Structure, Function and Evolution of Solute Transporters in Prokaryotes and Eukaryotes

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid

1993 • 2,625 citations

Analysis of membrane and surface protein sequences with the hydrophobic moment plot

1984 • 2,234 citations

Appearance of Water Channels in Xenopus Oocytes Expressing Red Cell CHIP28 Protein

1992 • 1,979 citations

The Metabolic Basis of Inherited Diseases

1972 • 1,762 citations

Sequence and Structure of a Human Glucose Transporter

1985 • 1,557 citations

Prevention of Drug Access to Bacterial Targets: Permeability Barriers and Active Efflux

1994 • 1,518 citations

Crystal structures explain functional properties of two E. coli porins

1992 • 1,493 citations

Primary structure and functional characterization of a high-affinity glutamate transporter

1992 • 1,319 citations

Cloning and expression of a rat brain L-glutamate transporter

1992 • 1,230 citations

Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain.

1992 • 1,185 citations

Cloning and expression of apical membrane water channel of rat kidney collecting tubule

1993 • 1,002 citations

Expression cloning and cDNA sequencing of the Na+/glucose co-transporter

1987 • 995 citations

Expression cloning of a cocaine-and antidepressant-sensitive human noradrenaline transporter

1991 • 928 citations

Expression cloning of a mammalian proton-coupled oligopeptide transporter

1994 • 880 citations

Cloning and Expression of a Rat Brain GABA Transporter

1990 • 873 citations

Cloning and expression of a functional serotonin transporter from rat brain

1991 • 822 citations

Membrane transport and metabolism

1961 • 774 citations

The herbicide sensitivity gene CHL1 of arabidopsis encodes a nitrate-inducible nitrate transporter

1993 • 751 citations

The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins

1993 • 695 citations

Aquaporin CHIP: the archetypal molecular water channel

1993 • 670 citations

The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose.

1994 • 598 citations

A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter

1992 • 594 citations

Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney

1994 • 591 citations

Cloning and Expression of a Cocaine-Sensitive Rat Dopamine Transporter

1991 • 587 citations

Cloning and Expression of a Cocaine-Sensitive Dopamine Transporter Complementary DNA

1991 • 584 citations

The Na,K-ATPase

1992 • 552 citations

Expression cloning of a reserpine-sensitive vesicular monoamine transporter.

1992 • 481 citations

Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system.

1991 • 479 citations

Isolation and characterization of a sucrose carrier cDNA from spinach by functional expression in yeast.

1992 • 479 citations

Cloning and expression of a glycine transporter reveal colocalization with NMDA receptors

1992 • 428 citations

Evidence for an essential role of the sucrose transporter in phloem loading and assimilate partitioning.

1994 • 418 citations

Structure of the Tet Repressor-tetracycline Complex and Regulation of Antibiotic Resistance

1994 • 407 citations

Mammalian and bacterial sugar transport proteins are homologous

1987 • 400 citations

Cloning of a Na(+)- and Cl(-)-dependent betaine transporter that is regulated by hypertonicity.

1992 • 393 citations

Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family

1993 • 387 citations

THE BACTERIAL PHOSPHOENOL-PYRUVATE: GLYCOSE PHOSPHOTRANSFERASE SYSTEM

1990 • 387 citations

Glucose/galactose malabsorption caused by a defect in the Na+/glucose cotransporter

1991 • 373 citations

The glial cell glutamate uptake carrier countertransports pH-changing anions

1992 • 372 citations

Cystinuria caused by mutations in rBAT, a gene involved in the transport of cystine

1994 • 368 citations

Porins and specific diffusion channels in bacterial outer membranes.

1994 • 367 citations

Proton-Coupled Sugar and Amino Acid Transporters in Plants

1993 • 359 citations

Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter.

1994 • 346 citations

Selectivity of MHC-encoded peptide transporters from human, mouse and rat

1994 • 339 citations

Cloning of the cDNa for a Na+/myo-inositol cotransporter, a hypertonicity stress protein.

1992 • 336 citations

Substrate specificity and transport properties of the glycerol facilitator of Escherichia coli

1980 • 321 citations

Three-dimensional structures of the periplasmic lysine/arginine/ornithine-binding protein with and without a ligand

1993 • 313 citations

Cloning and characterization of the vasopressin-regulated urea transporter

1993 • 299 citations

Cloning and expression of a cDNA encoding the transporter of taurine and beta-alanine in mouse brain.

