Enhancement of T cell-independent immune responses in vivo by CD40 antibodies

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

T Cell-Independent Antigens Type 2

1995 • 798 citations

Mice deficient for the CD40 ligand

1994 • 753 citations

Cutting Edge: Heat Shock Protein (HSP) 60 Activates the Innate Immune Response: CD14 Is an Essential Receptor for HSP60 Activation of Mononuclear Cells

2000 • 561 citations

Humoral immune responses in CD40 ligand-deficient mice.

1994 • 541 citations

Mechanism and Regulation of Immunoglobulin Isotype Switching

1993 • 516 citations

CD40 Ligand-Dependent T Cell Activation: Requirement of B7-CD28 Signaling Through CD40

1996 • 421 citations

Perspective: Hypothesis: Serum IgG Antibody Is Sufficient to Confer Protection against Infectious Diseases by Inactivating the Inoculum

1995 • 386 citations

Antibody Response to Pneumococcal Vaccination in Children Younger than Five Years of Age

1983 • 384 citations

Streptococcus pneumoniae: virulence factors, pathogenesis, and vaccines

1995 • 357 citations

CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.

1994 • 245 citations

Assessment of the Antibody Response to Pneumococcal Vaccine in High-Risk Populations

1981 • 202 citations

Serum antibodies after vaccination with Haemophilus influenzae type b capsular polysaccharide and responses to reimmunization: no evidence of immunologic tolerance or memory.

1984 • 160 citations

Streptococcus pneumoniae: virulence factors, pathogenesis, and vaccines.

1995 • 152 citations

Monoclonal antibodies to murine CD40 define two distinct functional epitopes

1994 • 152 citations

Induction of B cell costimulatory function by recombinant murine CD40 ligand

1994 • 148 citations

Serum Antibodies After Vaccination with Haemophilus influenzae Type b Capsular Polysaccharide and Responses to Reimmunization: No Evidence of Immunologic Tolerance or Memory

1984 • 124 citations

CD40 ligand is a T cell growth factor

1993 • 123 citations

CBA/N Immune Defective Mice; Evidence for the Failure of a B Cell Subpopulation to be Expressed

1982 • 121 citations

Effect of Human Immunodeficiency Virus Type 1 Infection on the Antibody Response to a Glycoprotein Conjugate Pneumococcal Vaccine: Results from a Randomized Trial

1996 • 115 citations

Induction of germ-line gamma 1 and epsilon Ig gene expression in murine B cells. IL-4 and the CD40 ligand-CD40 interaction provide distinct but synergistic signals.

1995 • 113 citations

CD38 unresponsiveness of xid B cells implicates Bruton's tyrosine kinase (btk) as a regulator of CD38 induced signal transduction

1995 • 87 citations

Antibody Class and Subclass Responses to Pneumococcal Polysaccharides following Immunization of Human Immunodeficiency Virus-Infected Patients

1995 • 81 citations

Recombinant CD40 ligand exerts potent biologic effects on T cells.

1994 • 77 citations

Immunogenicity and safety of a 23-valent pneumococcal polysaccharide vaccine in healthy children and in children at increased risk of pneumococcal infection

1995 • 73 citations

A modified enzyme-linked immunosorbent assay for measuring type-specific anti-pneumococcal capsular polysaccharide antibodies

1993 • 60 citations

B cells from CBA/N mice do not proliferate following ligation of CD40

1994 • 55 citations

T helper cell membranes promote IL-4-independent expression of germ-line C gamma 1 transcripts in B cells.

1992 • 44 citations

CD40 signaling induces interleukin‐4‐independent IgE switching in vivo

1996 • 31 citations

Responsiveness of infants to capsular polysaccharides

1996 • 15 citations