Overexpression of interleukin-4 delays virus clearance in mice infected with respiratory syncytial virus

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

RESPIRATORY SYNCYTIAL VIRUS DISEASE IN INFANTS DESPITE PRIOR ADMINISTRATION OF ANTIGENIC INACTIVATED VACCINE12

1969 • 1,921 citations

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

Lymphokine Production by Human T Cells in Disease States

1994 • 1,351 citations

Disruption of the murine IL-4 gene blocks Th2 cytokine responses

1993 • 1,197 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

AN EPIDEMIOLOGIC STUDY OF ALTERED CLINICAL REACTIVITY TO RESPIRATORY SYNCYTIAL (RS) VIRUS INFECTION IN CHILDREN PREVIOUSLY VACCINATED WITH AN INACTIVATED RS VIRUS VACCINE

1969 • 1,010 citations

New Concepts about the Mast Cell

1993 • 1,009 citations

Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine.

1991 • 617 citations

The Development of Respiratory Syncytial Virus-Specific IgE and the Release of Histamine in Nasopharyngeal Secretions after Infection

1981 • 532 citations

Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals.

1993 • 484 citations

T cell genetic background determines default T helper phenotype development in vitro.

1995 • 466 citations

IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice

1990 • 410 citations

Tumor necrosis factor combines with IL-4 or IFN-gamma to selectively enhance endothelial cell adhesiveness for T cells. The contribution of vascular cell adhesion molecule-1-dependent and -independent binding mechanisms.

1991 • 398 citations

Priming immunization determines T helper cytokine mRNA expression patterns in lungs of mice challenged with respiratory syncytial virus.

1993 • 397 citations

Primary respiratory syncytial virus infection in mice

1988 • 381 citations

Defining protective responses to pathogens: cytokine profiles in leprosy lesions

1991 • 375 citations

Distinct types of lung disease caused by functional subsets of antiviral T cells.

1994 • 318 citations

Th1 and Th2 cytokine secretion patterns in murine candidiasis: association of Th1 responses with acquired resistance

1991 • 195 citations

The relationship of RSV‐specific immunoglobulin E antibody responses in infancy, recurrent wheezing, and pulmonary function at age 7–8 years.

1993 • 170 citations

Clearance of persistent respiratory syncytial virus infections in immunodeficient mice following transfer of primed T cells.

1987 • 157 citations

Anti-IL-4 treatment at immunization modulates cytokine expression, reduces illness, and increases cytotoxic T lymphocyte activity in mice challenged with respiratory syncytial virus.

1994 • 145 citations

Interleukin-4 causes delayed virus clearance in influenza virus-infected mice

1996 • 138 citations

Interleukin-4 mediates down regulation of antiviral cytokine expression and cytotoxic T-lymphocyte responses and exacerbates vaccinia virus infection in vivo

1996 • 132 citations

Cytotoxic T-cell response to respiratory syncytial virus in mice

1985 • 105 citations

Humoral immune functions in IL-4 transgenic mice.

1991 • 86 citations

Cell-Mediated Immune Response to Schistosomiasis

1990 • 63 citations

Reinfection of mice with respiratory syncytial virus

1991 • 63 citations

Immunoprophylaxis and Immunotherapy of Respiratory Syncytial Virus–Infected Mice with Respiratory Syncytial Virus–Specific Immune Serum

1993 • 52 citations

Determinants and kinetics of cytokine expression patterns in lungs of vaccinated mice challenged with respiratory syncytial virus

1997 • 26 citations