Back to search

Phosphorylation of c-Jun Is Necessary for Apoptosis Induced by Survival Signal Withdrawal in Cerebellar Granule Neurons

Data up to Jan 2025

Published1998
Citations365
References53

Total Citations Per Year

Abstract

References (53)

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Trophic factors and neuronal survival

1989 • 1,631 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Selective interaction of JNK protein kinase isoforms with transcription factors.

1996 • 1,333 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

1988 • 1,256 citations

Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element

1988 • 983 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

1993 • 886 citations

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.

1994 • 820 citations

A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death

1995 • 800 citations

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

1991 • 800 citations

Activation of cAMP and mitogen responsive genes relies on a common nuclear factor

1994 • 730 citations

Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene

1992 • 724 citations

Neuronal regulation of astroglial morphology and proliferation in vitro.

1985 • 605 citations

ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents.

1995 • 603 citations

The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis

1993 • 586 citations

Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts

1988 • 578 citations

Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction.

1989 • 502 citations

A new group of conserved coactivators that increase the specificity of AP-1 transcription factors

1996 • 457 citations

Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis

1995 • 403 citations

Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein.

1993 • 380 citations

Molecular Mechanisms of Developmental Neuronal Death

1993 • 330 citations

Potassium Deprivation-Induced Apoptosis of Cerebellar Granule Neurons: A Sequential Requirement for New mRNA and Protein Synthesis, ICE-Like Protease Activity, and Reactive Oxygen Species

1996 • 324 citations

The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye.

1996 • 310 citations

Activation of the CED3/ICE-Related Protease CPP32 in Cerebellar Granule Neurons Undergoing Apoptosis But Not Necrosis

1997 • 284 citations

Cerebellar granule cell neurogenesis is regulated by cell-cell interactions in vitro

1991 • 246 citations

Metabolic and Genetic Analyses of Apoptosis in Potassium/Serum-Deprived Rat Cerebellar Granule Cells

1996 • 216 citations

Variations in Jun and Fos protein expression and AP-1 activity in cycling, resting and stimulated fibroblasts

1997 • 139 citations

A timetable of events during programmed cell death induced by trophic factor withdrawal from neuronal PC12 cells

1995 • 138 citations

Programmed cell death in the absence of c-Fos and c-Jun

1996 • 127 citations

Intramolecular signal transduction in c-Jun.

1995 • 127 citations

JUN cooperates with the ETS domain protein pointed to induce photoreceptor R7 fate in the Drosophila eye

1995 • 118 citations

Inhibition of protein synthesis prevents cell death in sensory and parasympathetic neurons deprived of neurotrophic factor in vitro

1990 • 103 citations

Binding of promoter-associated AP-1 is not altered during induction and subsequent repression of the c-jun promoter by TPA and UV irradiation

1994 • 97 citations

Drosophila Jun mediates Ras-dependent photoreceptor determination

1994 • 94 citations

Neither erk nor jnk/sapk map kinase subtypes are essential for histone h3/hmg-14 phosphorylation or c-fos and c-jun induction

1995 • 74 citations

Motoneurons deprived of trophic support in vitro require new gene expression to undergo programmed cell death

1994 • 68 citations

Apoptosis in Cerebellar Granule Neurones: Involvement of Interleukin‐1β Converting Enzyme‐Like Proteases

1997 • 63 citations

Phosphorylation of Drosophila Jun by the MAP kinase rolled regulates photoreceptor differentiation.

1996 • 57 citations

In vitro transforming capacities of mouse c-jun:junD chimeric genes.

1993 • 9 citations

Cited By (0)

Loading...
Phosphorylation of c-Jun Is Necessary for Apoptosis Induced by Survival Signal Withdrawal… (1998) – Journal of Neuroscience | Metascience Observatory Explorer