Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect

Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants

2002 • 3,274 citations

Biology of Natural Killer Cells

1989 • 2,970 citations

The biology of human natural killer-cell subsets

2001 • 2,801 citations

Graft-versus-leukemia reactions after bone marrow transplantation

1990 • 2,781 citations

In search of the ‘missing self’: MHC molecules and NK cell recognition

1990 • 2,600 citations

HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

1998 • 2,114 citations

Activating Receptors and Coreceptors Involved in Human Natural Killer Cell-Mediated Cytolysis

2001 • 1,728 citations

NK CELL RECEPTORS

1998 • 1,666 citations

Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset

2001 • 1,364 citations

Progress in human tumour immunology and immunotherapy

2001 • 1,327 citations

Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation.

1997 • 1,290 citations

ULBPs, Novel MHC Class I–Related Molecules, Bind to CMV Glycoprotein UL16 and Stimulate NK Cytotoxicity through the NKG2D Receptor

2001 • 1,190 citations

Human Diversity in Killer Cell Inhibitory Receptor Genes

1997 • 1,052 citations

Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium.

1996 • 1,010 citations

Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB

1999 • 1,006 citations

HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A

1998 • 998 citations

Role of Natural Killer Cell Alloreactivity in HLA-Mismatched Hematopoietic Stem Cell Transplantation

1999 • 993 citations

Interleukin 15: biology and relevance to human disease

2001 • 947 citations

Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells

2001 • 937 citations

A Common Inhibitory Receptor for Major Histocompatibility Complex Class I Molecules on Human Lymphoid and Myelomonocytic Cells

1997 • 933 citations

Biology and clinical relevance of human natural killer cells

1990 • 930 citations

Bone Marrow Transplantation for Chronic Myelogenous Leukemia in Chronic Phase

1988 • 887 citations

The Selective Downregulation of Class I Major Histocompatibility Complex Proteins by HIV-1 Protects HIV-Infected Cells from NK Cells

1999 • 870 citations

Interferon γ Contributes to Initiation of Uterine Vascular Modification, Decidual Integrity, and Uterine Natural Killer Cell Maturation during Normal Murine Pregnancy

2000 • 805 citations

A second lineage of mammalian major histocompatibility complex class I genes.

1994 • 779 citations

Identification and Molecular Characterization of Nkp30, a Novel Triggering Receptor Involved in Natural Cytotoxicity Mediated by Human Natural Killer Cells

1999 • 758 citations

Functionally and Structurally Distinct NK Cell Receptor Repertoires in the Peripheral Blood of Two Human Donors

1997 • 735 citations

Cloning of Immunoglobulin-Superfamily Members Associated with HLA-C and HLA-B Recognition by Human Natural Killer Cells

1995 • 735 citations

NKp44, a Novel Triggering Surface Molecule Specifically Expressed by Activated Natural Killer Cells, Is Involved in Non–Major Histocompatibility Complex–restricted Tumor Cell Lysis

1998 • 719 citations

A Human Histocompatibility Leukocyte Antigen (HLA)-G–specific Receptor Expressed on All Natural Killer Cells

1999 • 711 citations

Recognition of Human Histocompatibility Leukocyte Antigen (HLA)-E Complexed with HLA Class I Signal Sequence–derived Peptides by CD94/NKG2 Confers Protection from Natural Killer Cell–mediated Lysis

1998 • 706 citations

Comparative studies of human FcRIII-positive and negative natural killer cells.

1989 • 688 citations

A Novel Immunoglobulin Superfamily Receptor for Cellular and Viral MHC Class I Molecules

1997 • 681 citations

Hematopoietic Cell Transplantation

2015 • 664 citations

Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumorin vivo

2001 • 588 citations

Molecular Cloning of NKp46: A Novel Member of the Immunoglobulin Superfamily Involved in Triggering of Natural Cytotoxicity

1998 • 562 citations

P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities.

