Macrophage-Mediated Cytotoxicity

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Secretory products of macrophages.

1987 • 2,670 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Tumor Necrosis Factor (TNF)

1985 • 1,932 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

The Biology of Cachectin/TNF -- A Primary Mediator of the Host Response

1989 • 1,679 citations

Cachectin and tumour necrosis factor as two sides of the same biological coin

1986 • 1,659 citations

The Cell Biology of Macrophage Activation

1984 • 1,623 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF

1988 • 1,105 citations

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

1987 • 958 citations

Human tumor necrosis factor. Production, purification, and characterization.

1985 • 922 citations

Deactivation of macrophages by transforming growth factor-β

1988 • 876 citations

Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis

1990 • 871 citations

Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor

1989 • 821 citations

The two different receptors for tumor necrosis factor mediate distinct cellular responses.

1991 • 815 citations

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

1991 • 812 citations

Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, γ-interferon and interleukin-1

1986 • 781 citations

Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine.

1990 • 751 citations

Tumour necrosis factors α and β inhibit virus replication and synergize with interferons

1986 • 726 citations

Tumor necrosis factor Characterization at the molecular, cellular and in vivo level

1991 • 708 citations

Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism.

1990 • 690 citations

Macrophage Oxidation of L-Arginine to Nitric Oxide, Nitrite, and Nitrate

1989 • 681 citations

Tumor necrosis factor.

1992 • 601 citations

Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.

1988 • 592 citations

Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine.

1990 • 573 citations

N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.

1991 • 572 citations

Reduced Biopterin as a Cofactor in the Generation of Nitrogen Oxides by Murine Macrophages

1989 • 571 citations

Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity.

1979 • 538 citations

Tumor necrosis factor-alpha synergizes with IFN-gamma in mediating killing of Leishmania major through the induction of nitric oxide.

1990 • 531 citations

Structure of tumour necrosis factor

1989 • 512 citations

EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages.

1990 • 512 citations

Interferon‐γ and tumor necrosis factor induce the L‐arginine‐dependent cytotoxic effector mechanism in murine macrophages^*

1988 • 511 citations

Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma.

1990 • 507 citations

Identification of a membrane-associated interleukin 1 in macrophages.

1985 • 487 citations

The discovery of nitric oxide as the endogenous nitrovasodilator.

1988 • 486 citations

Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide.

1989 • 464 citations

Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs ¹

1991 • 461 citations

Recombinant mouse gamma interferon induces the priming step in macrophage activation for tumor cell killing.

1983 • 447 citations

Mechanism of Immunologically Specific Killing of Tumour Cells by Macrophages

1972 • 435 citations

The active form of tumor necrosis factor is a trimer.

1987 • 430 citations

Extracellular cytolysis by activated macrophages and granulocytes. I. Pharmacologic triggering of effector cells and the release of hydrogen peroxide.

1979 • 423 citations

Nitric oxide: biosynthesis and biological significance

1989 • 421 citations

Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible.

1986 • 421 citations

A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contact

1990 • 409 citations

Antiviral effects of recombinant tumour necrosis factor in vitro

1986 • 392 citations

Human interleukin 1 is a cytocidal factor for several tumor cell lines.

1985 • 380 citations

Cell-associated tumor necrosis factor (TNF) as a killing mechanism of activated cytotoxic macrophages.

1987 • 361 citations

Tumor necrosis factor: a potent effector molecule for tumor cell killing by activated macrophages.

1986 • 360 citations

Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages.

1990 • 356 citations

Macrophages and metastasis--a biological approach to cancer therapy.

1985 • 354 citations

In vivo recognition and clearance of red blood cells containing phosphatidylserine in their plasma membranes.

1985 • 352 citations

A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia.

1991 • 348 citations

Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages.

1988 • 337 citations

Molecular mechanisms of signal transduction in macrophages

1987 • 331 citations

Eradication of spontaneous metastases and activation of alveolar macrophages by intravenous injection of liposomes containing muramyl dipeptide.

1981 • 322 citations

Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates.

1989 • 320 citations

Intracellular localization of human monocyte associated interleukin 1 (IL 1) activity and release of biologically active IL 1 from monocytes by trypsin and plasmin.

1986 • 318 citations

Role of early region 3 (E3) in pathogenesis of adenovirus disease.

