Early modifications in the expression of mitogen-activated protein kinase (MAPK/ERK), stress-activated kinases SAPK/JNK and p38, and their phosphorylated substrates following focal cerebral ischemia

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals

1999 • 2,076 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development

1998 • 1,551 citations

Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

1996 • 1,519 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway

1995 • 1,453 citations

Selective interaction of JNK protein kinase isoforms with transcription factors.

1996 • 1,333 citations

Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity

1995 • 1,287 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase

1996 • 1,253 citations

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1997 • 1,229 citations

The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory

2001 • 1,140 citations

Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation

1996 • 1,099 citations

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activationofCREB

1998 • 975 citations

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.

1994 • 820 citations

A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death

1995 • 800 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation.

1995 • 667 citations

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.

1994 • 639 citations

FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2.

1996 • 633 citations

ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents.

1995 • 603 citations

Neuroprotection by Brain-derived Neurotrophic Factor Is Mediated by Extracellular Signal-regulated Kinase and Phosphatidylinositol 3-Kinase

1999 • 561 citations

Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.

1995 • 535 citations

Selective Activation of p38 Mitogen-activated Protein (MAP) Kinase Isoforms by the MAP Kinase Kinases MKK3 and MKK6

1998 • 531 citations

The c-Jun transcription factor – bipotential mediator of neuronal death, survival and regeneration

1997 • 520 citations

Is CREB a key to neuronal survival?

2000 • 516 citations

The Regulation of Anoikis: MEKK-1 Activation Requires Cleavage by Caspases

1997 • 507 citations

c-Jun Can Recruit JNK to Phosphorylate Dimerization Partners via Specific Docking Interactions

1996 • 495 citations

JNK and p38 stresskinases — degenerative effectors of signal-transduction-cascades in the nervous system

2000 • 490 citations

Regulation and function of the JNK subgroup of MAP kinases

1997 • 484 citations

Ras Enhances Myc Protein Stability

1999 • 452 citations

Mechanisms of apoptosis by c-Myc

1999 • 430 citations

The Ras branch of small Gtpases: Ras family members don’t fall far from the tree

2000 • 408 citations

Phosphorylation of c-Jun Is Necessary for Apoptosis Induced by Survival Signal Withdrawal in Cerebellar Granule Neurons

1998 • 365 citations

Role of Mitogen- and Stress-Activated Kinases in Ischemic Injury

2002 • 363 citations

Direct Activation of Mitochondrial Apoptosis Machinery by c-Jun N-terminal Kinase in Adult Cardiac Myocytes

2002 • 342 citations

Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation

1998 • 341 citations

Lasting N-Terminal Phosphorylation of c-Jun and Activation of c-Jun N-Terminal Kinases after Neuronal Injury

1998 • 330 citations

Motoneuron Apoptosis Is Blocked by CEP-1347 (KT 7515), a Novel Inhibitor of the JNK Signaling Pathway

1998 • 291 citations

A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication

2001 • 290 citations

Role of the Jun Kinase Pathway in the Regulation of c-Jun Expression and Apoptosis in Sympathetic Neurons

1998 • 284 citations

Differential activation of MAPK/ERK and p38/SAPK in neurones and glia following focal cerebral ischaemia in the rat

2000 • 269 citations

CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons In vivo.

1999 • 264 citations

Activation of Mitogen-Activated Protein Kinases after Transient Forebrain Ischemia in Gerbil Hippocampus

2000 • 252 citations

Role of MAP kinase in neurons

1998 • 250 citations

Long-term increase in the levels of c-jun mRNA and jun protein-like immunoreactivity in motor and sensory neurons following axon damage

1991 • 249 citations

Hydrogen Peroxide Activation of Multiple Mitogen‐Activated Protein Kinases in an Oligodendrocyte Cell Line

1999 • 248 citations

Peripheral Axotomy Induces Long-Term c-Jun Amino-Terminal Kinase-1 Activation and Activator Protein-1 Binding Activity by c-Jun and junD in Adult Rat Dorsal Root GangliaIn Vivo

1998 • 236 citations

p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient

1996 • 217 citations

A GTPase Controlling Nuclear Trafficking: Running the Right Way or Walking RANdomly?

1996 • 211 citations

Ca²⁺-Permeable AMPA Receptors Induce Phosphorylation of cAMP Response Element-Binding Protein through a Phosphatidylinositol 3-Kinase-Dependent Stimulation of the Mitogen-Activated Protein Kinase Signaling Cascade in Neurons

1999 • 197 citations

Role of p38 Mitogen-Activated Protein Kinase in Axotomy-Induced Apoptosis of Rat Retinal Ganglion Cells

2000 • 197 citations

Antiapoptotic role of the p38 mitogen-activated protein kinase–myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation

2000 • 193 citations

CREB Phosphorylation Promotes Nerve Cell Survival

1999 • 189 citations

Inhibition of v-raf-dependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-activated protein kinase Erk2.

1994 • 186 citations

Midkine Inhibits Caspase‐Dependent Apoptosis via the Activation of Mitogen‐Activated Protein Kinase and Phosphatidylinositol 3‐Kinase in Cultured Neurons

1999 • 184 citations

The role of inducible transcription factors in apoptotic nerve cell death

1995 • 184 citations

Selective Activation of c-Jun Kinase Mitogen-activated Protein Kinase by CD40 on Human B Cells

1995 • 172 citations

Differential Patterns of ERK and STAT3 Phosphorylation after Sciatic Nerve Transection in the Rat

2000 • 171 citations

The proto-oncogene c-myc and apoptosis

1998 • 160 citations

Transactivation of gene expression by Myc is inhibited by mutation at the phosphorylation sites Thr-58 and Ser-62.

