Natural Killer Cells

Interleukin-12 and the regulation of innate resistance and adaptive immunity

2003 • 3,689 citations

Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants

2002 • 3,274 citations

The biology of human natural killer-cell subsets

2001 • 2,801 citations

In search of the ‘missing self’: MHC molecules and NK cell recognition

1990 • 2,600 citations

NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines

1999 • 2,128 citations

HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

1998 • 2,114 citations

Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy

1986 • 2,102 citations

„Natural”︁ killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype

1975 • 1,743 citations

Activating Receptors and Coreceptors Involved in Human Natural Killer Cell-Mediated Cytolysis

2001 • 1,728 citations

IgG Fc Receptors

2001 • 1,667 citations

NK CELL RECEPTORS

1998 • 1,666 citations

Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivity and specificity

1975 • 1,308 citations

Roles of the NKG2D immunoreceptor and its ligands

2003 • 1,297 citations

Severe Herpesvirus Infections in an Adolescent without Natural Killer Cells

1989 • 1,251 citations

Natural killer cells and pregnancy

2002 • 1,216 citations

Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors

2002 • 1,195 citations

Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS

2002 • 1,170 citations

„Natural”︁ killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characteristics of the killer cell

1975 • 1,090 citations

Fundamental Immunology

1999 • 1,011 citations

KIR: Diverse, Rapidly Evolving Receptors of Innate and Adaptive Immunity

2002 • 983 citations

Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells

2001 • 961 citations

Interleukin 15: biology and relevance to human disease

2001 • 947 citations

The Selective Downregulation of Class I Major Histocompatibility Complex Proteins by HIV-1 Protects HIV-Infected Cells from NK Cells

1999 • 870 citations

Natural killer cells, viruses and cancer

2001 • 859 citations

Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. II. Characterization of effector cells

1975 • 844 citations

Development of peripheral lymphoid organs and natural killer cells depends on the helix–loop–helix inhibitor Id2

1999 • 841 citations

MHC class I alloantigen specificity of Ly-49+ IL-2-activated natural killer cells

1992 • 805 citations

Recognition of a virus-encoded ligand by a natural killer cell activation receptor

2002 • 754 citations

The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal

2003 • 751 citations

Functionally and Structurally Distinct NK Cell Receptor Repertoires in the Peripheral Blood of Two Human Donors

1997 • 735 citations

New aspects of natural-killer-cell surveillance and therapy of cancer

2002 • 713 citations

Natural killer cells and dendritic cells: rendezvous in abused tissues

2002 • 674 citations

Surface Expression of HLA-E, an Inhibitor of Natural Killer Cells, Enhanced by Human Cytomegalovirus gpUL40

2000 • 641 citations

Cutting Edge: Down-Regulation of MICA on Human Tumors by Proteolytic Shedding

2002 • 624 citations

Response of resting human peripheral blood natural killer cells to interleukin 2.

1984 • 616 citations

Immune functions encoded by the natural killer gene complex

2003 • 564 citations

The Abundant NK Cells in Human Secondary Lymphoid Tissues Require Activation to Express Killer Cell Ig-Like Receptors and Become Cytolytic

2004 • 561 citations

Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors

2003 • 549 citations

P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities.

1993 • 537 citations

Regulation of the Natural Killer Cell Receptor Repertoire

2001 • 531 citations

Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect

2002 • 500 citations

Role of interleukin-15 in the development of human CD56+ natural killer cells from CD34+ hematopoietic progenitor cells

1996 • 495 citations

What does it take to make a natural killer?

2003 • 481 citations

Evidence for a similar or common mechanism for natural killer cell activity and resistance to hemopoietic grafts

1977 • 467 citations

Isolation of human NK cells by density gradient centrifugation

1980 • 462 citations

The killer cell immunoglobulin‐like receptor (KIR) genomic region: gene‐order, haplotypes and allelic polymorphism

2002 • 438 citations

Natural Killer Cells and Cancer

2003 • 432 citations

Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice

1991 • 419 citations

The human natural killer cell immune synapse

1999 • 418 citations

In vivonatural killer cell activities revealed by natural killer cell-deficient mice

2000 • 406 citations

Natural killer cell receptor signaling

2003 • 380 citations

Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants

2002 • 375 citations

Natural killer cells in HIV-1 infection: Dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates

2003 • 374 citations

Fas-mediated cytotoxicity by freshly isolated natural killer cells.