1989 • 285 citations

Macrophages and Age-Dependent Resistance to Herpes Simplex Virus in Mice

1970 • 282 citations

Heterocytolysis by Macrophages Activated by Bacillus Calmette-Gurin: Lysosome Exocytosis into Tumor Cells

1974 • 278 citations

Molecular Transductional Mechanisms by which IFNγ and Other Signals Regulate Macrophage Development

1987 • 266 citations

A 14,700 MW protein from the E3 region of adenovirus inhibits cytolysis by tumor necrosis factor

1988 • 251 citations

L-citrulline production from L-arginine by macrophage nitric oxide synthase. The ureido oxygen derives from dioxygen.

1990 • 240 citations

Macrophage-mediated tumor cell killing: regulation of expression of cytolytic activity by prostaglandin E.

1981 • 238 citations

Cytolytic mechanisms of activated macrophages. Tumor necrosis factor and L-arginine-dependent mechanisms act synergistically as the major cytolytic mechanisms of activated macrophages.

1990 • 237 citations

IL-4 inhibits H2O2 production and antileishmanial capacity of human cultured monocytes mediated by IFN-gamma.

1989 • 228 citations

Insertion of fluorescent phosphatidylserine into the plasma membrane of red blood cells. Recognition by autologous macrophages.

1983 • 220 citations

Regulation of Macrophage Tumoricidal Function: A Role for Prostaglandins of the E Series

1978 • 214 citations

IL-4 inhibits superoxide production by human mononuclear phagocytes.

1990 • 211 citations

Peptides encoded by the calcitonin gene inhibit macrophage function.

1989 • 208 citations

Natural and recombinant human interleukin 1-beta is cytotoxic for human melanoma cells.

1986 • 207 citations

Effector mechanisms of cytolytically activated macrophages. II. Secretion of a cytolytic factor by activated macrophages and its relationship to secreted neutral proteases.

1980 • 206 citations

Effector mechanisms of cytolytically activated macrophages. I. Secretion of neutral proteases and effect of protease inhibitors.

1980 • 194 citations

Tumor necrosis factor is an important mediator of tumor cell killing by human monocytes.

1987 • 192 citations

Discrimination Between Neoplastic and Non-Neoplastic Cells In Vitro by Activated Macrophages12

1974 • 191 citations

Recognition and destruction of neoplastic cells by activated macrophages: discrimination of altered self

1988 • 186 citations

Iron depletion: Possible cause of tumor cell cytotoxicity induced by activated macrophages

1984 • 183 citations

FAD and GSH participate in macrophage synthesis of nitric oxide

1990 • 182 citations

L-arginine-dependent macrophage effector functions inhibit metabolic activity of Mycobacterium leprae.

1991 • 180 citations

Activation of mouse macrophages for tumor cell killing. I. Quantitative analysis of interactions between lymphokine and lipopolysaccharide.

1981 • 172 citations

An Inhibitor of Macrophage Chemotaxis Produced by Neoplasms

1976 • 165 citations

Macrophage activation for tumor cytotoxicity: characterization of priming and trigger signals during lymphokine activation.

1981 • 154 citations

Synthesis of nitrogen oxides from L-arginine by macrophage cytosol: Requirement for inducible and constitutive components

1989 • 148 citations

Role of the Myeloperoxidase-H2O2-Halide System in Concanavalin A-Induced Tumor Cell Killing by Human Neutrophils

1979 • 142 citations

Activation of tumoricidal properties in mouse macrophages by lymphokines encapsulated in liposomes.

1979 • 136 citations

VIRUSES AND THE VERSATILE MACROPHAGE

1985 • 136 citations

Stimulated macrophages express a new glycoprotein receptor reactive with Griffonia simplicifolia I-B4 isolectin.

1982 • 135 citations

Molecular mechanisms in tumor-cell killing by activated macrophages

1983 • 127 citations

Adenovirus E1A renders infected cells sensitive to cytolysis by tumor necrosis factor.

1989 • 125 citations

Induction by E1A oncogene expression of cellular susceptibility to lysis by TNF

1987 • 124 citations

Activation of mouse peritoneal macrophages by lipopolysaccharide alters the kinetic parameters of the superoxide-producing NADPH oxidase.

1983 • 120 citations

Inhibitors of monocyte responses to chemotaxins are present in human cancerous effusions and react with monoclonal antibodies to the P15(E) structural protein of retroviruses.

1981 • 119 citations

Evidence for the existence of two forms of membrane tumor necrosis factor: an integral protein and a molecule attached to its receptor.

1989 • 119 citations

Subcellular localization of human monocyte interleukin 1: evidence for an inactive precursor molecule and a possible mechanism for IL 1 release.