1993 • 160 citations

Activation of p38^MAPK in Microglia After Ischemia

1998 • 152 citations

Tyrosine Phosphorylation and Activation of Mitogen‐ Activated Protein Kinase in the Rat Brain Following Transient Cerebral Ischemia

1994 • 147 citations

MPP+ increases α-synuclein expression and ERK/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells

2002 • 143 citations

Activation of the extracellular signal-regulated protein kinase cascade in the hippocampal CA1 region in a rat model of global cerebral ischemic preconditioning

1999 • 137 citations

UVB-mediated activation of p38 mitogen-activated protein kinase enhances resistance of normal human keratinocytes to apoptosis by stabilizing cytoplasmic p53

2002 • 125 citations

Mitogen-Activated Protein Kinase Pathway Mediates Peroxynitrite-Induced Apoptosis in Human Dopaminergic Neuroblastoma SH-SY5Y Cells

1999 • 124 citations

Activity and expression of JNK1, p38 and ERK kinases, c-Jun N-terminal phosphorylation, and c-jun promoter binding in the adult rat brain following kainate-induced seizures

1999 • 123 citations

The role of Jun transcription factor expression and phosphorylation in neuronal differentiation, neuronal cell death, and plastic adaptationsin vivo

1994 • 123 citations

Activation of Mitogen-Activated Protein Kinases After Permanent Cerebral Artery Occlusion in Mouse Brain

2000 • 121 citations

The role of the cyclic AMP-responsive element binding protein (CREB) in hypoxic-ischemic brain damage and repair

1996 • 119 citations

Selective c‐JUN Expression in CA1 Neurons of the Gerbil Hippocampus during and after Acquisition of an Ischemia‐Tolerant State

1995 • 115 citations

Expression of JUN, KROX, and CREB transcription factors in goldfish and rat retinal ganglion cells following optic nerve lesion is related to axonal sprouting

1993 • 113 citations

Human immunodeficiency virus type 1 and its coat protein gp 120 induce apoptosis and activate JNK and ERK mitogen‐activated protein kinases in human neurons

1997 • 113 citations

Alteration of MAP Kinase Pathways after Transient Forebrain Ischemia

2000 • 108 citations

Delayed neuronal cell death in the rat hippocampus is mediated by the mitogen-activated protein kinase signal transduction pathway

1999 • 101 citations

Persistent phosphorylation of cyclic amp responsive element-binding protein and activating transcription factor-2 transcription factors following transient cerebral ischemia in rat brain

1999 • 100 citations

Specific Activation of a c-Jun NH2-terminal Kinase Isoform and Induction of Neurite Outgrowth in PC-12 Cells by Staurosporine

1997 • 96 citations

Expression of immediate early gene proteins following axotomy and inhibition of axonal transport in the rat central nervous system

1993 • 94 citations

Immunoreactive Akt, PI3-K and ERK protein kinase expression in ischemic rat brain

1999 • 91 citations

Expression of c‐fos, c‐jun, and N‐terminal kinase (JNK) in a Development Model of Induced Apoptotic Death in Neurons of the Substantia Nigra

1999 • 86 citations

Hippocampal Myc and p53 expression following transient global ischemia

1998 • 85 citations

The Kinetic Mechanism of the Dual Phosphorylation of the ATF2 Transcription Factor by p38 Mitogen-activated Protein (MAP) Kinase α

2001 • 76 citations

Active, phosphorylation-dependent MAP kinases, MAPK/ERK, SAPK/JNK and p38, and specific transcription factor substrates are differentially expressed following systemic administration of kainic acid to the adult rat

2002 • 71 citations

c-Jun promotes neurite outgrowth and survival in PC12 cells

2000 • 70 citations

DNA fragmentation in ischemic core and penumbra in focal cerebral ischemia in rats

2001 • 64 citations

Phosphorylation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase after transient forebrain ischemia in mice

2000 • 59 citations

c-Jun N-terminal kinase activation in hippocampal CA1 region was involved in ischemic injury

2001 • 56 citations

Differential expression of active, phosphorylation-dependent MAP kinases, MAPK/ERK, SAPK/JNK and p38, and specific transcription factor substrates following quinolinic acid excitotoxicity in the rat

2001 • 52 citations

Chapter 15 Expression of c-Jun and JunD transcription factors represent specific changes in neuronal gene expression following axotomy

1994 • 49 citations

Extracellular signal-regulated kinase 1/2 activation in hippocampus after cerebral ischemia may not interfere with postischemic cell death

2001 • 46 citations

ATF-2 phosphorylation in apoptotic neuronal death

1998 • 46 citations

Kainic acid-induced excitotoxicity is associated with a complex c-Fos and c-Jun response which does not preclude either cell death or survival.

1997 • 42 citations

Up-regulation of c-myc gene expression following focal ischemia in the rat brain

1996 • 35 citations

Striatal Infarction in the Rat Causes a Transient Reduction of Tyrosine Hydroxylase Immunoreactivity in the Ipsilateral Substantia Nigra

1997 • 31 citations

Induction of c-Jun and Suppression of CREB Transcription Factor Proteins in Axotomized Neurons of Substantia Nigra and Covariation with Tyrosine Hydroxylase

1994 • 27 citations

Tumour necrosis factor-induced activation of c-Jun N-terminal kinase is sensitive to caspase-dependent modulation while activation of mitogen-activated protein kinase (MAPK) or p38 MAPK is not

2002 • 22 citations

Up-regulation of Jun/AP-1 during differentiation of N1E-115 neuroblastoma cells.

1991 • 21 citations

Kainic acid—induced excitotoxicity is associated with a complex c‐Fos and c‐Jun response which does not preclude either cell death or survival

1997 • 2 citations