1995 • 372 citations

The Inhibitory Receptor LIR-1 Uses a Common Binding Interaction to Recognize Class I MHC Molecules and the Viral Homolog UL18

1999 • 357 citations

PECULIAR IMMUNOBIOLOGY OF BONE MARROW ALLOGRAFTS

1971 • 349 citations

Leishmania lipophosphoglycan (LPG) activates NK cells through toll-like receptor-2

2003 • 345 citations

Structure and Function of Natural Killer Cell Receptors: Multiple Molecular Solutions to Self, Nonself Discrimination

2002 • 336 citations

Cutting Edge: Susceptibility to Psoriatic Arthritis: Influence of Activating Killer Ig-Like Receptor Genes in the Absence of Specific HLA-C Alleles

2002 • 333 citations

The role of natural killer cells in innate resistance to infection

1993 • 330 citations

Expression and Function of TNF-Related Apoptosis-Inducing Ligand on Murine Activated NK Cells

1999 • 330 citations

Role of NKG2D in tumor cell lysis mediated by human NK cells: cooperation with natural cytotoxicity receptors and capability of recognizing tumors of nonepithelial origin

2001 • 329 citations

The class I MHC homologue of human cytomegalovirus inhibits attack by natural killer cells

1997 • 327 citations

The genomic context of natural killer receptor extended gene families

2001 • 310 citations

Innate Immune Response to Malaria: Rapid Induction of IFN-γ from Human NK Cells by LivePlasmodium falciparum-Infected Erythrocytes

2002 • 306 citations

NK Cells, MHC Class I Molecules and the Missing Self

2002 • 305 citations

The impaired NK cell cytolytic function in viremic HIV‐1 infection is associated with a reduced surface expression of natural cytotoxicity receptors (NKp46, NKp30 and NKp44)

2003 • 294 citations

Human Cytomegalovirus Glycoprotein UL16 Causes Intracellular Sequestration of NKG2D Ligands, Protecting Against Natural Killer Cell Cytotoxicity

2003 • 282 citations

NKG2D-mediated Natural Killer Cell Protection Against Cytomegalovirus Is Impaired by Viral gp40 Modulation of Retinoic Acid Early Inducible 1 Gene Molecules

2003 • 278 citations

Dendritic and Natural Killer Cells Cooperate in the Control/Switch of Innate Immunity

2002 • 277 citations

Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors

2003 • 272 citations

The CD94 and NKG2‐A C‐type lectins covalently assemble to form a natural killer cell inhibitory receptor for HLA class I molecules

1997 • 271 citations

Regulation of Trypanosoma cruzi infection in mice by gamma interferon and interleukin 10: role of NK cells

1996 • 270 citations

Natural killer (NK) cell-derived hematopoietic colony-inhibiting activity and NK cytotoxic factor. Relationship with tumor necrosis factor and synergism with immune interferon.

1985 • 249 citations

In Vivo Survival and Homeostatic Proliferation of Natural Killer Cells

2003 • 238 citations

Recognition of the Class Ib Molecule Qa-1b by Putative Activating Receptors Cd94/Nkg2c and Cd94/Nkg2e on Mouse Natural Killer Cells

1999 • 233 citations

Genetic variation of in vitro cytolytic activity and in vivo rejection potential of non‐immunized semi‐syngeneic mice against a mouse lymphoma line

1975 • 230 citations

Clinical features of large granular lymphocyte leukemia

2003 • 229 citations

KIR in Type 1 Diabetes

2003 • 225 citations

Human Natural Killer Cells: Origin, Clonality, Specificity, and Receptors

1993 • 222 citations

Prevention of Allogeneic Bone Marrow Graft Rejection by H-2 Transgene in Donor Mice

1989 • 218 citations

Murine Natural Killer Cells and Marrow Graft Rejection

1992 • 217 citations

Killer Cell Activating Receptors Function as Costimulatory Molecules on CD4+CD28null T Cells Clonally Expanded in Rheumatoid Arthritis

2000 • 217 citations

MCMV glycoprotein gp40 confers virus resistance to CD8+ T cells and NK cells in vivo

2002 • 216 citations

Uterine natural killer cells: insights into their cellular and molecular biology from mouse modelling

2003 • 216 citations

Viral evasion of natural killer cells

2002 • 213 citations

The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function

2000 • 210 citations

The role of natural killer cells in host—parasite interactions

1995 • 209 citations

Natural killer cell activation in mice and men: different triggers for similar weapons?

