self-specific cytotoxic T cells: evidence for T help.

1978 • 268 citations

Cytokines and immunity to viral infections

1997 • 256 citations

Nitric oxide inhibits viral replication in murine myocarditis.

1996 • 249 citations

Response to influenza infection in mice with a targeted disruption in the interferon gamma gene.

1993 • 247 citations

Gamma interferon-dependent clearance of cytomegalovirus infection in salivary glands

1992 • 243 citations

Resistance to and Recovery from Lethal Influenza Virus Infection in B Lymphocyte–deficient Mice

1997 • 239 citations

Interleukin-12 inhibits hepatitis B virus replication in transgenic mice

1997 • 237 citations

Effects of IL-12 on the response and susceptibility to experimental viral infections.

1994 • 233 citations

A case for cytokines as effector molecules in the resolution of virus infection

1993 • 216 citations

Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids.

1995 • 215 citations

Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor.

1997 • 211 citations

Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes

1990 • 205 citations

Differences between IL-4Rα-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses

1998 • 204 citations

Both innate and acquired immunity to Listeria monocytogenes infection are increased in IL-10-deficient mice.

1997 • 202 citations

Immunobiology of lnterleukin-12

1998 • 191 citations

Intracellular Antimicrobial Activity in the Absence of Interferon-γ: Effect of Interleukin-12 in Experimental Visceral Leishmaniasis in Interferon-γ Gene-disrupted Mice

1997 • 162 citations

Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factor

1994 • 153 citations

Mice Lacking IL-12 Develop Polarized Th1 Cells During Viral Infection

1998 • 149 citations

CD40-CD40 ligand interactions are critical in T-B cooperation but not for other anti-viral CD4+ T cell functions.

1996 • 149 citations

IL-12 Is Not Required for Induction of Type 1 Cytokine Responses in Viral Infections

1999 • 147 citations

Importance of interferons in recovery from mousepox

1993 • 146 citations

Suppression of Herpes Simplex Virus Type 1 (HSV-1)–induced Pneumonia in Mice by Inhibition of Inducible Nitric Oxide Synthase (iNOS, NOS2)

1997 • 145 citations

Anti-IL-4 treatment at immunization modulates cytokine expression, reduces illness, and increases cytotoxic T lymphocyte activity in mice challenged with respiratory syncytial virus.

1994 • 145 citations

Effects of TH1 and TH2 cytokines on CD8+ cell response against human immunodeficiency virus: implications for long-term survival.

1995 • 139 citations

Interleukin-4 causes delayed virus clearance in influenza virus-infected mice

1996 • 138 citations

Interleukin-4 mediates down regulation of antiviral cytokine expression and cytotoxic T-lymphocyte responses and exacerbates vaccinia virus infection in vivo

1996 • 132 citations

Cytokine receptors encoded by poxviruses: a lesson in cytokine biology

1995 • 126 citations

Poliovirus-specific CD4+ Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor.

1995 • 121 citations

Interleukin-12 gene expression after viral infection in the mouse

1995 • 119 citations

Herpes simplex virus type 1-mediated up-regulation of IL-12 (p40) mRNA expression. Implications in immunopathogenesis and protection.

1996 • 118 citations

Immunodeficient mice recover from infection with vaccinia virus expressing interferon‐γ

1990 • 117 citations

Overexpression of interleukin-4 delays virus clearance in mice infected with respiratory syncytial virus

1997 • 113 citations

IL-12 in conjunction with dendritic cells enhances antiviral CD8+ CTL responses in vitro.

1996 • 111 citations

Interferon gamma is involved in the recovery of athymic nude mice from recombinant vaccinia virus/interleukin 2 infection.

1990 • 110 citations

Inhibition of viral replication by nitric oxide and its reversal by ferrous sulfate and tricarboxylic acid cycle metabolites.

1995 • 108 citations

In vivo treatment with interleukin 12 protects mice from immune abnormalities observed during murine acquired immunodeficiency syndrome (MAIDS).

1994 • 106 citations

Local production of tumor necrosis factor encoded by recombinant vaccinia virus is effective in controlling viral replication in vivo.

1991 • 93 citations

IFN-gamma receptor-deficient mice generate antiviral Th1-characteristic cytokine profiles but altered antibody responses.

1994 • 93 citations

Gamma interferon is not essential for recovery from acute infection with murine gammaherpesvirus 68

1997 • 83 citations

IL-12 promotes enhanced recovery from vesicular stomatitis virus infection of the central nervous system.

1995 • 82 citations

Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4

1995 • 66 citations

The Role of IL-10 in Mouse Hepatitis Virus-Induced Demyelinating Encephalomyelitis

1998 • 60 citations

The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon

1995 • 59 citations

Effects of virally expressed interleukin-10 on vaccinia virus infection in mice

1993 • 56 citations

CD40 ligand has potent antiviral activity

1995 • 48 citations

Different rules govern help for cytotoxic T cells and B cells

1978 • 48 citations

Nitric Oxide Production Is Increased during Murine Vaccinia Virus Infection, but May Not Be Essential for Virus Clearance

1996 • 43 citations

In vivo depletion of interferon-gamma leads to susceptibility of A/J mice to mouse hepatitis virus 3 infection

1992 • 32 citations

A recombinant vaccinia virus encoding inducible nitric oxide synthase is attenuated in vivo

1996 • 19 citations

Modification of the Sendai virus-specific antibody and CD8+ T-cell responses in mice homozygous for disruption of the interleukin-4 gene

1997 • 18 citations