NK Cells, MHC Class I Molecules and the Missing Self

In search of the ‘missing self’: MHC molecules and NK cell recognition

1990 • 2,600 citations

Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy

1986 • 2,102 citations

„Natural”︁ killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype

1975 • 1,743 citations

Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivity and specificity

1975 • 1,308 citations

Association of class I major histocompatibility heavy and light chains induced by viral peptides

1989 • 995 citations

MHC class I alloantigen specificity of Ly-49+ IL-2-activated natural killer cells

1992 • 805 citations

Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Enhancement of human natural killer cell activity by interferon and antagonistic inhibition of susceptibility of target cells to lysis.

1978 • 744 citations

Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism.

1985 • 734 citations

Vital Involvement of a Natural Killer Cell Activation Receptor in Resistance to Viral Infection

2001 • 622 citations

P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities.

1993 • 537 citations

Evidence for a similar or common mechanism for natural killer cell activity and resistance to hemopoietic grafts

1977 • 467 citations

Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice

1991 • 419 citations

PECULIAR IMMUNOBIOLOGY OF BONE MARROW ALLOGRAFTS

1971 • 349 citations

Restoration of antigen presentation to the mutant cell line RMA-S by an MHC-linked transporter

1991 • 329 citations

Recognition of beta 2-microglobulin-negative (beta 2m-) T-cell blasts by natural killer cells from normal but not from beta 2m- mice: nonresponsiveness controlled by beta 2m- bone marrow in chimeric mice.

1991 • 269 citations

Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes.

1989 • 241 citations

Genetic variation of in vitro cytolytic activity and in vivo rejection potential of non‐immunized semi‐syngeneic mice against a mouse lymphoma line

1975 • 230 citations

Prevention of Allogeneic Bone Marrow Graft Rejection by H-2 Transgene in Donor Mice

1989 • 218 citations

YAC-1 MHC class I variants reveal an association between decreased NK sensitivity and increased H-2 expression after interferon treatment or in vivo passage.

1985 • 171 citations

Natural killer cells mediate lysis of embryonal carcinoma cells lacking MHC

1980 • 142 citations

How to recongnize a foreign submarine

1997 • 124 citations

Natural resistance against lymphoma grafts conveyed by H-2Dd transgene to C57BL mice.

1988 • 116 citations

Molecular analysis of H-2-deficient lymphoma lines. Distinct defects in biosynthesis and association of MHC class I heavy chains and beta 2-microglobulin observed in cells with increased sensitivity to NK cell lysis.

1989 • 115 citations

Interferon gamma induces lung colonization by intravenously inoculated B16 melanoma cells in parallel with enhanced expression of class I major histocompatibility complex antigens.

1987 • 107 citations

Increased resistance to non-MHC-restricted cytotoxicity related to HLA A, B expression. Direct demonstration using beta 2-microglobulin-transfected Daudi cells.

1988 • 106 citations

Inhibitory Receptors Alter Natural Killer Cell Interactions with Target Cells Yet Allow Simultaneous Killing of Susceptible Targets

1999 • 91 citations

The Rapid Elimination of Allogeneic Lymphocytes: Relationship to Established Mechanisms of Immunity and to Lymphocyte Traffic

1983 • 79 citations

ROLE OF TARGET HISTOCOMPATIBILITY ANTIGENS IN REGULATION OF NATURAL KILLER ACTIVITY: A REEVALUATION AND A HYPOTHESIS11Based on a doctoral thesis at The Karolinska Institute, supported by grants from the Karolinska Institute, The Swedish Cancer Society, The National Cancer Institute (US DHEW) and The Engwall Foundation.

1985 • 76 citations

Tumorigenicity conferred to lymphoma mutant by major histocompatibility complex-encoded transporter gene.

1993 • 65 citations

Resistance to H-2-restricted but not to allo-H2-specific graft and cytotoxic T lymphocyte responses in lymphoma mutant.

1990 • 63 citations

Transfection of beta 2-microglobulin restores IFN-mediated protection from natural killer cell lysis in YAC-1 lymphoma variants.

1990 • 60 citations

Colony Specificity in the Colonial Tunicate Botryllus and the Origins of Vertebrate Immunity

1982 • 57 citations

Resistance to H-2-restricted but not to allo-H2-specific graft and cytotoxic T lymphocyte responses in lymphoma mutant.

1990 • 46 citations

Afferent and efferent cellular interactions in natural resistance directed against MHC class I deficient tumor grafts.

1988 • 43 citations

MHC gene control of the natural killer system at the level of the target and the host.

1991 • 36 citations

Selective acceptance of MHC class I-deficient tumor grafts in the brain.

1988 • 35 citations

Recognition structures determined by the H-2 complex.

1976 • 34 citations

Natural killer cells and the MHC class I pathway of peptide presentation

1993 • 34 citations

Specific immunorecognition by histocompatibility markers: The original polymorphic system of immunoreactivity characteristic of all multicellular animals

1977 • 26 citations

Multiple interactions at the natural killer workshop

1991 • 25 citations

On the phylogenetic origin of the immune system a hypothesis

1977 • 21 citations