Structural studies of protein–nucleic acid interaction: the sources of sequence-specific binding

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Enzyme structure and mechanism

1977 • 2,935 citations

Enzyme structure and mechanism

1978 • 2,897 citations

Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes.

1985 • 2,450 citations

PROTEIN-DNA RECOGNITION

1984 • 1,649 citations

The locus of sequence-directed and protein-induced DNA bending

1984 • 1,453 citations

Cold Spring Harbor Symposia on Quantitative Biology.

1989 • 1,160 citations

Sequence-specific recognition of double helical nucleic acids by proteins.

1976 • 1,123 citations

Resolution of phase ambiguity in macromolecular crystallography

1985 • 1,040 citations

DNA bending at adenine · thymine tracts

1986 • 1,032 citations

Structure of the nucleosome core particle at 7 Å resolution

1984 • 1,028 citations

Structure of yeast phenylalanine tRNA at 3 Å resolution

1974 • 1,000 citations

The structure of an oligo(dA)·oligo(dT) tract and its biological implications

1987 • 975 citations

Three-Dimensional Tertiary Structure of Yeast Phenylalanine Transfer RNA

1974 • 970 citations

Sequence periodicities in chicken nucleosome core DNA

1986 • 930 citations

Crystal structure of trp represser/operator complex at atomic resolution

1988 • 899 citations

Structure of a B-DNA dodecamer

1981 • 891 citations

Structure of E. coli Glutaminyl-tRNA Synthetase Complexed with tRNA ^Gln and ATP at 2.8 Å Resolution

1989 • 888 citations

Gene regulation by proteins acting nearby and at a distance

1986 • 886 citations

Evidence That the Leucine Zipper Is a Coiled Coil

1989 • 869 citations

Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP

1985 • 855 citations

Nucleic Acids and Molecular Biology

1994 • 777 citations

A control region in the center of the 5S RNA gene directs specific initiation of transcription: II. The 3′ border of the region

1980 • 734 citations

Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins

1984 • 686 citations

A bifurcated hydrogen-bonded conformation in the d(A.T) base pairs of the DNA dodecamer d(CGCAAATTTGCG) and its complex with distamycin.

1987 • 671 citations

Structure of catabolite gene activator protein at 2.9 Å resolution suggests binding to left-handed B-DNA

1981 • 651 citations

Cyclic AMP Receptor Protein: Role in Transcription Activation

1984 • 645 citations

Three-Dimensional Solution Structure of a Single Zinc Finger DNA-Binding Domain

1989 • 630 citations

Structure of the GDP Domain of EF-Tu and Location of the Amino Acids Homologous to ras Oncogene Proteins

1985 • 626 citations

2 Evolutionary and Structural Relationships among Dehydrogenases

1975 • 607 citations

Enzymatic Synthesis of Deoxyribonucleic Acid

1972 • 594 citations

Genetic Switch

2008 • 590 citations

Structure of the cro repressor from bacteriophage λ and its interaction with DNA

1981 • 545 citations

Recognition of a DNA Operator by the Repressor of Phage 434: A View at High Resolution

1988 • 531 citations

The operator-binding domain of λ repressor: structure and DNA recognition

1982 • 528 citations

Genetic Regulation: The Lac Control Region

1975 • 523 citations

Base sequence and helix structure variation in B and A DNA

1983 • 522 citations

The role of the α-helix dipole in protein function and structure

1985 • 517 citations

Integration host factor: A protein for all reasons

1988 • 501 citations

Structure of the Lambda Complex at 2.5 Å Resolution: Details of the Repressor-Operator Interactions

1988 • 500 citations

Structure of the DNA-Eco RI Endonuclease Recognition Complex at 3 Å Resolution

1986 • 492 citations

The isolation and properties of deoxyribonucleoprotein particles containing single nucleic acid molecules

1959 • 484 citations

Structure of a complex of catabolite gene activator protein and cyclic AMP refined at 2.5 Å resolution

1987 • 478 citations

The structure of the Antennapedia homeodomain determined by NMR spectroscopy in solution: Comparison with prokaryotic repressors

