Structure and catalytic function of nucleases

Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP

1985 • 855 citations

SELF-SPLICING OF GROUP I INTRONS

1990 • 852 citations

Molecular Architecture and Biological Reactions

1946 • 835 citations

Pseudo-rotation in the hydrolysis of phosphate esters

1968 • 763 citations

Origins and Evolutionary Relationships of Retroviruses

1989 • 581 citations

Structural studies of protein–nucleic acid interaction: the sources of sequence-specific binding

1990 • 508 citations

Enzymatic Catalysis and Transition-State Theory

1973 • 501 citations

Structure of Ribonuclease H Phased at 2 Å Resolution by MAD Analysis of the Selenomethionyl Protein

1990 • 475 citations

Conformational stability and activity of ribonuclease T1 with zero, one, and two intact disulfide bonds.

1988 • 445 citations

Conformational stability of globular proteins

1990 • 390 citations

Staphylococcal nuclease: Proposed mechanism of action based on structure of enzyme—thymidine 3′,5′-bisphosphate—calcium ion complex at 1.5-Å resolution

1979 • 375 citations

The guanosine binding site of the Tetrahymena ribozyme

1989 • 356 citations

Energetics of complementary side chain packing in a protein hydrophobic core

1989 • 346 citations

Genetic and Crystallographic Studies of the 3′,5′-Exonucleolytic Site of DNA Polymerase I

1988 • 344 citations

Cocrystal structure of an editing complex of Klenow fragment with DNA.

1988 • 324 citations

Specific protein-nucleic acid recognition in ribonuclease T1–2′-guanylic acid complex: an X-ray study

1982 • 272 citations

Crystallographic and biochemical investigation of the lead(II)-catalyzed hydrolysis of yeast phenylalanine tRNA

1985 • 260 citations

The crystal structure of the ternary complex of staphylococcal nuclease, Ca²⁺ and the inhibitor pdTp, refined at 1.65 Å

1989 • 258 citations

Barnase and barstar: two small proteins to fold and fit together

1989 • 222 citations

CRYSTALLINE DESOXYRIBONUCLEASE

1950 • 185 citations

Identification of the amino acid residues involved in an active site of Escherichia coli ribonuclease H by site-directed mutagenesis.

1990 • 176 citations

Active site of RNase: neutron diffraction study of a complex with uridine vanadate, a transition-state analog.

1983 • 157 citations

Stereochemistry of RNA Cleavage by the Tetrahymena Ribozyme and Evidence that the Chemical Step Is Not Rate-Limiting

1989 • 155 citations

Folding of ribonuclease T1. 1. Existence of multiple unfolded states created by proline isomerization

1990 • 150 citations

The structural and sequence homology of a family of microbial ribonucleases

1983 • 141 citations

CHEMICAL NUCLEASES: NEW REAGENTS IN MOLECULAR BIOLOGY

1990 • 135 citations

DNA cleavage catalysed by the ribozyme from Tetrahymena

1990 • 130 citations

Kinetic characterization of the recombinant ribonuclease from Bacillus amyloliquefaciens (barnase) and investigation of key residues in catalysis by site-directed mutagenesis

1989 • 130 citations

Multiple mechanisms for initiation of ColE1 DNA replication: DNA synthesis in the presence and absence of ribonuclease H

1987 • 129 citations

Kinetic and magnetic resonance studies of effects of genetic substitution of a calcium-liganding amino acid in staphylococcal nuclease

1986 • 122 citations

Effect of Divalent Cations on the Reduction and Re-formation of the Disulfide Bonds of Deoxyribonuclease

1969 • 113 citations

Two histidine residues are essential for ribonuclease T1 activity as is the case for ribonuclease A

1987 • 101 citations

On the mechanism of action of ribonucleases: dinucleotide cleavage catalyzed by imidazole and Zn2+.

1989 • 99 citations

Site-directed mutants of staphylococcal nuclease. Detection and localization by proton NMR spectroscopy of conformational changes accompanying substitutions for glutamic acid-43

1987 • 92 citations

Intrinsic properties of reverse transcriptase in reverse transcription

1989 • 90 citations

RNA Editing—A Novel Genetic Phenomenon?

1990 • 85 citations

Accommodation of single amino acid insertions by the native state of staphylococcal nuclease

1990 • 80 citations

The Binding of Nucleotides and Calcium to the Extracellular Nuclease of Staphylococcus aureus

1967 • 77 citations

TRANSITION-STATE ANALOGUES IN PROTEIN CRYSTALLOGRAPHY: PROBES OF THE STRUCTURAL SOURCE OF ENZYME CATALYSIS

1990 • 77 citations

Ribonuclease H activities associated with viral reverse transcriptases are endonucleases.

1989 • 75 citations

Inhibition of RNase H activity and viral replication by single mutations in the 3' region of Moloney murine leukemia virus reverse transcriptase

1989 • 74 citations

Proton inventory of a bifunctional ribonuclease model

1989 • 73 citations

Crystallisation and preliminary crystallographic analysis of P1 nuclease from Penicillium citrinum

1990 • 72 citations

Comparison of active sites of some microbial ribonucleases: structural basis for guanylic specificity

1990 • 72 citations

A Mn ²⁺ -Dependent Ribozyme

1990 • 58 citations

Crystal structure of two covalent nucleoside derivatives of ribonuclease A

1990 • 51 citations

Energetics of RNA cleavage: implications for the mechanism of action of ribozymes

1990 • 38 citations

Syntheses and configurational analyses of thymidine 4-nitrophenyl [17O,18O]phosphates and the stereochemical course of a reaction catalyzed by bovine pancreatic deoxyribonuclease I

1984 • 27 citations

Structural and functional studies of ribonuclease T1

1989 • 24 citations

Protein-nucleic acid interaction

1990 • 24 citations

Ribonuclease T1: Struktur, Funktion und Stabilität

1991 • 22 citations

Structure of DNase I

1991 • 18 citations

A thermoresistant mutant of ribonuclease T1 having three disulfide bonds

1990 • 16 citations

Glu 46 of ribonuclease T1 is an essential residue for the recognition of guanine base

1988 • 8 citations