Dominant transplantation tolerance

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

Toll Pathway-Dependent Blockade of CD4 ⁺ CD25 ⁺ T Cell-Mediated Suppression by Dendritic Cells

2003 • 2,023 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Donor-type CD4+CD25+ Regulatory T Cells Suppress Lethal Acute Graft-Versus-Host Disease after Allogeneic Bone Marrow Transplantation

2002 • 1,117 citations

The infusion of ex vivo activated and expanded CD4+CD25+ immune regulatory cells inhibits graft-versus-host disease lethality

2002 • 1,061 citations

Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

2002 • 1,035 citations

Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide

2003 • 976 citations

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

1996 • 909 citations

"Infectious" Transplantation Tolerance

1993 • 890 citations

Type 1 T regulatory cells

2001 • 829 citations

IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo

2001 • 799 citations

Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells.

1996 • 788 citations

CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses

2002 • 766 citations

Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

1999 • 762 citations

CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms

2003 • 748 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 709 citations

Generation of Human CD8 T Regulatory Cells by CD40 Ligand–activated Plasmacytoid Dendritic Cells

2002 • 659 citations

Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo

2001 • 658 citations

SOCS-1 Participates in Negative Regulation of LPS Responses

2002 • 636 citations

Regulatory T Cells Induced by 1α,25-Dihydroxyvitamin D3 and Mycophenolate Mofetil Treatment Mediate Transplantation Tolerance

2001 • 627 citations

Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance

1999 • 621 citations

SOCS1/JAB Is a Negative Regulator of LPS-Induced Macrophage Activation

2002 • 618 citations

CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness

2002 • 614 citations

Infectious Tolerance

2002 • 614 citations

Identification of Regulatory T Cells in Tolerated Allografts

2002 • 577 citations

CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-10

2001 • 564 citations

Local synthesis of complement component C3 regulates acute renal transplant rejection

2002 • 503 citations

Human CD4+CD25+ Regulatory, Contact-dependent T Cells Induce Interleukin 10–producing, Contact-independent Type 1-like Regulatory T Cells

2002 • 484 citations

Dendritic cells as a tool to induce anergic and regulatory T cells

2001 • 478 citations

Homeostasis of Peripheral CD4+ T Cells: IL-2Rα and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers

2002 • 477 citations

Expression of the integrin α_Eβ₇identifies unique subsets of CD25⁺as well as CD25⁻regulatory T cells

2002 • 476 citations

Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression

2000 • 448 citations

Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells

2002 • 440 citations

OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset.

1990 • 399 citations

The Subpopulation of CD4+CD25+ Splenocytes That Delays Adoptive Transfer of Diabetes Expresses L-Selectin and High Levels of CCR7

2002 • 383 citations

Both CD4+CD25+ and CD4+CD25− Regulatory Cells Mediate Dominant Transplantation Tolerance

2002 • 372 citations

Cells Expressing Indoleamine 2,3-Dioxygenase Inhibit T Cell Responses

2002 • 344 citations

Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune Disease

2002 • 332 citations

CD3-specific antibody-induced active tolerance: from bench to bedside

2003 • 305 citations

Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action.

1990 • 302 citations

Induction of tolerance in peripheral T cells with monoclonal antibodies

1990 • 285 citations

T Cell Regulation as a Side Effect of Homeostasis and Competition

2003 • 263 citations

CD40 Ligand Blockade Induces CD4+ T Cell Tolerance and Linked Suppression

1999 • 251 citations

T cell suppression in transplantation tolerance through linked recognition.

1996 • 246 citations

Regulating the Immune Response to Transplants

2001 • 242 citations

CD25+CD4+ T cells contribute to the control of memory CD8+ T cells

2002 • 241 citations

The complementary roles of deletion and regulation in transplantation tolerance

2003 • 238 citations

HOW DO MONOCLONAL ANTIBODIES INDUCE TOLERANCE? A Role for Infectious Tolerance?

1998 • 223 citations

T Cell Death and Transplantation Tolerance

2001 • 218 citations

Cutting Edge: Anti-CD154 Therapeutic Antibodies Induce Infectious Transplantation Tolerance

2000 • 202 citations

Specific Suppression of Human CD4+ Th Cell Responses to Pig MHC Antigens by CD8+CD28− Regulatory T Cells

1998 • 188 citations

Tracking the Immunoregulatory Mechanisms Active During Allograft Tolerance

2002 • 180 citations

Regulatory T Cells Overexpress a Subset of Th2 Gene Transcripts

2002 • 180 citations

Cutting Edge: CD4+CD25+ Alloantigen-Specific Immunoregulatory Cells That Can Prevent CD8+ T Cell-Mediated Graft Rejection: Implications for Anti-CD154 Immunotherapy

2002 • 177 citations

Linked suppression of skin graft rejection can operate through indirect recognition.

