The Involvement of Tyrosine Kinases, Cyclic AMP/Protein Kinase A, and p38 Mitogen-Activated Protein Kinase in IL-13-Mediated Arginase I Induction in Macrophages: Its Implications in IL-13-Inhibited Nitric Oxide Production

Nitric oxide synthases: Roles, tolls, and controls

1994 • 2,945 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Regulation of biosynthesis of nitric oxide.

1994 • 1,698 citations

NO at work

1994 • 1,493 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine.

1993 • 832 citations

Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow‐derived macrophages by TH 1 and TH 2 cytokines

1995 • 553 citations

The high-output nitric oxide pathway: role and regulation

1994 • 512 citations

Arginase Induction by Suppressors of Nitric Oxide Synthesis (IL-4, IL-10 and PGE2) in Murine Bone-Marrow-Derived Macrophages

1995 • 358 citations

Arginase modulates nitric oxide production in activated macrophages

1998 • 302 citations

Differential regulation of arginases and inducible nitric oxide synthase in murine macrophage cells

1998 • 254 citations

Modulation of murine macrophage function by IL-13.

1993 • 251 citations

Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage‐like cell line

1996 • 238 citations

Coinduction of Nitric-oxide Synthase and Arginase I in Cultured Rat Peritoneal Macrophages and Rat Tissues in Vivo by Lipopolysaccharide

1997 • 215 citations

Co-induction of Arginase and Nitric Oxide Synthase in Murine Macrophages Activated by Lipopolysaccharide

1995 • 213 citations

Cloning and Characterization of the Human Type II Arginase Gene

1996 • 189 citations

Nitric Oxide Synthases: Gene Structure and Regulation

1995 • 189 citations

Transforming growth factor-beta stimulates arginase activity in macrophages. Implications for the regulation of macrophage cytotoxicity.

1995 • 186 citations

Role of nitric oxide in mediation of macrophage cytotoxicity and apoptosis.

1998 • 180 citations

Interleukin-13 Signal Transduction in Lymphohemopoietic Cells

1995 • 145 citations

IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling.

1996 • 141 citations

Regulation of mRNA levels for five urea cycle enzymes in rat liver by diet, cyclic AMP, and glucocorticoids

1987 • 126 citations

Identification and functional characterisation of the cellular activating transcription factor 43 (ATF-43) protein

1991 • 123 citations

Similarities and differences in signal transduction by interleukin 4 and interleukin 13: analysis of Janus kinase activation.

1995 • 118 citations

Regulation of the Expression of the Inducible Isoform of Nitric Oxide Synthase

1995 • 112 citations

Regulation of Messenger Ribonucleic Acid Levels for Five Urea Cycle Enzymes in Cultured Rat Hepatocytes. Requirements for Cyclic Adenosine Monophosphate, Glucocorticoids, and Ongoing Protein Synthesis

1988 • 98 citations

Regulation of arginase isoforms I and II by IL-4 in cultured murine peritoneal macrophages

1999 • 93 citations

Mechanism of suppression of macrophage nitric oxide release by IL-13: influence of the macrophage population.

1997 • 78 citations

Gene transfer with IL-4 and IL-13 improves survival in lethal endotoxemia in the mouse and ameliorates peritoneal macrophages immune competence

1998 • 73 citations

Regulation of Acute Lung Inflammatory Injury by Endogenous IL-13

1999 • 65 citations

Human liver-type arginase gene: structure of the gene and analysis of the promoter region

1988 • 63 citations

Inhibition of inducible nitric oxide synthase expression by interleukin‐4 and interleukin‐13 in human lung epithelial cells

1996 • 63 citations

The biology of macrophages: I General principles and properties

1993 • 60 citations

Regulation of Urea Synthesis in Rat Liver

1978 • 58 citations

Involvement of p38 Mitogen-activated Protein Kinase Signaling Pathway in the Rapid Induction of the 78-kDa Glucose-regulated Protein in 9L Rat Brain Tumor Cells

1998 • 48 citations

Review: Nitric Oxide, Sepsis, and Arginine Metabolism

1995 • 45 citations

Interleukin-13 inhibits inducible nitric oxide synthase expression in human mesangial cells

1996 • 44 citations

Arginase activity is modulated by IL-4 and HOArg in nephritic glomeruli and mesangial cells

1998 • 41 citations

Arginase distribution in tissues of domestic animals

1992 • 38 citations

Murine Th1 and Th2 cell clones differentially regulate macrophage nitric oxide production

1995 • 35 citations

Cloning of Rat Interleukin-13 (IL-13) cDNA and Analysis of IL-13 Gene Expression in Experimental Glomerulonephritis

1993 • 34 citations

Regulation of Urea Synthesis in Rat Liver

1979 • 27 citations

Evidence for a Tyrosine Kinase-Dependent Activation of the Adenylyl Cyclase/PKA Cascade Downstream from the G-Protein-Linked Endothelin ETA Receptor in Vascular Smooth Muscle

1998 • 18 citations

Macrophage-Mediated Cytotoxicity

1993 • 9 citations