Arginase modulates nitric oxide production in activated macrophages

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Nitric oxide synthases: Roles, tolls, and controls

1994 • 2,945 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine.

1993 • 832 citations

Comparative properties of arginases

1996 • 604 citations

New insights into the regulation of inducible nitric oxide synthesis

1994 • 582 citations

Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow‐derived macrophages by TH 1 and TH 2 cytokines

1995 • 553 citations

Determination of arginase activity in macrophages: a micromethod

1994 • 536 citations

Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages.

1990 • 356 citations

Temporal expression of different pathways of 1-arginine metabolism in healing wounds.

1990 • 351 citations

THE INHIBITION OF ARGINASE BY AMINO ACIDS

1945 • 327 citations

Activated macrophages kill tumour cells by releasing arginase

1978 • 307 citations

Macrophages can convert citrulline into arginine

1992 • 217 citations

Coinduction of Nitric-oxide Synthase and Arginase I in Cultured Rat Peritoneal Macrophages and Rat Tissues in Vivo by Lipopolysaccharide

1997 • 215 citations

Co-induction of Arginase and Nitric Oxide Synthase in Murine Macrophages Activated by Lipopolysaccharide

1995 • 213 citations

Macrophage arginine metabolism and the inhibition or stimulation of cancer.

1992 • 192 citations

Transforming growth factor-beta stimulates arginase activity in macrophages. Implications for the regulation of macrophage cytotoxicity.

1995 • 186 citations

Rat Liver Arginase: Kinetic Mechanism, Alternate Substrates, and Inhibitors

1994 • 168 citations

Regulation and Function of Inducible Nitric Oxide Synthase during Sepsis and Acute Inflammation

1995 • 154 citations

An Inhibitor of Macrophage Arginine Transport and Nitric Oxide Production (CNI-1493) Prevents Acute Inflammation and Endotoxin Lethality

1995 • 116 citations

Regulation of the Expression of the Inducible Isoform of Nitric Oxide Synthase

1995 • 112 citations

Arginine metabolism in experimental glomerulonephritis: interaction between nitric oxide synthase and arginase

1994 • 61 citations

The role of arginase in the immune response

1985 • 58 citations

<scp>l</scp>‐Arginine depletion by arginase reduces nitric oxide production in endotoxic shock: an electron paramagnetic resonance study

1995 • 56 citations

Sources of ammonia for urea synthesis in isolated rat liver cells

1977 • 44 citations

Beneficial Circulatory Effect of L-Arginine

1994 • 36 citations

Alteration in IL-1 and arginase activity of tumor-associated macrophages: a role in the promotion of tumor growth

1996 • 34 citations

Arginine supply for nitric oxide synthesis and arginase is mainly exogenous in elicited murine and rat macrophages

1994 • 30 citations

Stimulation of peritoneal cell arginase by bacterial lipopolysaccharides.

1980 • 29 citations

Regulation of Urea Synthesis in Rat Liver

1979 • 27 citations

The macrophage response to bacteria: Flow of L-arginine through the nitric oxide and urea pathways and induction of tumoricidal activity

1991 • 25 citations

Computer-aided comparison of the inhibition of arginase and nitric oxide synthase in macrophages by amino acids not related to arginine

1996 • 24 citations

Studies on Rat Liver Argininosuccinate Synthetase Inhibition by Various Amino Acids

1979 • 20 citations

The effects of endotoxin administration on blood amino acid concentrations: similarities with sepsis.

1993 • 20 citations

An enzymatic route to l-ornithine from arginine—activation, selectivity and stabilization of l-arginase

1994 • 18 citations

Glycogenesis from glucose and ureagenesis in isolated perfused rat livers. Influence of ammonium ion, norvaline, and ethoxyzolamide.

1994 • 15 citations

Arginase inhibition

1981 • 12 citations

Deleted Work

1955 • 0 citations