A Prominent Role for Airway Epithelial NF-κB Activation in Lipopolysaccharide-Induced Airway Inflammation

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

Activators and Target Genes of Rel/NF-кB Transcription Factors

2003 • 3,164 citations

Therapeutic potential of inhibition of the NF-κB pathway in the treatment of inflammation and cancer

2001 • 1,548 citations

NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1

1999 • 1,282 citations

Control of apoptosis by Rel/NF-κB transcription factors

1999 • 1,204 citations

Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B.

1990 • 900 citations

Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor β1

2001 • 896 citations

Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages.

1990 • 826 citations

Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity

1991 • 746 citations

Introns increase transcriptional efficiency in transgenic mice.

1988 • 733 citations

Inflammatory mediators of asthma: an update.

1998 • 719 citations

New Insights into the Role of Nuclear Factor-κB, a Ubiquitous Transcription Factor in the Initiation of Diseases

1999 • 717 citations

Recent advances torwards understanding redox mechanisms in the activation of nuclear factor κb

2000 • 674 citations

Hypoxia Induces Cyclooxygenase-2 via the NF-κB p65 Transcription Factor in Human Vascular Endothelial Cells

1997 • 673 citations

Synergistic upregulation of metalloproteinase‐9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF‐κB

1998 • 500 citations

A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation

2001 • 497 citations

Activation and Localization of Transcription Factor, Nuclear Factor- κ B, in Asthma

1998 • 422 citations

Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-κB subunit

1992 • 399 citations

Nuclear Factor Kappa B: Important Transcription Factor and Therapeutic Target

1998 • 366 citations

Nuclear uptake control of NF-kappa B by MAD-3, an I kappa B protein present in the nucleus.

1993 • 330 citations

The Role of Nuclear Factor-κ B in Pulmonary Diseases

2000 • 315 citations

CD14-dependent Lipopolysaccharide-induced β-Defensin-2 Expression in Human Tracheobronchial Epithelium

2000 • 309 citations

Macrophage Inflammatory Proteins: Biology and Role in Pulmonary Inflammation

1994 • 307 citations

Essential Role of Nuclear Factor κB in the Induction of Eosinophilia in Allergic Airway Inflammation

1998 • 304 citations

H2O2 and Tumor Necrosis Factor-α Activate Intercellular Adhesion Molecule 1 (ICAM-1) Gene Transcription through Distinct cis-Regulatory Elements within the ICAM-1 Promoter

1995 • 284 citations

Targeted Mutation of TNF Receptor I Rescues the RelA-Deficient Mouse and Reveals a Critical Role for NF-κB in Leukocyte Recruitment

2001 • 260 citations

Genomic cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1 alpha, and MIP-1 beta, members of the chemokine superfamily of proinflammatory cytokines.

1993 • 253 citations

Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase.

1990 • 235 citations

Epithelial cells as regulators of airway inflammation

1998 • 234 citations

Regulation of Tumor Necrosis Factor Alpha Transcription in Macrophages: Involvement of Four κΒ-Like Motifs and of Constitutive and Inducible Forms of NF-κB

1990 • 230 citations

NF-kB: a pivotal role in asthma and a new target for therapy

1997 • 218 citations

Triggering of the Human Interleukin-6 Gene by Interferon-γ and Tumor Necrosis Factor-α in Monocytic Cells Involves Cooperation between Interferon Regulatory Factor-1, NFκB, and Sp1 Transcription Factors

1995 • 213 citations

Inhibition of NF?B in activated rat hepatic stellate cells by proteasome inhibitors and an I?B super-repressor

1998 • 178 citations

Requirement for nuclear factor (NF)-kappa B p65 and NF-interleukin-6 binding elements in the tumor necrosis factor response region of the granulocyte colony-stimulating factor promoter

1994 • 157 citations

Cloning, expression, and functional characterization of rat MIP-2: a neutrophil chemoattractant and epithelial cell mitogen

1995 • 152 citations

Airway epithelium as an effector of inflammation: molecular regulation of secondary mediators

1997 • 150 citations

Rapid Activation of Nuclear Factor-κB in Airway Epithelium in a Murine Model of Allergic Airway Inflammation

2002 • 149 citations

Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes.