1987 • 118 citations

The myeloperoxidase-hydrogen peroxide-halide system as effector of neutrophil-mediated tumor cell cytotoxicity.

1981 • 116 citations

Localization of human mononuclear cell interleukin 1.

1987 • 116 citations

Morphological evidence for the translocation of lysosomal organelles from cytotoxic macrophages into the cytoplasm of tumor target cells.

1976 • 115 citations

Receptors for Maleylated Proteins Regulate Secretion of Neutral Proteases by Murine Macrophages

1982 • 112 citations

Macrophages and cancer

1990 • 109 citations

Molecular basis for the enhanced respiratory burst of activated macrophages.

1985 • 104 citations

A noncytotoxic mast cell tumor line exhibits potent IgE-dependent cytotoxicity after transfection with the cytolysin/perforin gene

1991 • 104 citations

Immunohistochemical demonstration of cytoplasmic and membrane-associated tumor necrosis factor in murine macrophages.

1988 • 101 citations

A potential role for hypochlorous acid in granulocyte-mediated tumor cell cytotoxicity

1980 • 95 citations

Tumor necrosis factor as effector molecule in monocyte mediated cytotoxicity.

1986 • 89 citations

Processing of newly synthesized cachectin/tumor necrosis factor in endotoxin-stimulated macrophages

1990 • 86 citations

Recognition and destruction of target cells by tumoricidal macrophages.

1978 • 86 citations

Lymphokine-activated human blood monocytes destroy tumor cells but not normal cells under cocultivation conditions.

1984 • 82 citations

Tumor Necrosis Factor and Lymphotoxin Secretion by Human Natural Killer Cells Leads to Antiviral Cytotoxicity

2015 • 80 citations

Suppression of macrophage oxidative metabolism by products of malignant and nonmalignant cells.

1982 • 75 citations

The recognition of red blood cells by macrophages: role of phosphatidylserine and possible implications of membrane phospholipid asymmetry

1984 • 75 citations

Cellular models of macrophage tumoricidal effector mechanisms in vitro. Characterization of cytolytic responses to tumor necrosis factor and nitric oxide pathways in vitro.

1991 • 72 citations

Activation of tumoricidal properties in monocytes from cancer patients following intravenous administration of liposomes containing muramyl tripeptide phosphatidylethanolamine.

1989 • 72 citations

Endocytic pathway of recombinant murine tumor necrosis factor in L-929 cells.

1988 • 71 citations

Human Monocytes Activated by Immunomodulators in Liposomes Lyse Herpesvirus-Infected But Not Normal Cells

1984 • 71 citations

Use of monoclonal antibodies to a human cytotoxin for its isolation and for examining the self-induction of resistance to this protein.

1985 • 71 citations

Macrophage tumor necrosis factor-alpha release is induced by contact with some tumors.

1990 • 70 citations

Interaction of Bacillus Calmette-Guérin-activated macrophages and neoplastic cells in vitro

1980 • 69 citations

Plasma membrane-associated tumor necrosis factor. A non-integral membrane protein possibly bound to its own receptor.

1988 • 69 citations

In vivo and in vitro expression of macrophage membrane interleukin 1 in response to soluble and particulate stimuli.

1986 • 68 citations

On the role of mononuclear phagocytes in immunity against viruses.

1974 • 64 citations

Gene Regulation in Macrophage Activation: Differential Regulation of Genes Encoding for Tumor Necrosis Factor, Interleukin-1, JE, and KC by interferon-γ and Lipopolysaccharide

1990 • 63 citations

Activation of mouse peritoneal macrophages by monoclonal antibodies to Mac-1 (complement receptor type 3).

1987 • 62 citations

Tumor necrosis factor and IL-1 associated with plasma membranes of activated human monocytes lyse monokine-sensitive but not monokine-resistant tumor cells whereas viable activated monocytes lyse both.

1988 • 60 citations

Tumor necrosis factor and lymphotoxin secretion by human natural killer cells leads to antiviral cytotoxicity.

1988 • 58 citations

Effects of bacterial lipopolysaccharide on protein synthesis in murine peritoneal macrophages: Relationship to activation for macrophage tumoricidal function

1986 • 58 citations

Hydrogen peroxide and cytolytic factor can interact synergistically in effecting cytolysis of neoplastic targets.

1981 • 57 citations

Constitutive production and release of a lymphokine with macrophage-activating factor activity distinct from gamma-interferon by a human T-cell leukemia virus-positive cell line.

