PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback

1989 • 2,555 citations

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

2004 • 1,631 citations

Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling

2001 • 1,012 citations

The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins

2004 • 940 citations

Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4

1999 • 838 citations

A Nutrient Sensor Mechanism Controls Drosophila Growth

2003 • 769 citations

Drosophila's Insulin/PI3-Kinase Pathway Coordinates Cellular Metabolism with Nutritional Conditions

2002 • 671 citations

Rheb promotes cell growth as a component of the insulin/TOR signalling network

2003 • 648 citations

Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics

2000 • 632 citations

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

2000 • 615 citations

Control of cell number byDrosophilaFOXO: downstream and feedback regulation of the insulin receptor pathway

2003 • 596 citations

TOR signalling in bugs, brain and brawn

2003 • 568 citations

The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling

2003 • 562 citations

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

2003 • 510 citations

The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

1996 • 492 citations

Human Muscle Protein Synthesis is Modulated by Extracellular, Not Intramuscular Amino Acid Availability: A Dose‐Response Study

2003 • 489 citations

Environmental control of the cell cycle in Drosophila: nutrition activates mitotic and endoreplicative cells by distinct mechanisms

1998 • 456 citations

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

2001 • 449 citations

Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

2000 • 431 citations

Restraining PI3K: mTOR signalling goes back to the membrane

2004 • 360 citations

Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

1999 • 349 citations

Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability

2003 • 299 citations

Genetic control of cell size

2000 • 243 citations

The Gene Search System: A Method for Efficient Detection and Rapid Molecular Identification of Genes in Drosophila melanogaster

1999 • 233 citations

Tor Kinases Are in Distinct Membrane-associated Protein Complexes inSaccharomyces cerevisiae

2003 • 233 citations

Identification and characterization of a lysosomal transporter for small neutral amino acids

2001 • 229 citations

Tuberous sclerosis complex tumor suppressor–mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

2002 • 207 citations

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1

2002 • 187 citations

Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

2002 • 180 citations

The Rheb family of GTP-binding proteins

2004 • 179 citations

Functional Characterization of Two Novel Mammalian Electrogenic Proton-dependent Amino Acid Cotransporters

2002 • 164 citations

Structure, function and immunolocalization of a proton‐coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco‐2

2003 • 154 citations

DrosophilaRheb GTPase is required for cell cycle progression and cell growth

2003 • 148 citations

A P element containing suppressor of hairy-wing binding regions has novel properties for mutagenesis in Drosophila melanogaster.

1995 • 145 citations

LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway

2003 • 140 citations

Genetic analysis of protein kinase B (AKT) in Drosophila

1998 • 138 citations

The functions of insulin signaling: size isn't everything, even in Drosophila

2003 • 130 citations

The Saccharomyces cerevisiae Rheb G-protein Is Involved in Regulating Canavanine Resistance and Arginine Uptake

2000 • 130 citations

Intracellular Sensing of Amino Acids in Xenopus laevis Oocytes Stimulates p70 S6 Kinase in a Target of Rapamycin-dependent Manner

2002 • 124 citations

Tsc1+ and tsc2+ Regulate Arginine Uptake and Metabolism in Schizosaccharomyces pombe

2004 • 109 citations

Inhibition of cellular growth and proliferation by dTOR overexpression in Drosophila

2002 • 94 citations

PTEN: tumour suppressor, multifunctional growth regulator and more

2003 • 90 citations

minidiscs encodes a putative amino acid transporter subunit required non-autonomously for imaginal cell proliferation

2000 • 73 citations

The Proton/Amino Acid Cotransporter PAT2 Is Expressed in Neurons with a Different Subcellular Localization than Its Paralog PAT1

2004 • 52 citations

4‐Aminomethylbenzoic acid is a non‐translocated competitive inhibitor of the epithelial peptide transporter PepT1

1998 • 50 citations

A novel bifunctionality: PAT1 and PAT2 mediate electrogenic proton/amino acid and electroneutral proton/fatty acid symport

2004 • 45 citations

Structure, tissue expression pattern, and function of the amino acid transporter rat PAT2

2003 • 41 citations

Amino acid control of proteolysis in perfused livers of synchronously fed rats. Mechanism and specificity of alanine co-regulation.

1991 • 39 citations

Osmoregulation in Drosophila melanogaster selected for urea tolerance

1999 • 33 citations

Organization and expression of the SLC36 cluster of amino acid transporter genes

2004 • 30 citations

Deleted Work

1955 • 0 citations