1997 • 147 citations

cis-acting elements that confer lung epithelial cell expression of the CC10 gene.

1992 • 144 citations

Genistein Prevents Nuclear Factor-Kappa B Activation and Acute Lung Injury Induced by Lipopolysaccharide

2001 • 142 citations

Enterochelin hydrolysis and iron metabolism in Escherichia coli

1971 • 137 citations

Multiorgan Nuclear Factor Kappa B Activation in a Transgenic Mouse Model of Systemic Inflammation

2000 • 135 citations

Effects of Budesonide and Formoterol on NF- κ B, Adhesion Molecules, and Cytokines in Asthma

2001 • 131 citations

NF-kappa B/Rel transcription factors: c-Rel promotes airway hyperresponsiveness and allergic pulmonary inflammation.

1999 • 127 citations

Mechanisms of Persistent NF-κB Activity in the Bronchi of an Animal Model of Asthma

2000 • 127 citations

In Murine 3T3 Fibroblasts, Different Second Messenger Pathways Resulting in the Induction of NO Synthase II (iNOS) Converge in the Activation of Transcription Factor NF-κB

1996 • 127 citations

Macrophages Are Necessary for Maximal Nuclear Factor- κ B Activation in Response to Endotoxin

2002 • 125 citations

Correlation between Nuclear Factor- κ B Activity in Bronchial Brushing Samples and Lung Dysfunction in an Animal Model of Asthma

2000 • 122 citations

NF-κB/Rel Transcription Factors: c-Rel Promotes Airway Hyperresponsiveness and Allergic Pulmonary Inflammation

1999 • 116 citations

Synergistic Activation of Interleukin-8 Gene Transcription by All-trans-retinoic Acid and Tumor Necrosis Factor-α Involves the Transcription Factor NF-κB

1996 • 110 citations

The involvement of matrix metalloproteinase‐9 in airway inflammation of patients with acute asthma

2001 • 102 citations

Asbestos causes translocation of p65 protein and increases NF-kappa B DNA binding activity in rat lung epithelial and pleural mesothelial cells.

1997 • 98 citations

Selective IκB Kinase Expression in Airway Epithelium Generates Neutrophilic Lung Inflammation

2003 • 97 citations

Effects of Inhaled Corticosteroid Therapy on Expression and DNA-Binding Activity of Nuclear Factor κ B in Asthma

2000 • 97 citations

Genomic Organization, Sequence, and Transcriptional Regulation of the Human Eotaxin Gene

1997 • 85 citations

Modulation of Proinflammatory Cytokines by Nitric Oxide in Murine Acute Lung Injury

1999 • 80 citations

The Allergen Der p1 Induces NF-kB Activation through Interference with IkBα Function in Asthmatic Bronchial Epithelial Cells

1997 • 79 citations

Proliferation and activation of bronchial epithelial cells in corticosteroid-dependent asthma

2001 • 78 citations

IL-11 Selectively Inhibits Aeroallergen-Induced Pulmonary Eosinophilia and Th2 Cytokine Production

2000 • 64 citations

Volume-dependent taurine release from cultured astrocytes requires permissive [Ca²⁺]_iand calmodulin

1999 • 63 citations

Anti-inflammatory gene therapy directed at the airway epithelium

2000 • 61 citations

The bronchial epithelium in asthma--much more than a passive barrier.

2001 • 49 citations

Differential NF-κB activation after intratracheal endotoxin

1999 • 47 citations

Immunohistochemical localization of mouse Clara cell 10-KD protein using antibodies raised against the recombinant protein.

1996 • 37 citations

Functions of IκB Proteins in Inflammatory Responses toEscherichia coliLPS in Mouse Lungs

2002 • 36 citations

Activation of NF-kappa B in bronchial epithelial cells from children with asthma.

2001 • 30 citations

Quantitative Time-Course Profiles of Bronchoalveolar Lavage Cells Following Intratracheal Instillation of Lipopolysaccharide in Mice.

1997 • 27 citations

Measurement of oxidant-induced signal transduction proteins using cell imaging

1999 • 16 citations

Requirement for nuclear factor (NF)-kappa B p65 and NF-interleukin-6 binding elements in the tumor necrosis factor response region of the granulocyte colony-stimulating factor promoter

1994 • 8 citations