1993 • 537 citations

Regulation of the Natural Killer Cell Receptor Repertoire

2001 • 531 citations

p46, a Novel Natural Killer Cell–specific Surface Molecule That Mediates Cell Activation

1997 • 518 citations

Hematopoietic Cell Transplantation

2000 • 514 citations

HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells.

1993 • 455 citations

Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits.

1996 • 441 citations

NKp44, A Triggering Receptor Involved in Tumor Cell Lysis by Activated Human Natural Killer Cells, Is a Novel Member of the Immunoglobulin Superfamily

1999 • 437 citations

Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors.

1990 • 436 citations

DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells.

1991 • 430 citations

Complex structure of the activating immunoreceptor NKG2D and its MHC class I–like ligand MICA

2001 • 389 citations

Identification of four subsets of human CD3-CD16+ natural killer (NK) cells by the expression of clonally distributed functional surface molecules: correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition.

1990 • 388 citations

Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF.

1992 • 369 citations

HLA-E-bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: preferential response to an HLA-G-derived nonamer

1998 • 366 citations

The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer.

1996 • 365 citations

Kinetics and peptide dependency of the binding of the inhibitory NK receptor CD94/NKG2-A and the activating receptor CD94/NKG2-C to HLA-E

1999 • 355 citations

The ILT2(LIR1) and CD94/NKG2A NK cell receptors respectively recognize HLA-G1 and HLA-E molecules co-expressed on target cells

1999 • 355 citations

A human killer inhibitory receptor specific for HLA-A1,2.

1996 • 347 citations

NKB1: a natural killer cell receptor involved in the recognition of polymorphic HLA-B molecules.

1994 • 343 citations

Protection from lysis by natural killer cells of group 1 and 2 specificity is mediated by residue 80 in human histocompatibility leukocyte antigen C alleles and also occurs with empty major histocompatibility complex molecules.

1996 • 340 citations

Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer

1995 • 338 citations

The human leukocyte antigen (HLA)-C-specific "activatory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions.

1996 • 337 citations

Role of NKG2D in tumor cell lysis mediated by human NK cells: cooperation with natural cytotoxicity receptors and capability of recognizing tumors of nonepithelial origin

2001 • 329 citations

Suppression of graft-versus-host disease and amplification of graft-versus-tumor effects by activated natural killer cells after allogeneic bone marrow transplantation.

1998 • 305 citations

Activation of cytolytic T lymphocyte and natural killer cell function through the T11 sheep erythrocyte binding protein

1985 • 287 citations

Functional and biochemical analysis of CD16 antigen on natural killer cells and granulocytes.

1988 • 280 citations

Phase iii randomized trial of interleukin-2 with or without lymphokine-activated killer cells in the treatment of patients with advanced renal cell carcinoma

1995 • 278 citations

The CD94 and NKG2‐A C‐type lectins covalently assemble to form a natural killer cell inhibitory receptor for HLA class I molecules

1997 • 271 citations

Selective modulation of human natural killer cells in vivo after prolonged infusion of low dose recombinant interleukin 2.

1993 • 259 citations

Cutting Edge: Induction of IFN-γ Production but Not Cytotoxicity by the Killer Cell Ig-Like Receptor KIR2DL4 (CD158d) in Resting NK Cells

2001 • 255 citations

NKG2A Complexed with CD94 Defines a Novel Inhibitory Natural Killer Cell Receptor

1997 • 252 citations

A New Mechanism of NK Cell Cytotoxicity Activation: The CD40–CD40 Ligand Interaction

1997 • 244 citations

Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes.

1989 • 241 citations

Human natural killer cells with polyclonal lectin and immunoglobulinlike receptors develop from single hematopoietic stem cells with preferential expression of NKG2A and KIR2DL2/L3/S2

2001 • 230 citations

Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes.