1992 • 276 citations

Cloning and characterization of a second member of the mouse mdr gene family.

1988 • 268 citations

Hinge-bending in L-arabinose-binding protein. The “Venus's-flytrap” model.

1982 • 263 citations

Cloning and expression of a high affinity taurine transporter from rat brain.

1992 • 261 citations

Strategies of Phloem Loading

1993 • 259 citations

The high affinity Na+/glucose cotransporter. Re-evaluation of function and distribution of expression.

1994 • 256 citations

Specificity of diffusion channels produced by lambda phage receptor protein of Escherichia coli.

1980 • 251 citations

A binding protein-dependent transport system in Streptococcus mutans responsible for multiple sugar metabolism.

1992 • 240 citations

Molecular cloning and expression of a high affinity l -proline transporter expressed in putative glutamatergic pathways of rat brain

1992 • 239 citations

A new family of neurotransmitter transporters: the high‐affinity glutamate transporters

1993 • 228 citations

Cloning of a rat kidney cDNA that stimulates dibasic and neutral amino acid transport and has sequence similarity to glucosidases.

1992 • 222 citations

Expression cloning of a cDNA from rabbit kidney cortex that induces a single transport system for cystine and dibasic and neutral amino acids.

1992 • 221 citations

Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters

1993 • 219 citations

The aquaporin family of molecular water channels.

1994 • 216 citations

Transport Proteins in Bacteria: Common Themes in Their Design

1992 • 200 citations

Expression cloning of a Na(+)-independent neutral amino acid transporter from rat kidney.

1992 • 197 citations

The elusive transporters with a high affinity for glutamate

1993 • 195 citations

The Mitochondrial Carrier Family of Transport Proteins: Structural, Functional, and Evolutionary Relationships

1993 • 170 citations

Cloning and functional expression of a mammalian Na+/nucleoside cotransporter. A member of the SGLT family.

1992 • 163 citations

Membrane defence against complement lysis: The structure and biological properties of CD59

1993 • 162 citations

The hexose carrier from Chlorella

1989 • 154 citations

Stimulation of system y(+)-like amino acid transport by the heavy chain of human 4F2 surface antigen in Xenopus laevis oocytes.

1992 • 145 citations

The insect V-ATPase, a plasma membrane proton pump energizing secondary active transport: molecular analysis of electrogenic potassium transport in the tobacco hornworm midgut

1992 • 138 citations

Cloning and expression of a mammalian Na+/amino acid cotransporter with sequence similarity to Na+/glucose cotransporters.

1993 • 136 citations

Cloning a plant amino acid transporter by functional complementation of a yeast amino acid transport mutant.

1993 • 135 citations

Expression cloning of a human renal cDNA that induces high affinity transport of L-cystine shared with dibasic amino acids in Xenopus oocytes

1993 • 135 citations

Positively charged residues are important determinants of membrane protein topology

1990 • 132 citations

The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport.

1994 • 132 citations

Cloning and chromosomal localization of a human kidney cDNA involved in cystine, dibasic, and neutral amino acid transport.

1993 • 131 citations

Localization of a gene causing cystinuria to chromosome 2p

1994 • 122 citations

Identification and sequence analysis of the Rhizobium meliloti dctA gene encoding the C4-dicarboxylate carrier

1989 • 122 citations

The 4F2 antigen heavy chain induces uptake of neutral and dibasic amino acids in Xenopus oocytes.

1992 • 120 citations

Sodium-Coupled Neurotransmitter Transport: Structure, Function And Regulation

1994 • 113 citations

The transport of neurotransmitters into synaptic vesicles

1992 • 113 citations

Unidirectional fluxes of rhodamine 123 in multidrug-resistant cells: evidence against direct drug extrusion from the plasma membrane.

1994 • 111 citations

Nucleotide sequence of putP, the proline carrier gene of Escherichia coli K12

1987 • 108 citations

Primary structure and functional expression of a choline transporter expressed in the rat nervous system

1992 • 105 citations

Nucleotide sequence of gltS, the Na+/glutamate symport carrier gene of Escherichia coli B.