1984 • 56 citations

Activated Macrophage Conditioned Medium: Identification of the Soluble Factors Inducing Cytotoxicity and the L-Arginine Dependent Effector Mechanism

1991 • 56 citations

Ultrastructural studies of the interaction between liposome-activated human blood monocytes and allogeneic tumor cells in vitro.

1983 • 54 citations

Interaction of Bacillus Calmette-Guérin-activated macrophages and neoplastic cells in vitro

1980 • 53 citations

Requirement for the continual presence of lipopolysaccharide for production of tumor necrosis factor by thioglycollate‐induced peritoneal murine macrophages

1986 • 52 citations

Adenovirus E1A gene induction of susceptibility to lysis by natural killer cells and activated macrophages in infected rodent cells

1987 • 52 citations

Selection of macrophage-resistant progressor tumor variants by the normal host. Requirement for concomitant T cell-mediated immunity.

1983 • 51 citations

Activation of the cAMP cascade inhibits an early event involved in murine macrophage Ia expression.

1990 • 49 citations

Molecular events in the activation of murine macrophages

1989 • 49 citations

Macrophage deactivation. Altered kinetic properties of superoxide-producing enzyme after exposure to tumor cell-conditioned medium.

1986 • 48 citations

Role of tumor necrosis factor-alpha in E1A oncogene-induced susceptibility of neoplastic cells to lysis by natural killer cells and activated macrophages.

1989 • 47 citations

Recent developments concerning muramyl dipeptide, a synthetic immunoregulating molecule.

1979 • 47 citations

Resistance of tumor cells to tumor necrosis factor

1988 • 45 citations

Cytotoxicity of alveolar macrophages for virus-infected cells

1975 • 40 citations

In vitro tumoricidal activity of macrophages against virus-transformed lines with temperature-dependent transformed phenotypic characteristics

1978 • 39 citations

DNA virus‐transformed hamster cell – host effector cell interactions: Level of resistance to cytolysis correlated with tumorigenicity

1982 • 39 citations

Detection of IL-1 alpha and IL-1 beta in the supernatants of paraformaldehyde-treated human monocytes. Evidence against a membrane form of IL-1.

1990 • 39 citations

The capacity of activated murine macrophages for augmented binding of neoplastic cells: analysis of induction by lymphokine containing MAF and kinetics of the reaction.

1982 • 38 citations

Differential induction of activation markers in macrophage cell lines by interferon-γ

1989 • 37 citations

Comparison of transforming growth factor-beta and a macrophage- deactivating polypeptide from tumor cells. Differences in antigenicity and mechanism of action.

1989 • 37 citations

The binding of tumor cells by murine mononuclear phagocytes can be divided into two qualitatively distinct types.

1983 • 36 citations

The relationship between competence for secretion of H2O2 and completion of tumor cytotoxicity by BCG-elicited murine macrophages.

1982 • 35 citations

Role of the maleyl-albumin receptor in activation of murine peritoneal macrophages in vitro.

1989 • 35 citations

MIF-Like Activity in Simian Virus 40-Transformed 3T3 Fibroblast Cultures

1974 • 34 citations

Transforming growth factor-β1 inhibits activation of macrophage cell line RAW 264.7 for cell killing

1990 • 34 citations

Membrane-associated interleukin 1 alpha as a mediator of tumor cell killing by human blood monocytes fixed with paraformaldehyde.

1989 • 34 citations

Evidence for Mononuclear Phagocytes in Solid Neoplasms and Appraisal of Their Nonspecific Cytotoxic Capabilities

1980 • 34 citations

Purification of macrophage deactivating factor.

1990 • 33 citations

Quantification of the strength of cell-cell adhesion: the capture of tumor cells by activated murine macrophages proceeds through two distinct stages.

1986 • 32 citations

IFN-gamma differentially modulates the susceptibility of L1210 and P815 tumor targets for macrophage-mediated cytotoxicity. Role of macrophage-target interaction coupled to nitric oxide generation, but independent of tumor necrosis factor production.

1991 • 32 citations

Variation in selectivity of tumor cell cytolysis by murine macrophages, macrophage-like cell lines and NK cells

1982 • 31 citations

Identification and characterization of monoclonal antibodies specific for macrophages at intermediate stages in the tumoricidal activation pathway.

