Structure of Ribonuclease H Phased at 2 Å Resolution by MAD Analysis of the Selenomethionyl Protein

Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features

1983 • 14,802 citations

Complete nucleotide sequence of the AIDS virus, HTLV-III

1985 • 2,236 citations

A graphics model building and refinement system for macromolecules

1978 • 1,858 citations

Cold Spring Harbor Symposia on Quantitative Biology.

1989 • 1,160 citations

Calculating the electrostatic potential of molecules in solution: Method and error assessment

1988 • 1,096 citations

Nucleotide sequence of Moloney murine leukaemia virus

1981 • 1,079 citations

Selenomethionyl proteins produced for analysis by multiwavelength anomalous diffraction (MAD): a vehicle for direct determination of three-dimensional structure.

1990 • 1,013 citations

Origins and Evolutionary Relationships of Retroviruses

1989 • 581 citations

Crystal structure of core streptavidin determined from multiwavelength anomalous diffraction of synchrotron radiation.

1989 • 579 citations

Tertiary Structure of Ribonuclease

1967 • 573 citations

Formation of an RNA primer for initiation of replication of ColE1 DNA by ribonuclease H.

1980 • 496 citations

Computer analysis of retroviral pol genes: assignment of enzymatic functions to specific sequences and homologies with nonviral enzymes.

1986 • 483 citations

Structure of myohemerythrin in the azidomet state at resolution

1987 • 377 citations

Genetic and Crystallographic Studies of the 3′,5′-Exonucleolytic Site of DNA Polymerase I

1988 • 344 citations

Cocrystal structure of an editing complex of Klenow fragment with DNA.

1988 • 324 citations

Computing in Crystallography

1980 • 301 citations

Control of cole 1 plasmid replication: The process of binding of RNA I to the primer transcript

1984 • 298 citations

A new type of X-ray area detector utilizing laser stimulated luminescence

1986 • 281 citations

Sequence‐dependent hydrolysis of RNA using modified oligonucleotide splints and RNase H

1987 • 261 citations

Isolation and Characterization of an Endonuclease from Escherichia coli Specific for Ribonucleic Acid in Ribonucleic Acid·Deoxyribonucleic Acid Hybrid Structures

1973 • 223 citations

Degradation of DNA RNA Hybrids by Ribonuclease H and DNA Polymerases of Cellular and Viral Origin

1972 • 216 citations

Retroviral reverse transcriptase: synthesis, structure, and function.

1990 • 212 citations

Molecular structure of r(GCG)d(TATACGC): a DNA–RNA hybrid helix joined to double helical DNA

1982 • 208 citations

Domain structure of the Moloney murine leukemia virus reverse transcriptase: mutational analysis and separate expression of the DNA polymerase and RNase H activities.

1988 • 206 citations

Phase Determination by Multiple-Wavelength X-Ray Diffraction: Crystal Structure of a Basic "Blue" Copper Protein from Cucumbers

1988 • 195 citations

Identification and characterization of HIV-specific RNase H by monoclonal antibody.

1988 • 191 citations

The refined crystal structure of ribonuclease A at 2.0 A resolution.

1982 • 188 citations

Metal ion requirements and other aspects of the reaction catalyzed by M1 RNA, the RNA subunit of ribonuclease P from Escherichia coli

1986 • 177 citations

Identification of the amino acid residues involved in an active site of Escherichia coli ribonuclease H by site-directed mutagenesis.

1990 • 176 citations

Design and performance of an imaging plate system for X-ray diffraction study

1988 • 170 citations

DNA sequence of the gene coding for Escherichia coli ribonuclease H.

1983 • 167 citations

A restrained-parameter structure-factor least-squares refinement procedure for large asymmetric units

1976 • 158 citations

Stereochemistry of RNA Cleavage by the Tetrahymena Ribozyme and Evidence that the Chemical Step Is Not Rate-Limiting

1989 • 155 citations

Structure of interleukin 1 .alpha. at 2.7-.ANG. resolution

1990 • 152 citations

Characteristics of self-quenching of the fluorescence of lipid-conjugated rhodamine in membranes.

1990 • 142 citations

The structural and sequence homology of a family of microbial ribonucleases

1983 • 141 citations

Multiple mechanisms for initiation of ColE1 DNA replication: DNA synthesis in the presence and absence of ribonuclease H

1987 • 129 citations

Linker insertion mutagenesis of the human immunodeficiency virus reverse transcriptase expressed in bacteria: definition of the minimal polymerase domain.

1989 • 117 citations

The structure of ribonuclease at 2.5 Ångström resolution

1974 • 116 citations

Multiple origin usage for DNA replication in sdrA(rnh) mutants of Escherichia coli K-12

1984 • 115 citations

Crystallographic structure analysis of lamprey hemoglobin from anomalous dispersion of synchrotron radiation

1988 • 93 citations

Evidence that discontinuous DNA replication in Escherichia coli is primed by approximately 10 to 12 residues of RNA starting with a purine

1985 • 91 citations

Intrinsic properties of reverse transcriptase in reverse transcription

1989 • 90 citations

Ribonuclease H (Hybrid) in Escherichia coli

1973 • 89 citations

Mutational analysis of the ribonuclease H activity of human immunodeficiency virus 1 reverse transcriptase

1990 • 81 citations

Ribonuclease H activities associated with viral reverse transcriptases are endonucleases.

1989 • 75 citations

Inhibition of RNase H activity and viral replication by single mutations in the 3' region of Moloney murine leukemia virus reverse transcriptase

1989 • 74 citations

RNase H-defective mutants of Escherichia coli: A possible discriminatory role of RNase H in initiation of DNA replication

1984 • 67 citations

Keeping the Computer Flag Flying

1971 • 64 citations

Crystal structure study of Opsanus tau parvalbumin by multiwavelength anomalous diffraction

1985 • 62 citations

Selective cloning of genes encoding RNase H from Salmonella typhimurium, Saccharomyces cerevisiae and Escherichia coli rnh mutant

1991 • 62 citations

Overproduction and preliminary crystallographic study of ribonuclease H from Escherichia coli

1989 • 61 citations

Protein Structure, Ribonuclease-S and Nucleotide Interactions

1972 • 59 citations

Specificities involved in the initiation of retroviral plus-strand DNA

1990 • 57 citations

Horizontal-type four-circle diffractometer station of the vertical wiggler beamline at the Photon Factory

1989 • 54 citations

Ribosome‐inhibiting proteins, retroviral reverse transcriptases, and RNase H share common structural elements

1988 • 49 citations

Functional organization of the murine leukemia virus reverse transcriptase: characterization of a bacterially expressed AKR DNA polymerase deficient in RNase H activity

1988 • 41 citations

dnaA suppressor (dasF) mutants of Escherichia coli are stable DNA replication (sdrA/rnh) mutants

1984 • 39 citations

Crystal structure of Clostridium acidi-urici ferredoxin at 5-A resolution based on measurements of anomalous X-ray scattering at multiple wavelengths.

1988 • 31 citations

Effect of the anisotropy of anomalous scattering on the MAD phasing method

1990 • 25 citations