2002 • 204 citations

Cis association of Ly49A with MHC class I restricts natural killer cell inhibition

2004 • 200 citations

Emergence of NK1.1+ cells as effectors of IFN-gamma dependent immunity to Toxoplasma gondii in MHC class I-deficient mice.

1993 • 193 citations

Role of natural killer cells in control of cancer metastasis

1982 • 190 citations

Natural killer cells determine the outcome of B cell–mediated autoimmunity

2000 • 187 citations

A Central Role for Death Receptor-Mediated Apoptosis in the Rejection of Tumors by NK Cells

2001 • 185 citations

Effects of Human Cytomegalovirus Infection on Ligands for the Activating NKG2D Receptor of NK Cells: Up-Regulation of UL16-Binding Protein (ULBP)1 and ULBP2 Is Counteracted by the Viral UL16 Protein

2003 • 182 citations

Expression and function of NK cell receptors in CD8+ T cells

2001 • 177 citations

A structural perspective on MHC class I recognition by killer cell immunoglobulin-like receptors

2002 • 173 citations

The NKp46 Receptor Contributes to NK Cell Lysis of Mononuclear Phagocytes Infected with an Intracellular Bacterium

2002 • 162 citations

Alloreactive killer cells: hindrance and help for haematopoietic transplants

2003 • 155 citations

Natural killer cells wear different hats: effector cells of innate resistance and regulatory cells of adaptive immunity and of hematopoiesis

1995 • 154 citations

Toll-like Receptor 9, CpG DNA and Innate Immunity

2002 • 152 citations

Natural Killer Cell Tolerance in Mice with Mosaic Expression of Major Histocompatibility Complex Class I Transgene

1997 • 146 citations

Natural Killer Cells and Tumor Therapy

1998 • 143 citations

Diversity of NK Cell Receptor Repertoire in Adult and Neonatal Mice

1999 • 143 citations

Generation of Lytic Natural Killer 1.1+, Ly-49− Cells from Multipotential Murine Bone Marrow Progenitors in a Stroma-free Culture: Definition of Cytokine Requirements and Developmental Intermediates

1997 • 139 citations

Assembly of the immunological synapse for T cells and NK cells

2002 • 138 citations

Mouse Ly-49D Recognizes H-2Dd and Activates Natural Killer Cell Cytotoxicity

1999 • 137 citations

Association of a syndrome resembling Wegener's granulomatosis with low surface expression of HLA class-I molecules

1999 • 135 citations

Activity and Phenotype of Natural Killer Cells in Peptide Transporter (TAP)-deficient Patients (Type I Bare Lymphocyte Syndrome)

1998 • 134 citations

Altered phenotype and function of natural killer cells expressing the major histocompatibility complex receptor Ly-49 in mice transgenic for its ligand.

1995 • 134 citations

Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2Kb

2003 • 133 citations

The ever‐expanding Ly49 gene family: repertoire and signaling

2001 • 132 citations

A family of inhibitory and activating Ig-like receptors that modulate function of lymphoid and myeloid cells

2000 • 129 citations

Clonal Acquisition of Inhibitory Ly49 Receptors on Developing NK Cells Is Successively Restricted and Regulated by Stromal Class I MHC

2000 • 128 citations

LIRs/ILTs/MIRs, inhibitory and stimulatory Ig-superfamily receptors expressed in myeloid and lymphoid cells

2000 • 125 citations

How to recongnize a foreign submarine

1997 • 124 citations

Signaling pathways engaged by NK cell receptors: double concerto for activating receptors, inhibitory receptors and NK cells

2000 • 122 citations

Natural killer cells and autoimmunity.