1993 • 226 citations

2B4 functions as a co-receptor in human NK cell activation

2000 • 222 citations

Flt3 Ligand Promotes the Generation of a Distinct CD34+Human Natural Killer Cell Progenitor That Responds to Interleukin-15

1998 • 222 citations

MIC Genes: From Genetics to Biology

2001 • 221 citations

CD69 is a stimulatory receptor for natural killer cell and its cytotoxic effect is blocked by CD94 inhibitory receptor

1999 • 217 citations

Murine Natural Killer Cells and Marrow Graft Rejection

1992 • 217 citations

Induction of NK cell activity against fresh human leukemia in culture with interleukin 2.

1987 • 215 citations

Molecular characterization of human CD94: A type II membrane glycoprotein related to the C‐type lectin superfamily

1995 • 207 citations

Identification of NKp80, a novel triggering molecule expressed by human NK cells

2001 • 200 citations

Cytotoxicity of interleukin 2-activated lymphocytes for leukemia and lymphoma cells

1986 • 179 citations

Molecular dynamics of MHC genesis unraveled by sequence analysis of the 1,796,938-bp HLA class I region

1999 • 179 citations

Crystal Structure of the MHC Class I Homolog MIC-A, a γδ T Cell Ligand

1999 • 178 citations

Natural killer cell activation and inhibition by receptors for MHC class I

1999 • 166 citations

Loss of HLA haplotype and B locus down-regulation in melanoma cell lines.

1994 • 163 citations

p49, a putative HLA class I-specific inhibitory NK receptor belonging to the immunoglobulin superfamily

1998 • 155 citations

Augmentation of antitumor effects by NK cell inhibitory receptor blockade in vitro and in vivo

2001 • 153 citations

Effect of low-dose interleukin-2 on disease relapse after T-cell- depleted allogeneic bone marrow transplantation

1994 • 152 citations

The UL16‐binding proteins, a novel family of MHC class I‐related ligands for NKG2D, activate natural killer cell functions

2001 • 144 citations

CD11a-c/CD18 and GP84 (LB-2) adhesion molecules on human large granular lymphocytes and their participation in natural killing.

1988 • 143 citations

Skin graft rejection by beta 2-microglobulin-deficient mice.

1992 • 142 citations

Prospects for adoptive T cell therapy

1997 • 139 citations

A novel functional cell surface dimer (Kp43) expressed by natural killer cells and T cell receptor-gamma/delta+ T lymphocytes. I. Inhibition of the IL-2-dependent proliferation by anti-Kp43 monoclonal antibody.

1990 • 136 citations

Demonstration by class I gene transfer that reduced susceptibility of human cells to natural killer cell‐mediated lysis is inversely correlated with HLA class I antigen expression

1989 • 133 citations

Differential responses to interleukin 2 define functionally distinct subsets of human natural killer cells

1992 • 130 citations

NK cell activation: distinct stimulatory pathways counterbalancing inhibitory signals

2000 • 130 citations

Kinetics of Interaction of HLA-C Ligands with Natural Killer Cell Inhibitory Receptors

1998 • 121 citations

Cutting Edge: KAP10, a Novel Transmembrane Adapter Protein Genetically Linked to DAP12 but with Unique Signaling Properties

1999 • 115 citations

Lymphokine activated killer cells

1989 • 113 citations

Physical and functional independency of p70 and p58 natural killer (NK) cell receptors for HLA class I: their role in the definition of different groups of alloreactive NK cell clones.

1996 • 112 citations

A Phase III randomized study of interleukin-2 lymphokine-activated killer cell immunotherapy combined with chemotherapy or radiotherapy after curative or noncurative resection of primary lung carcinoma

1997 • 106 citations

Paired inhibitory and triggering NK cell receptors for HLA class I molecules

2000 • 103 citations

The genomic organization of NKG2C , E , F , and D receptor genes in the human natural killer gene complex

1998 • 101 citations

Extended continuous infusion low-dose recombinant interleukin-2 in advanced cancer: prolonged immunomodulation without significant toxicity.