1989 • 468 citations

A protein structure from nuclear magnetic resonance data

1985 • 464 citations

E. coli DNA binding protein HU forms nucleosome-like structure with circular double-stranded DNA

1979 • 459 citations

Cooperative binding of λ repressors to sites separated by integral turns of the DNA helix

1986 • 450 citations

DNA structural variations in the E. coli tyrT promoter

1984 • 448 citations

Sulphate sequestered in the sulphate-binding protein of Salmonella typhimurium is bound solely by hydrogen bonds

1985 • 445 citations

Homology among DNA-binding proteins suggests use of a conserved super-secondary structure

1982 • 432 citations

DNA-Protein Interactions

1972 • 412 citations

Proposed structure for the zinc-binding domains from transcription factor IIIA and related proteins.

1988 • 411 citations

Biological Macromolecules and Assemblies

1987 • 400 citations

Structural details of the binding of guanosine diphosphate to elongation factor Tu from E. coli as studied by X-ray crystallography.

1985 • 396 citations

A hypothesis on a specific sequence-dependent conformation of DNA and its relation to the binding of the lac-repressor protein

1979 • 390 citations

Methods and programs for direct-space exploitation of geometric redundancies

1976 • 383 citations

Structure of tyrosyl-tRNA synthetase refined at 2.3 Å resolution

1989 • 375 citations

Kinky helix

1975 • 370 citations

Structure of the represser–operator complex of bacteriophage 434

1987 • 365 citations

lac repressor forms loops with linear DNA carrying two suitably spaced lac operators.

1987 • 353 citations

Sugar and Signal-Transducer Binding Sites of the Escherichia coli Galactose Chemoreceptor Protein

1988 • 344 citations

Genetic and Crystallographic Studies of the 3′,5′-Exonucleolytic Site of DNA Polymerase I

1988 • 344 citations

Nucleic Acid-Protein Recognition

1977 • 343 citations

The three-dimensional structure of trp repressor

1985 • 342 citations

Fly and frog homoeo domains show homologies with yeast mating type regulatory proteins

1984 • 341 citations

Structure of DNase I at 2.0 Å resolution suggests a mechanism for binding to and cutting DNA

1986 • 327 citations

3-Å resolution structure of a protein with histone-like properties in prokaryotes

1984 • 327 citations

Selective Elimination of the Exonuclease Activity of the Deoxyribonucleic Acid Polymerase from Escherichia coli B by Limited Proteolysis

1970 • 326 citations

Cocrystal structure of an editing complex of Klenow fragment with DNA.

1988 • 324 citations

The DNA binding domain and bending angle of E. coli CAP protein

1986 • 322 citations

Zinc-Dependent Structure of a Single-Finger Domain of Yeast ADR1

1988 • 314 citations

DNA-Binding Proteins

1983 • 308 citations

The interaction of E. coli IHF protein with its specific binding sites

1989 • 305 citations

Kinked DNA in crystalline complex with EcoRI endonuclease

1984 • 303 citations

The molecular basis of DNA–protein recognition inferred from the structure of cro repressor

1982 • 303 citations

Structure refined to 2Å of a nicked DNA octanucleotide complex with DNase I

1988 • 293 citations

Crystal structure of yeast tRNAAsp

1980 • 291 citations

Molecular cloning and nucleotide sequencing of the gene for E. coli cAMP receptor protein

1982 • 283 citations

DNA sequence determinants of CAP-induced bending and protein binding affinity

1988 • 267 citations

EXAFS study of the zinc-binding sites in the protein transcription factor IIIA

1986 • 247 citations

Mutations that alter the DNA sequence specificity of the catabolite gene activator protein of E. coli

1984 • 241 citations

tRNA IDENTITY

1989 • 240 citations

The crystal structure of trp aporepressor at 1.8 Å shows how binding tryptophan enhances DNA affinity

1987 • 240 citations

Structure of Some Crystalline Lysozyme-Inhibitor Complexes Determined by X-Ray Analysis At 6 Å Resolution

1965 • 240 citations

Structure of an alternating-B DNA helix and its relationship to A-tract DNA.

1988 • 239 citations

The lambda repressor contains two domains.

