Effects of Inhaled Corticosteroid Therapy on Expression and DNA-Binding Activity of Nuclear Factor κ B in Asthma

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.

1994 • 2,216 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.

1989 • 1,660 citations

Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

1992 • 1,421 citations

The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system

1988 • 1,235 citations

Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor.

1994 • 1,057 citations

Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma.

1991 • 841 citations

Characterization of Mechanisms Involved in Transrepression of NF-κB by Activated Glucocorticoid Receptors

1995 • 815 citations

Anti-inflammatory actions of steroids: molecular mechanisms

1993 • 740 citations

Inhaled Glucocorticoids for Asthma

1995 • 640 citations

Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop.

1993 • 600 citations

A comparative study of the effects of an inhaled corticosteroid, budesonide, and a β2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: A randomized, double-blind, parallel-group controlled trial

1992 • 595 citations

Activation and Localization of Transcription Factor, Nuclear Factor- κ B, in Asthma

1998 • 422 citations

Rapid and quantitative preparation of cytoplasmic RNA from small numbers of cells

1988 • 406 citations

Dexamethasone inhibition of interleukin 1 beta production by human monocytes. Posttranscriptional mechanisms.

1988 • 317 citations

Prednisolone Treatment in Asthma Is Associated with Modulation of Bronchoalveolar Lavage Cell Interleukin-4, Interleukin-5, and Interferon-γ Cytokine Gene Expression

1993 • 307 citations

Rhinovirus stimulation of interleukin-6 in vivo and in vitro. Evidence for nuclear factor kappa B-dependent transcriptional activation.

1996 • 282 citations

Prednisolone treatment in asthma. Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa.

1996 • 266 citations

Oxidative Stress Induces NFκB DNA Binding and Inducible NOS mRNA in Human Epithelial Cells

1994 • 263 citations

Genomic cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1 alpha, and MIP-1 beta, members of the chemokine superfamily of proinflammatory cytokines.

1993 • 253 citations

Detection of GM-CSF in Asthmatic Bronchial Epithelium and Decrease by Inhaled Corticosteroids

1993 • 208 citations

Glucocorticoid-mediated Repression of NFκB Activity in Endothelial Cells Does Not Involve Induction of IκBα Synthesis

1996 • 204 citations

TNFα mRNA expression in allergic inflammation

1991 • 199 citations

Expression of RANTES by human bronchial epithelial cells in vitro and in vivo and the effect of corticosteroids.

1996 • 133 citations

Expression of interleukin-1 beta (IL-1beta) and interleukin-1 receptor antagonist (IL-1ra) on asthmatic bronchial epithelium.

1996 • 131 citations

Effects of glucocorticoids on transcription factor activation in human peripheral blood mononuclear cells

1995 • 128 citations

Inhibition of interleukin-5 gene expression by dexamethasone.

1992 • 105 citations

Inhibition of interleukin-8 expression by dexamethasone in human cultured airway epithelial cells.

1994 • 100 citations

Effect of dexamethasone on interleukin‐1β‐(IL‐1β)‐induced nuclear factor‐κB (NF‐κB) and κB‐dependent transcription in epithelial cells

1998 • 100 citations

c-fos Proto-oncogene Expression in Bronchial Biopsies of Asthmatics

1992 • 89 citations

Expression of RANTES in human airway epithelial cells: effect of corticosteroids and interleukin‐4, ‐10 and ‐13

1996 • 87 citations

Identification of a novel regulatory region critical for expression of the RANTES chemokine in activated T lymphocytes.

1996 • 85 citations

The effects of glucocorticoids on phorbol ester and cytokine stimulated transcription factor activation in human lung

1994 • 85 citations

Inhaled beclomethasone dipropionate downregulates airway lymphocyte activation in atopic asthma.

1994 • 83 citations

Effects of dexamethasone on cytokine and phorbol ester stimulated c-Fos and c-Jun DNA binding and gene expression in human lung

1994 • 50 citations

Dexamethasone potently enhances phorbol ester-induced IL-1beta gene expression and nuclear factor NF-kappaB activation.

1997 • 38 citations

Dexamethasone inhibits ozone‐induced gene expression of macrophage inflammatory protein‐2 in rat lung

1995 • 32 citations

Identification of Signal-induced IκB-α Kinases in Human Endothelial Cells

1996 • 25 citations

Glucocorticoids decrease c-fos expression in human nasal polyps in vivo

1998 • 19 citations

PREDNISOLONE TREATMENT IN ASTHMA IS ASSOCIATED WITH MODULATION OF BRONCHOALVEOLAR LAVAGE CELL IL-4, IL-5 AND IFN-GAMMA CYTOKINE GENE EXPRESSION

1993 • 16 citations