1998 • 175 citations

Mechanisms in CD4 antibody‐mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells

1994 • 167 citations

AMPLIFICATION OF NATURAL REGULATORY IMMUNE MECHANISMS FOR TRANSPLANTATION TOLERANCE1

1996 • 161 citations

Dominant transplantation tolerance impairs CD8+ T cell function but not expansion

2002 • 161 citations

Chemokines: directing leukocyte infiltration into allografts

2002 • 150 citations

Rejection of H-Y Disparate Skin Grafts by Monospecific CD4+ Th1 and Th2 Cells: No Requirement for CD8+ T Cells or B Cells

1998 • 146 citations

T cell regulation in adult transplantation tolerance.

1996 • 144 citations

Cutting Edge: Linked Suppression of Skin Graft Rejection Can Operate Through Indirect Recognition

1998 • 138 citations

Tolerance in the mouse to major histocompatibility complex‐mismatched heart allografts, and to rat heart xenografts, using monoclonal antibodies to CD4 and CD8

1992 • 128 citations

The role of CD4⁺ T‐cell subsets in determining transplantation rejection or tolerance

2001 • 120 citations

Type 2 helper T cell-type cytokines and the development of "infectious" tolerance in rat cardiac allograft recipients.

1997 • 119 citations

Critical roles for IL-4, IL-5, and eosinophils in chronic skin allograft rejection

1999 • 115 citations

Fingerprints of anergic T cells

2001 • 104 citations

Dendritic cells and prospects for transplantation tolerance

2000 • 98 citations

TOLERANCE AND SUPPRESSION IN A PRIMED IMMUNE SYSTEM1

1996 • 87 citations

Heme oxygenase‐1, a protective gene that prevents the rejection of transplanted organs

2001 • 83 citations

PRETRANSPLANT ADMINISTRATION OF A SINGLE DONOR CLASS I MAJOR HISTOCOMPATABILITY COMPLEX MOLECULE IS SUFFICIENT FOR THE INDEFINITE SURVIVAL OF FULLY ALLOGENEIC CARDIAC ALLOGRAFTS

1997 • 82 citations

CD4+ CD45RB Low-Density Cells from Untreated Mice Prevent Acute Allograft Rejection

1999 • 75 citations

ANTI-CD4 MONOCLONAL ANTIBODY-INDUCED ALLOGRAFT TOLERANCE IN RATS DESPITE PERSISTENCE OF DONOR-REACTIVE T CELLS1

1997 • 74 citations

Anti-CD4 Monoclonal Antibody-Induced Tolerance to MHC-Incompatible Cardiac Allografts Maintained by CD4+ Suppressor T Cells That Are Not Dependent upon IL-4

1998 • 74 citations

A COMPARISON OF GENE EXPRESSION IN MURINE CARDIAC ALLOGRAFTS AND ISOGRAFTS BY MEANS DNA MICROARRAY ANALYSIS1

2001 • 63 citations

IL-5 Mediates Eosinophilic Rejection of MHC Class II-Disparate Skin Allografts in Mice

1999 • 56 citations

Analysis of the Innate and Adaptive Phases of Allograft Rejection by Cluster Analysis of Transcriptional Profiles

2002 • 56 citations

Reprogramming the immune system

2002 • 38 citations

Antibody-Induced Transplantation Tolerance: The Role of Dominant Regulation

2003 • 27 citations

DIFFERENTIAL NF-??B AND I??B GENE EXPRESSION DURING DEVELOPMENT OF CARDIAC ALLOGRAFT REJECTION VERSUS CD154 MONOCLONAL ANTIBODY-INDUCED TOLERANCE1

2001 • 23 citations

EXTRACELLULAR MATRIX PROTEINS IN ORGAN TRANSPLANTATION1

2000 • 20 citations

Bag-1 up-regulation in anti-CD4 mAb treated allo-activated T cells confers resistance to apoptosis

2002 • 20 citations

Impact of both donor and recipient strains on cardiac allograft survival after blockade of the CD40-CD154 costimulatory pathway1

2002 • 18 citations

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