1979 • 238 citations

Three-dimensional structure of Escherichia coli initiator tRNAfMet

1980 • 238 citations

Ryanodine Receptor of Skeletal Muscle Is a Gap Junction-Type Channel

1988 • 231 citations

Crystal lattice packing is important in determining the bend of a DNA dodecamer containing an adenine tract.

1989 • 231 citations

Structure of catabolite gene activator protein at 2.9-A resolution. Incorporation of amino acid sequence and interactions with cyclic AMP.

1982 • 229 citations

How lac Repressor Binds to DNA

1972 • 228 citations

Genetic recombination

1989 • 220 citations

Sequence-dependent variation in the conformation of DNA

1981 • 220 citations

Effect of non-contacted bases on the affinity of 434 operator for 434 repressor and Cro

1987 • 217 citations

Lac Repressor

1973 • 215 citations

Helix Formation by dAT oligomers

1968 • 204 citations

Structure of a phage 434 Cro/DNA complex

1988 • 195 citations

Autoregulation of the Escherichia coli crp gene: CRP is a transcriptional repressor for its own gene

1983 • 191 citations

An active fragment of DNA polymerase produced by proteolytic cleavage

1969 • 190 citations

Lac repressor and Lac operator

1976 • 187 citations

Modification of Histones during Spermiogenesis in Trout: A Molecular Mechanism for Altering Histone Binding to DNA

1970 • 187 citations

No code for recognition

1988 • 181 citations

Cloning and sequence of the crp gene of Escherichia coli K 12

1982 • 178 citations

Three-dimensional crystal structures of Escherichia coli met repressor with and without corepressor

1989 • 177 citations

DNA-binding site of lac repressor probed by dimethylsulfate methylation of lac operator

1979 • 177 citations

Changing the binding specificity of a represser by redesigning an α-helix

1985 • 176 citations

Cold Spring Harbor symposia on quantitative biology

1987 • 174 citations

Structural similarity in the DNA-binding domains of catabolite gene activator and cro repressor proteins.

1982 • 171 citations

The DNA loop model for ara repression: AraC protein occupies the proposed loop sites in vivo and repression-negative mutations lie in these same sites.

1986 • 167 citations

A Proposed Model for Interaction of Polypeptides with RNA

1974 • 165 citations

Biological Macromolecules and Assemblies

1985 • 163 citations

A single mutational modification of a tryptophan-specific transfer RNA permits aminoacylation by glutamine and translation of the codon UAG

1974 • 162 citations

α-Helix–double helix interaction shown in the structure of a protamine-transfer RNA complex and a nucleoprotamine model

1978 • 161 citations

Hybrid protein formation of E. coli alkaline phosphatase leading to in vitro complementation

1963 • 159 citations

Crystallographic Structure of the Octameric Histone Core of the Nucleosome at a Resolution of 3.3 Å

1985 • 155 citations

The interaction of the recognition helix of lac repressor with lac operator.

1987 • 151 citations

Predicted structures of cAMP binding domains of type I and II regulatory subunits of cAMP-dependent protein kinase

1987 • 151 citations

Tyrosyl-tRNA synthetase forms a mononucleotide-binding fold

1982 • 149 citations

BIOMOLECULAR STRUCTURE, CONFORMATION, FUNCTION, AND EVOLUTION

1981 • 147 citations

Crystallographic refinement and structure of DNase I at 2 Å resolution

1986 • 145 citations

Refined structure of the gene 5 DNA binding protein from bacteriophage fd

1983 • 143 citations

Regulatory functions of the λ repressor reside in the amino-terminal domain

1979 • 143 citations

Structure of the DNA-binding region of lac repressor inferred from its homology with cro repressor.

1982 • 142 citations

A phage repressor–operator complex at 7 Å resolution

1985 • 140 citations

Mutations in lambda repressor's amino-terminal domain: implications for protein stability and DNA binding.