1990 • 100 citations

Lipopolysaccharide structure required for in vitro trimerization of Escherichia coli OmpF porin

1991 • 99 citations

Cloning, sequence, and expression of the pantothenate permease (panF) gene of Escherichia coli

1990 • 92 citations

Electrogenicity, pH-Dependence, and Stoichiometry of the Proton-Sucrose Symport

1990 • 88 citations

The Molecular Basis of Chloride Transport in Shark Rectal Gland

1994 • 85 citations

A 62-kD sucrose binding protein is expressed and localized in tissues actively engaged in sucrose transport.

1992 • 85 citations

Facilitated diffusion of p-nitrophenyl-alpha-D-maltohexaoside through the outer membrane of Escherichia coli. Characterization of LamB as a specific and saturable channel for maltooligosaccharides.

1988 • 79 citations

A New Family of Proteins (rBAT and 4F2hc) Involved in Cationic and Zwitterionic Amino Acid Transport: a Tale of Two Proteins in Search of a Transport Function

1994 • 79 citations

Revised nucleotide sequence of the gltP gene, which encodes the proton-glutamate-aspartate transport protein of Escherichia coli K-12

1992 • 74 citations

The vasopressin-regulated urea transporter in renal inner medullary collecting duct

1990 • 72 citations

Amino acid transport systems in intestinal brush-border membranes from lepidopteran larvae

1989 • 67 citations

K+/H+ Antiport in the Tobacco Hornworm Midgut: the K+-Transporting Component of the K+ Pump

1994 • 66 citations

A mitochondrial porin cDNA predicts the existence of multiple human porins

1993 • 66 citations

Expression of mRNA (D2) encoding a protein involved in amino acid transport in S3 proximal tubule

1992 • 62 citations

Relationships between rhodamine 123 transport, cell volume, and ion-channel function of P-glycoprotein.

1994 • 59 citations

The mannose transporter of Escherichia coli. Structure and function of the IIABMan subunit.

1993 • 57 citations

Assignment of the Gene Coding for the Human High-Affinity Glutamate Transporter EAAC1 to 9p24: Potential Role in Dicarboxylic Aminoaciduria and Neurodegenerative Disorders

1994 • 57 citations

Concentration dependence of urea and thiourea transport in rat inner medullary collecting duct

1990 • 53 citations

Asymmetric distribution of the plasma-membrane H+-ATPase in embryos of Vicia faba L. with special reference to transfer cells

1994 • 51 citations

Effects of dietary protein restriction and glucocorticoid administration on urea excretion in rats

1975 • 48 citations

Biophysical properties of porin pores from mitochondrial outer membrane of eukaryotic cells

1990 • 47 citations

Cation-dependent leucine, alanine, and phenylalanine uptake at pH 10 in brush-border membrane vesicles from larval Manduca sexta midgut

1993 • 46 citations

Molecular cloning of gltS and gltP, which encode glutamate carriers of Escherichia coli B

1989 • 46 citations

Hexose/H+ Symporters in Lower and Higher Plants

1994 • 40 citations

The lac permease of Escherichia coli: site-directed mutagenesis studies on the mechanism of β-galactoside/H+ symport

1990 • 40 citations

Characterization of the rat neutral and basic amino acid transporter utilizing anti-peptide antibodies.

1993 • 38 citations

Evidence that facilitative glucose transporters may fold as beta-barrels.

1993 • 35 citations

Topographical analysis of the plasma membrane-associated sucrose binding protein from soybean.

1994 • 28 citations

Urea gradient-associated fluid absorption with sigma urea = 1 in rat terminal collecting duct

1990 • 27 citations

cDNA sequence for rkST1, a novel member of the sodium ion-dependent glucose cotransporter family

1994 • 26 citations

Crystallization of porin using short chain phospholipids

1989 • 24 citations

Energy transduction and transport processes in thermophilic bacteria

1992 • 20 citations

The melibiose carrier of Escherichia coli

1990 • 17 citations

The melibiose permease of Escherichia coli: importance of the NH2-terminal domains for cation recognition by the Na+/sugar cotransporter.

1993 • 10 citations

The evolution of membrane carriers.

1993 • 7 citations

Regulation of the cystic fibrosis transmembrane conductance regulator chloride channel by MgATP.

1993 • 3 citations

Bacterial periplasmic permeases as model systems for multidrug resistance (MDR) and the cystic fibrosis transmembrane conductance regulator (CFTR).

1993 • 2 citations