1991 • 101 citations

Genomic organization of a human killer cell inhibitory receptor gene

1997 • 98 citations

The activating form of CD94 receptor complex: CD94 covalently associated with the Kp39 protein that represents the product of the NKG2-C gene

1998 • 98 citations

2B4-mediated activation of human natural killer cells

2000 • 96 citations

Modification of P-selectin glycoprotein ligand-1 with a natural killer cell-restricted sulfated lactosamine creates an alternate ligand for L-selectin

2000 • 93 citations

Activating and Inhibitory NK Cell Receptors

1998 • 86 citations

Recognition of virus-infected cells by natural killer cell clones is controlled by polymorphic target cell elements.

1993 • 85 citations

Evaluation of natural killer cell expansion and activation in vivo with daily subcutaneous low-dose interleukin-2 plus periodic intermediate-dose pulsing

1998 • 83 citations

Immunology of human placental implantation: clinical implications of our current understanding

1997 • 82 citations

Functional heterogeneity of Leu 19"bright"+ and Leu 19"dim"+ lymphokine-activated killer cells.

1989 • 78 citations

Prolonged continuous intravenous infusion interleukin-2 and lymphokine-activated killer-cell therapy for metastatic renal cell carcinoma.

1992 • 75 citations

Immunobiology of natural killer cells and bone marrow transplantation: merging of basic and preclinical studies

2001 • 74 citations

Participation of the CD94 Receptor Complex in Costimulation of Human Natural Killer Cells

1998 • 73 citations

Genomic structure, chromosome location, and alternative splicing of the humanNKG2A gene

1996 • 68 citations

Genomic organization and allelic polymorphism of the human killer cell inhibitory receptor gene KIR 103

1997 • 65 citations

Graft‐versus‐leukaemia activity can be predicted by natural cytotoxicity against leukaemia cells

1996 • 61 citations

A pilot study of interleukin-2 for adult patients with acute myelogenous leukemia in first complete remission

1999 • 59 citations

Biochemical and serologic evidence for the existence of functionally distinct forms of the CD94 NK cell receptor.

1996 • 59 citations

Allogeneic MHC‐mismatched activated natural killer cells administered after bone marrow transplantation provide a strong graft‐versus‐leukaemia effect in mice

1997 • 56 citations

Continuous intravenous infusion of high-dose recombinant interleukin-2 for acute myeloid leukaemia — a phase II study

1992 • 56 citations

The UL16 gene of human cytomegalovirus encodes a glycoprotein that is dispensable for growth in vitro

1992 • 54 citations

The CD94/NKG2 C-Type Lectin Receptor Complex

1998 • 51 citations

Regulation of hematopoiesis in vitro by alloreactive natural killer cell clones.

1993 • 50 citations

HumanKLRF1, a novel member of the killer cell lectin-like receptor gene family: molecular characterization, genomic structure, physical mapping to the NK gene complex and expression analysis

2000 • 50 citations

Surface receptors delivering opposite signals regulate the function of human NK cells

2000 • 45 citations

The Epithelial Cellular Adhesion Molecule (EP-Cam) Is a Ligand for the Leukocyte-Associated Immunoglobulin-like Receptor (Lair)

2001 • 42 citations

Natural killer lectin-like receptors have divergent carboxyl-termini, distinct from C-type lectins

1994 • 40 citations

Lymphokine-activated killer (LAK) and monocyte-mediated cytotoxicity on tumor cell lines resistant to antitumor agents

1989 • 38 citations

Linkage of the NKG2 and CD94 receptor genes to D12S77 in the human natural killer gene complex

1999 • 34 citations

IFN increases class I MHC antigen expression on adenovirus-infected human cells without inducing resistance to natural killer cell killing.

1992 • 32 citations

High-Dose Regimen of Interleukin-2 and Interferon-Alpha in Combination with Lymphokine-Activated Killer Cells in Patients with Metastatic Renal Cell Cancer

1997 • 22 citations

Relationship between target cell cycle and susceptibility to natural killer lysis.

1987 • 18 citations