1983 • 139 citations

Isolation of the amino-terminal fragment of lactose repressor necessary for DNA binding

1977 • 139 citations

DNA polymerase I: from crystal structure to function via genetics

1987 • 138 citations

Crystal structure of Escherichia coli methionyl-tRNA synthetase at 2.5 Å resolution

1982 • 136 citations

Flexibility of the DNA‐binding domains of trp repressor

1988 • 133 citations

Biomolecular Structure, Conformation, Function, and Evolution

1981 • 132 citations

The crystal structure of d(GGATGGGAG) forms an essential part of the binding site for transcription factor IIIA

1986 • 132 citations

The cAMP-binding domains of the regulatory subunit of cAMP-dependent protein kinase and the catabolite gene activator protein are homologous.

1982 • 132 citations

Model of specific complex between catabolite gene activator protein and B-DNA suggested by electrostatic complementarity.

1984 • 132 citations

Substituting an α-helix switches the sequence-specific DNA interactions of a repressor

1984 • 130 citations

DNA twisting and the affinity of bacteriophage 434 operator for bacteriophage 434 repressor.

1988 • 128 citations

Complex of lac repressor headpiece with a 14 base-pair lac operator fragment studied by two-dimensional nuclear magnetic resonance

1987 • 120 citations

The N-terminal arms of λ repressor wrap around the operator DNA

1982 • 118 citations

Oligonucleotide structure: a decade of results from single crystal X-ray diffraction studies

1989 • 118 citations

Sites of allosteric shift in the structure of the cyclic AMP receptor protein

1985 • 114 citations

Secondary structural complementarity between DNA and proteins.

1977 • 111 citations

Three-dimensional structure of bovine pancreatic DNase I at 2.5 A resolution.

1984 • 110 citations

Two helix DNA binding motif of CAP found inlacrepressor andgalrepressor

1982 • 110 citations

Cooperative tandem binding of met repressor of Escherichia coli

1989 • 107 citations

Structural Studies of Protein-Nucleic Acid Interactions

1983 • 99 citations

The essential role of Ca2+ in the activity of bovine pancreatic deoxyribonuclease.

1975 • 98 citations

Structural Basis for Misaminoacylation by Mutant E. coli Glutaminyl-tRNA Synthetase Enzymes

1989 • 95 citations

Proposed α-helical super-secondary structure associated with protein-DNA recognition

1982 • 95 citations

Cleavage of the site-specific recombination protein gamma delta resolvase: the smaller of two fragments binds DNA specifically.

1984 • 94 citations

Protein structure, folding and design

1985 • 93 citations

Comparison of the structures of Cro and λ repressor proteins from bacteriophage λ

1983 • 91 citations

In vitro conversion of a methionine to a glutamine-acceptor tRNA

1985 • 91 citations

A domain of the klenow fragment of Escherichia coli DNA polymerase I has polymerase but no exonuclease activity

1986 • 90 citations

Role of glutamic acid-181 in DNA-sequence recognition by the catabolite gene activator protein (CAP) of Escherichia coli: altered DNA-sequence-recognition properties of [Val181]CAP and [Leu181]CAP.

1987 • 89 citations

Is DNA unwound by the cyclic AMP receptor protein?

1982 • 87 citations

Synthetic lac operator mediates repression through lac repressor when introduced upstream and downstream from lac promoter.

1986 • 87 citations

Mischarging in mutant tyrosine transfer RNAs

1972 • 85 citations

Homologous interactions of λ repressor and λ Cro with the λ operator

1986 • 85 citations

Mutations that alter the allosteric nature of cAMP receptor protein of Escherichia coli.

1985 • 85 citations

Mutant tyrosine tRNA of altered amino acid specificity

1972 • 82 citations

Cocrystals of the DNA-binding domain of phage 434 repressor and a synthetic phage 434 operator.

1984 • 80 citations

Interaction of the cAMP receptor protein with the lac promoter.

1980 • 78 citations

Suppression of Amber Codons in Vivo as Evidence That Mutants Derived from Escherichia coli Initiator tRNA Can Act at the Step of Elongation in Protein Synthesis

1989 • 78 citations

Electrostatic calculations and model‐building suggest that DNA bound to CAP is sharply bent

1987 • 77 citations

Conformations of 145 base pair length poly (dG-dC)·poly (dG-dC) in solution and in association with histones

1980 • 77 citations

DNA site recognition and reduced specificity of the Eco RI endonuclease.