1990 • 30 citations

Lysis of herpesvirus-infected cells by macrophages activated with free or liposome-encapsulated lymphokine produced by a murine T cell hybridoma

1983 • 30 citations

Inducible Macrophage Cytotoxins. II. Tumor Lysis Mechanism Involving Target Cell-Binding Proteases<xref ref-type="fn" rid="FN2">2</xref>

1982 • 30 citations

Inhibition of NK and ADCC Activity by Antibodies Against Purified Cytoplasmic Granules From Rat LGL Tumors

1987 • 28 citations

Alterations in Sensitivity to Nonspecific Cell-Mediated Lysis Associated With Tumor Progression: Characterization of Activated Macrophage- and Natural Killer Cell-Resistant Tumor Variants23

1984 • 28 citations

Resistance of simian virus 40-transformed hamster cells to the cytolytic effect of activated macrophages: a possible factor in species-specific viral oncogenicity.

1980 • 28 citations

IFN-gamma potentiates the accumulation of diacylglycerol in murine macrophages.

1990 • 25 citations

Deactivation of the respiratory burst in activated macrophages: evidence for alteration of signal transduction.

1986 • 25 citations

Evidence for the involvement of cytolytic macrophages in rejection of SV40-induced tumors.

1985 • 24 citations

Potent in situ activation of murine lung macrophages and therapy of melanoma metastases by systemic administration of liposomes containing muramyltripeptide phosphatidylethanolamine and interferon gamma.

1989 • 24 citations

Production of lymphokine-like factors (cytokines) by simian virus 40-infected and simian virus 40-transformed cells.

1975 • 24 citations

Comparison of recombinant tumor necrosis factor and the monocyte-derived cytotoxic factor involved in monocyte-mediated cytotoxicity.

1987 • 23 citations

Comparative efficacy of liposomes containing synthetic bacterial cell wall analogues for tumoricidal activation of monocytes and macrophages

1991 • 21 citations

Tumoricidal Effector Mechanisms of Murine BCG-Activated Macrophages: Role of TNF in Conjugation-Dependent and Conjugation-Independent Pathways

1990 • 21 citations

Comparison of Five Short-Term Assays That Measure Nonspecific Cytotoxicity Mediated to Tumor Cells by Activated Macrophages

1986 • 19 citations

An adherent cell lyses virus-infected targets: characterization, activation, and fine specificity of the cytotoxic cell.

1982 • 17 citations

In situ activation of mouse macrophages and therapy of spontaneous renal cell cancer metastasis by liposomes containing the lipopeptide CGP 31362

1991 • 15 citations

Macrophage Activation for Cytolysis of Virally Infected Target Cells

1989 • 15 citations

Therapy of spontaneous lung metastasis of murine renal adenocarcinoma by systemic administration of liposomes containing the macrophage activator CGP 31362.

1991 • 14 citations

Activation of Macrophages by Peroxidases

1986 • 13 citations

Tumor necrosis factor-mediated cytotoxicity by tumor-associated macrophages

1989 • 13 citations

Genetic aspects of macrophage involvement in natural resistance to virus infections

1985 • 12 citations

Peroxidases Enhance Macrophage-Mediated Cytotoxicity Via Induction of Tumor Necrosis Factor

1989 • 10 citations

Target-induced changes in macrophage migration may explain differences in lytic sensitivity among simian virus 40-transformed fibroblasts.

1988 • 10 citations

A differential interaction in vitro of mouse macrophages with normal lymphocytes and malignant lymphoma cells

1977 • 10 citations

Prostaglandin E2 does not inhibit tumoricidal activity of mouse macrophages against adherent tumor cells.

1991 • 10 citations

Maleylated bovine serum albumin triggers cytolytic function in selected populations of primed murine macrophages.

1987 • 10 citations

The incubation of human blood monocytes with tumor necrosis factor-α leads to lysis of tumor necrosis factor-sensitive but not resistant tumor cells

1990 • 8 citations

Activation of Murine Mononuclear Phagocytes for Destroying Tumor Cells: Analysis of Effector Mechanisms and Development

1982 • 7 citations

Human Monocyte-Mediated Cytotoxicity Against Herpes Simplex Virus-Infected Cells: Activation of Cytotoxic Monocytes by Free and Liposome-Encapsulated Lymphokines

1985 • 7 citations

L-Arginine independent macrophage tumor cytotoxicity

1989 • 5 citations

Evidence that a target-derived soluble factor is necessary for the selective lysis of SV40-transformed fibroblasts by activated mouse macrophages.

1990 • 4 citations