2003 • 119 citations

The Role of NK Cells in Autoimmune Disease

2002 • 118 citations

Control of Infections by NK Cells

1998 • 118 citations

Cell-mediated killing: A common mechanism?

1986 • 114 citations

Pivotal Role of KARAP/DAP12 Adaptor Molecule in the Natural Killer Cell–mediated Resistance to Murine Cytomegalovirus Infection

2002 • 113 citations

Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: Engagement of CD33 induces apoptosis of leukemic cells

2001 • 109 citations

Regulation of perforin‐independent NK cell‐mediated cytotoxicity

2003 • 93 citations

The natural killer gene complex genetic locusChokencodes Ly-49D, a target recognition receptor that activates natural killing

1999 • 92 citations

Inhibitory Receptors Alter Natural Killer Cell Interactions with Target Cells Yet Allow Simultaneous Killing of Susceptible Targets

1999 • 91 citations

Granulysin

2000 • 91 citations

The Natural Killer Cell – Friend or Foe in Autoimmune Disease?

2002 • 89 citations

Clonal Acquisition of the Ly49A NK Cell Receptor Is Dependent on the trans-Acting Factor TCF-1

1999 • 84 citations

Cutting Edge: The NK Cell Receptor 2B4 Augments Antigen-Specific T Cell Cytotoxicity Through CD48 Ligation on Neighboring T Cells

2003 • 82 citations

ROLE OF TARGET HISTOCOMPATIBILITY ANTIGENS IN REGULATION OF NATURAL KILLER ACTIVITY: A REEVALUATION AND A HYPOTHESIS11Based on a doctoral thesis at The Karolinska Institute, supported by grants from the Karolinska Institute, The Swedish Cancer Society, The National Cancer Institute (US DHEW) and The Engwall Foundation.

1985 • 76 citations

Innate Immune Responses to LCMV Infections: Natural Killer Cells and Cytokines

2002 • 74 citations

A comparison of efficacy and specificity of three NK depleting antibodies

1996 • 66 citations

KIR expression shapes cytotoxic repertoires: a developmental program of survival

2002 • 66 citations

Expression of HLA class I-specific inhibitory receptors in human cytolytic T lymphocytes: a regulated mechanism that controls T-cell activation and function

2000 • 59 citations

NK Cells and HIV Infection: Lessons from other Viruses

2002 • 56 citations

The immunobiology of natural killer cells and bone marrow allograft rejection

2003 • 56 citations

Specificity and function of activating Ly‐49 receptors

2001 • 53 citations

Natural killer cells and reproduction

2002 • 51 citations

Immunotherapy of patients with advanced cancer using interleukin-2 alone or in combination with lymphokine activated killer cells.

1988 • 48 citations

Cytotoxic Lymphocyte Recognition of HLA-E

1998 • 46 citations

External and Internal Calibration of the MHC Class I-Specific Receptor Ly49A on Murine Natural Killer Cells

1998 • 46 citations

Hybrid resistance: ‘negative’ and ‘positive’ signaling of murine natural killer cells

1995 • 42 citations

Natural killer cell activation receptors in innate immunity to infection

2002 • 37 citations

Natural Killer Cell Subsets and Development

1996 • 36 citations

Viral Evasion of Natural Killer Cells During Human Cytomegalovirus Infection

2002 • 33 citations

Enterobacterial infection modulates major histocompatibility complex class I expression on mononuclear cells

1999 • 32 citations

The NK cell receptor repertoire: formation, adaptation and exploitation

2003 • 31 citations

Innate immunity to cytomegalovirus: the Cmv1 locus and its role in natural killer cell function

2002 • 26 citations

The cytolytic activity of natural killer cells is not involved in the restriction of Mycobacterium avium growth

2003 • 23 citations

Molecular genetic characterization of the distal NKC recombination hotspot and putative murine CMV resistance control locus

2003 • 17 citations

Models for Natural Killer Cell Repertoire Formation

2003 • 11 citations

MHC class I receptors on natural killer cells: on with the old and in with the new

2003 • 6 citations