1980 • 76 citations

Analogs of cyclic AMP that elicit the biochemically defined conformational change in catabolite gene activator protein (CAP) but do not stimulate binding to DNA

1985 • 70 citations

The lac Repressor Protein: Molecular Shape, Subunit Structure, and Proposed Model for Operator Interaction Based on Structural Studies of Microcrystals

1974 • 69 citations

Mechanism of selective inhibition of 3' to 5' exonuclease activity of Escherichia coli DNA polymerase I by nucleoside 5'-monophosphates

1978 • 68 citations

λ Repressor: A Model System for Understanding Protein–DNA Interactions and Protein Stability

1990 • 65 citations

Proton nuclear magnetic resonance studies on cyclic nucleotide binding to the Escherichia coli adenosine cyclic 3',5'-phosphate receptor protein

1982 • 65 citations

Sequence homology between Lac and Gal repressors and three sugar-binding periplasmic proteins

1983 • 65 citations

Systematic Variation in DNA Length Yields Highly Ordered Repressor-Operator Cocrystals

1985 • 63 citations

Limited proteolytic digestion of lac repressor by trypsin. Chemical nature of the resulting trypsin-resistant core.

1976 • 61 citations

Recent Excitement in Understanding Transfer RNA Identity

1988 • 61 citations

Fingering too many proteins

1988 • 61 citations

Mutants of the catabolite activator protein of Escherichia coli that are specifically deficient in the gene-activation function.

1987 • 58 citations

tRNA identity: A hair of the dogma that bit us

1988 • 55 citations

The change of DNA structure by specific binding of the cAMP receptor protein from rotation diffusion and dichroism measurements.

1984 • 53 citations

Protein Structure, Folding and Design

1988 • 53 citations

Structure-activity relationships of methionyl-tRNA synthetase: graphics modelling and genetic engineering

1987 • 52 citations

Crystallization of Escherichia coli catabolite gene activator protein with its DNA binding site

1990 • 47 citations

Interaction of mutant λ repressors with operator and non-operator DNA

1986 • 44 citations

Transposition of Tn3 and related transposons

1983 • 44 citations

Investigations on stimulation of lac transcription in vivo in Escherichia coli by cAMP analogues

1984 • 43 citations

Preparation of heavy-atom derivatives using site-directed mutagenesis

1989 • 43 citations

Escherichia coli lac repressor is elongated with its operator DNA binding domains located at both ends

1982 • 39 citations

‘Interactive’ recognition inEcoRl restriction enzyme-DNA complex

1984 • 38 citations

Protein-DNA interaction investigated by binding Escherichia coli lac repressor protein to poly[d(A · U-HgX)]

1976 • 38 citations

Neutron scattering studies of lac repressor

1980 • 36 citations

DNA sequence determinants of lambda repressor binding in vivo.

1988 • 34 citations

High Resolution Structural Studies of Cro Repressor Protein and Implications for DNA Recognition

1983 • 33 citations

Crystallization of a complex of cro repressor with a 17 base-pair operator

1986 • 32 citations

Probing the sequence-specific interaction of the cyclic AMP receptor protein with DNA by site-directed mutagenesis

1987 • 30 citations

Visualization of cAMP receptor protein-induced DNA kinking by electron microscopy

1984 • 27 citations

Preliminary X-ray diffraction studies of EcoRI restriction endonuclease-DNA complex

1981 • 24 citations

A model for the non-specific binding of catabolite gene activator protein to DNA

1984 • 23 citations

Crystallographic data for complexes of the Cro repressor with DNA

1983 • 21 citations

Aminoacylation of the Ambivalent Su+7 Amber Suppressor tRNA

1977 • 16 citations

Crystallographic Studies of Protein-Nucleic Acid Interaction: Catabolite Gene Activator Protein and the Large Fragment of DNA Polymerase I

1983 • 13 citations

RNA Structure

1989 • 11 citations

Preliminary X-ray diffraction studies of the putative catalytic domain of gamma delta resolvase from Escherichia coli.

1986 • 5 citations