Optimal absorptive transport of the dipeptide glycylsarcosine is dependent on functional Na + /H + exchange activity

Studies of Intestinal Digestion and Absorption in the Human1

1957 • 1,034 citations

Expression cloning of a mammalian proton-coupled oligopeptide transporter

1994 • 880 citations

Sodium/proton antiport in brush-border-membrane vesicles isolated from rat small intestine and kidney

1976 • 665 citations

Human Intestinal H+/Peptide Cotransporter

1995 • 495 citations

On the mechanism of intestinal absorption of drugs.

1959 • 447 citations

The Expanding Family of Eucaryotic Na+/H+Exchangers

2000 • 370 citations

NHE2 and NHE3 are human and rabbit intestinal brush-border proteins

1996 • 274 citations

Heterologous expression and functional properties of amiloride high affinity (NHE-1) and low affinity (NHE-3) isoforms of the rat Na/H exchanger

1993 • 267 citations

The effect of capping and polyadenylation on the stability, movement and translation of synthetic messenger RNAs inXenopusoocytes

1985 • 231 citations

Is intestinal peptide transport energized by a proton gradient?

1985 • 191 citations

Expression cloning of a cDNA from rabbit small intestine related to proton-coupled transport of peptides, ßlactam antibiotics and ACE-inhibitors

1994 • 189 citations

Colonic epithelial hPepT1 expression occurs in inflammatory bowel disease: Transport of bacterial peptides influences expression of MHC class 1 molecules

2001 • 188 citations

Mechanisms of the Human Intestinal H+-coupled Oligopeptide Transporter hPEPT1

1996 • 160 citations

Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3

1995 • 153 citations

Substrate upregulation of the human small intestinal peptide transporter, hPepT1

1998 • 148 citations

Direct measurement by pH-microelectrode of the pH microclimate in rat proximal jejunum

1975 • 147 citations

Transepithelial glycylsarcosine transport in intestinal Caco-2 cells mediated by expression of H(+)-coupled carriers at both apical and basal membranes.

1993 • 136 citations

Characteristics of glycylsarcosine transport in rabbit intestinal brush-border membrane vesicles.

1984 • 136 citations

H+/dipeptide absorption across the human intestinal epithelium is controlled indirectly via a functional Na+/H+ exchanger

2002 • 113 citations

Evidence for Active Transport of the Dipeptide Glycylsarcosine by Hamster Jejunum in Vitro

1972 • 96 citations

The peptide transporter PepT2 is expressed in rat brain and mediates the accumulation of the fluorescent dipeptide derivative ?-Ala-Lys-N?-AMCA in astrocytes

1999 • 92 citations

H+/solute-induced intracellular acidification leads to selective activation of apical Na+/H+ exchange in human intestinal epithelial cells

1999 • 85 citations

H+-coupled dipeptide (glycylsarcosine) transport across apical and basal borders of human intestinal Caco-2 cell monolayers display distinctive characteristics

1993 • 79 citations

Symmetry of H+ Binding to the Intra- and Extracellular Side of the H+-coupled Oligopeptide Cotransporter PepT1

1997 • 70 citations

Evidence for Active Transport of the Dipeptide Carnosine (β-Alanyl-l-Histidine) by Hamster Jejunum in Vitro

1974 • 70 citations

The effect of Escherichia coli STa enterotoxin and other secretagogues on mucosal surface pH of rat small intestine in vivo

1988 • 69 citations

Selective inhibition of the Na + /H + exchanger type 3 activates CO 2 /H + -sensitive medullary neurones

1999 • 69 citations

Localization of acid microclimate along intestinal villi of rat jejunum

1985 • 60 citations

Expression of Na+-independent amino acid transport in Xenopus laevis oocytes by injection of rabbit kidney cortex mRNA

1992 • 52 citations

The influence of buffer pH, glucose and sodium ion concentration on the acid microclimate in rat proximal jejunum in vitro

1980 • 48 citations

Direct Assessment of Dipeptide/H+ Symport in Intact Human Intestinal (Caco-2) Epithelium: A Novel Method Utilizing Continuous Intracellular pH Measurement

1993 • 47 citations

Demonstration and modification of intervillous pH profiles in rat small intestine in vitro

1989 • 39 citations

Interaction of glycylglycine and Na+ at the mucosal border of Guinea-pig small intestine

1983 • 31 citations

Differences in Characteristics between Glycine and Glycylglycine Transport in Guinea Pig Small Intestine

1978 • 24 citations

The effect of heat-stable escherichia coli enterotoxin, theophylline and forskolin on cyclic nucleotide levels and mucosal surface (acid microclimate) pH in rat proximal jejunum in vivo

1988 • 14 citations