The Role of IL-10 in Mouse Hepatitis Virus-Induced Demyelinating Encephalomyelitis

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Interleukin-10

1993 • 1,820 citations

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.

1996 • 920 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis.

1996 • 642 citations

Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery.

1992 • 627 citations

IL-10: a novel cytotoxic T cell differentiation factor.

1991 • 391 citations

Interleukin‐10 prevents experimental allergic encephalomyelitis in rats

1994 • 377 citations

IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi.

1997 • 350 citations

Interleukin‐4 and interleukin‐10 synergize to inhibit cell‐mediated immunity in vivo

1993 • 341 citations

Pathogenesis of Demyelination Induced by a Mouse Hepatitis

1973 • 340 citations

Functions of IL-4 and Control of Its Expression

2017 • 337 citations

Review: cytokines and the pathogenesis of multiple sclerosis

1996 • 331 citations

Pathogenicity of antigenic variants of murine coronavirus JHM selected with monoclonal antibodies

1986 • 315 citations

Functions of IL-4 and Control of Its Expression

1997 • 290 citations

Correlation of interleukin-1β and cachectin concentrations in cerebrospinal fluid and outcome from bacterial meningitis

1989 • 278 citations

Local Delivery of Interleukin 4 by Retrovirus-Transduced T Lymphocytes Ameliorates Experimental Autoimmune Encephalomyelitis

1997 • 264 citations

Retinoid treatment of experimental allergic encephalomyelitis. IL-4 production correlates with improved disease course.

1995 • 249 citations

Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses.

1995 • 243 citations

Neuroprotective role of IL-4 against activated microglia.

1993 • 214 citations

Self-antigen-induced Th2 responses in experimental allergic encephalomyelitis (EAE)-resistant mice. Th2-mediated suppression of autoimmune disease.

1995 • 203 citations

Both innate and acquired immunity to Listeria monocytogenes infection are increased in IL-10-deficient mice.

1997 • 202 citations

Regulation of cytolytic T-lymphocyte generation by B-cell stimulatory factor

1987 • 193 citations

Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4+ and CD8+ T cells

1990 • 189 citations

Cytokines in the generation of immune responses to, and resolution of, virus infection

1994 • 185 citations

Local nitric oxide production in viral and autoimmune diseases of the central nervous system.

1995 • 185 citations

Antigenic relationships of murine coronaviruses: Analysis using monoclonal antibodies to JHM (MHV-4) virus

1983 • 163 citations

Pathogenesis of mouse hepatitis virus-induced demyelination

1996 • 145 citations

Mouse hepatitis virus is cleared from the central nervous systems of mice lacking perforin-mediated cytolysis

1997 • 145 citations

Interleukin‐4 and interleukin‐10 synergize to inhibit cell‐mediated immunity in vivo

1993 • 142 citations

Interleukin‐4 and ‐10 exacerbate candidiasis in mice

1995 • 139 citations

Interleukin-4 causes delayed virus clearance in influenza virus-infected mice

1996 • 138 citations

Activation of Astrocytes in the Spinal Cord of Mice Chronically Infected with a Neurotropic Coronavirus

1995 • 128 citations

Mouse hepatitis virus-specific cytotoxic T lymphocytes protect from lethal infection without eliminating virus from the central nervous system

1995 • 119 citations

Gamma interferon is a major mediator of antiviral defense in experimental measles virus-induced encephalitis

1995 • 115 citations

Monoclonal antibodies to the matrix (El) glycoprotein of mouse hepatitis virus protect mice from encephalitis

1989 • 113 citations

Cytokines in relapsing experimental autoimmune encephalomyelitis in DA rats: persistent mRNA expression of proinflammatory cytokines and absent expression of interleukin-10 and transforming growth factor-β

1996 • 112 citations

Murine coronavirus infection: a paradigm for virus-induced demyelinating disease

1997 • 109 citations

Disassociation between the in vitro and in vivo effects of nitric oxide on a neurotropic murine coronavirus

1997 • 105 citations

Expression pattern and cellular origin of cytokines in the normal and Toxoplasma gondii-infected murine brain.

1997 • 102 citations

Evolution of Mouse Hepatitis Virus (MHV) during Chronic Infection: Quasispecies Nature of the Persisting MHV RNA

1995 • 90 citations

Inhibition of nitric oxide synthesis increases mortality in Sindbis virus encephalitis

1996 • 88 citations

In vivo effects of coronavirus-specific T cell clones: DTH inducer cells prevent a lethal infection but do not inhibit virus replication.

1986 • 86 citations

Characterization of brain-infiltrating mononuclear cells during infection with mouse hepatitis virus strain JHM

1991 • 83 citations

Kinetics of Cytokine mRNA Expression in the Central Nervous System Following Lethal and Nonlethal Coronavirus-Induced Acute Encephalomyelitis

1997 • 79 citations

Production of mice from a lethal coronavirus infection in the central nervous system by adoptive transfer of virus-specific T cell clones

1991 • 77 citations

Nucleocapsid or spike protein-specific CD4+ T lymphocytes protect against coronavirus-induced encephalomyelitis in the absence of CD8+ T cells.

1991 • 76 citations

Regulation of brain-derived T cells during acute central nervous system inflammation.

1997 • 74 citations

Expression of the inducible nitric oxide synthase. Correlation with neuropathology and clinical features in mice with lymphocytic choriomeningitis.

1994 • 67 citations

Effects of virally expressed interleukin-10 on vaccinia virus infection in mice

1993 • 56 citations

The astrocyte is a target cell in mice persistently infected with mouse hepatitis virus, strain JHM

1987 • 55 citations

Intrathecal synthesis of interleukin-10 (IL-10) in viral and inflammatory diseases of the central nervous system

1994 • 49 citations

Tumor necrosis factor expression during mouse hepatitis virus-induced demyelinating encephalomyelitis

1995 • 48 citations

Population dynamics of lymphocyte subsets in the central nervous system of rats with different susceptibility to coronavirus-induced demyelinating encephalitis.

1991 • 37 citations

Nitric oxide synthase Type II expression by different cell types in MHV-JHM encephalitis suggests distinct roles for nitric oxide in acute versus persistent virus infection

1997 • 36 citations

Role of apoptosis in the regulation of virus‐induced T cell responses, immune suppression, and memory

1995 • 34 citations

Virus-specific T cells in the central nervous system following infection with an avirulent neurotropic mouse hepatitis virus.

1992 • 8 citations