Gene transfer with IL-4 and IL-13 improves survival in lethal endotoxemia in the mouse and ameliorates peritoneal macrophages immune competence

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

1993 • 1,719 citations

Structure and Function of Lipopolysaccharide Binding Protein

1990 • 1,689 citations

Treatment of Septic Shock with the Tumor Necrosis Factor Receptor:Fc Fusion Protein

1996 • 1,217 citations

lnterleukin-13 is a new human lymphokine regulating inflammatory and immune responses

1993 • 877 citations

Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10.

1993 • 657 citations

Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction.

1993 • 457 citations

Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis

1993 • 427 citations

Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin.

1991 • 279 citations

The Primary Binding Subunit of the Human Interleukin-4 Receptor Is Also a Component of the Interleukin-13 Receptor

1995 • 236 citations

An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors.

1993 • 219 citations

Species-specificity of T cell stimulating activities of IL 2 and BSF-1 (IL 4): comparison of normal and recombinant, mouse and human IL 2 and BSF-1 (IL 4).

1987 • 161 citations

Interleukin 4 down‐regulates the expression of CD14 in normal human monocytes

1990 • 158 citations

In vivo gene delivery. Efficient transfection of T lymphocytes in adult mice

1993 • 129 citations

Similarities and differences in signal transduction by interleukin 4 and interleukin 13: analysis of Janus kinase activation.

1995 • 118 citations

Human tumor necrosis factor receptor (p55) and interleukin 10 gene transfer in the mouse reduces mortality to lethal endotoxemia and also attenuates local inflammatory responses.

1995 • 102 citations

IL-13 down-regulates CD14 expression and TNF-alpha secretion in normal human monocytes.

1995 • 90 citations

Protection against lethal Escherichia coli bacteremia in baboons (Papio anubis) by pretreatment with a 55-kDa TNF receptor (CD120a)-Ig fusion protein, Ro 45-2081.

1996 • 58 citations

Tolerance to Lipopolysaccharide in Human Blood Monocytes

1995 • 56 citations

Interleukin 1 binding to its type I, but not type II receptor, modulates the in vivo acute phase response

1995 • 34 citations

The role of bactericidal/permeability-increasing protein in the treatment of primate bacteremia and septic shock

1994 • 24 citations